Scalable nano-bioprobes with sub-cellular resolution for cell detection

Kanwal, Alokik; Lakshmanan, Shanmugamurthy; Bendiganavale, Ashwini; Bot, Corina; Patlolla, Anitha; Raj, Rahul; Prodan, Camelia; Iqbal, Zafar; Thomas, G. A.; Farrow, R. C.

doi:10.1016/j.bios.2013.01.066

Cited by 4 publications

(7 citation statements)

References 49 publications

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“…no SWCNTs) (see Figure 9a). The SWCNTs deposited in the windows are visible at higher magnification as shown in Figure 9b and in previously reported higher magnification SEM images where the short SWCNTs appear to be deposited in the windows and oriented vertically [3,6]. A reasonable hypothesis is that, if the length of the SWCNT is small enough, there is a high probability that the SWCNT that is closest to the window when the electric field is turned on will drift into the window and deposit on the metal.…”

Section: Electrophoretic Depositionsupporting

confidence: 65%

“…There are many applications where a vertical aligned carbon nanotube (CNT) or an array could be employed in an electronic device as the sensing or active device element. Examples include vertical transistors [1,2], biosensors [3][4][5], energy devices [6], and possible combinations of the three. In any of the aforementioned applications, the location and number of CNTs must be controlled with respect to the electrical interconnects.…”

Section: Introductionmentioning

confidence: 99%

“…short). Both versions of SWCNTs have been used in a device that performs localized impedance spectroscopy on mobile cells and may lead to a label-free cell detection method [3,4]. The EPD of the short version of the SWCNTs was also used in a nanofabricated discrete enzymatic biofuel cell device that has superior power density performance [6].…”

Section: Introductionmentioning

confidence: 99%

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Improved Electrophoretic Deposition of Vertical Single Wall Carbon Nanotubes with Nanoscopic Electrostatic Lenses

et al. 2020

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Under certain conditions, electrophoretic deposition (EPD) of single-wall carbon nanotubes (SWCNTs) onto metal at the base of nanoscale insulating windows can result in a single SWCNT per window, bonded at one end to the metal. During EPD charge, buildup on the insulator creates electrostatic lenses at the windows that control the trajectory of the SWCNTs. The aim is to develop a reproducible process for deposition of individual vertically oriented SWCNTs into each window to enable novel devices. The length of the SWCNTs is shown to be the most critical parameter in achieving results that could be used for devices. In particular, single nanotube deposition in windows by EPD was achieved with SWCNTs with lengths on the order of the window depth. By performing current vs voltage (IV) measurements against a platinum wire in a phosphate buffer and by modeling the data, the presence of the nanotube can be detected, the contact interface can be studied, and the nanotube’s viability for device applications can be determined. These results provide a basis for process integration of vertical SWCNTs using EPD.

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Section: Electrophoretic Depositionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Improved Electrophoretic Deposition of Vertical Single Wall Carbon Nanotubes with Nanoscopic Electrostatic Lenses

et al. 2020

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“…Although some reports exist, where standard EIS electrodes (such as glassy carbon) have been modified with graphene flakes, the actual role of graphene is not apparent in these measurements. In some cases, the impedance spectra of the solution have also been directly measured to detect the presence or absence of cells, for example with the help of vertically grown CNTs . Direct detection of biomolecules is also possible using electrochemical methods .…”

Section: Fundamentals Of Label‐free Electrical Detectionmentioning

confidence: 99%

25th Anniversary Article: Label‐Free Electrical Biodetection Using Carbon Nanostructures

Balasubramanian

Kern

2014

Advanced Materials

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Nanostructures are promising candidates for use as active materials for the detection of chemical and biological species, mainly due to the high surface-to-volume ratio and the unique physical properties arising at the nanoscale. Among the various nanostructures, materials comprised of sp(2) -carbon enjoy a unique position due to the possibility to readily prepare them in various dimensions ranging from 0D, through 1D to 2D. This review focuses on the use of 1D (carbon nanotubes) and 2D (graphene) carbon nanostructures for the detection of biologically relevant molecules. A key advantage is the possibility to perform the sensing operation without the use of any labels or complex reaction schemes. Along this spirit, various strategies reported for the label-free electrical detection of biomolecules using carbon nanostructures are discussed. With their promise for ultimate sensitivity and the capability to attain high selectivity through controlled chemical functionalization, carbon-based nanobiosensors are expected to open avenues to novel diagnostic tools as well as to obtain new fundamental insight into biomolecular interactions down to the single molecule level.

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“…Many kinds of methods, such as electrochemical impedance spectroscopy (Cao et al, 2012;Faenza et al, 2012;Giaever and Keese, 1993), scanning electrochemical microscopy (Allen et al, 2006;Kaya et al, 2003;Torisawa et al, 2003), electric cell-substrate impedance sensing (Arndt et al, 2004;Xiao et al, 2002;Xiao and Luong, 2003), open circuit potential at the cell/sensor interface (Woolley et al, 2002), and electron transfer at electroactive centers in cells (El-Said et al, 2009;Li et al, 1999;Wu et al, 2009), have been approved to be effective to provide nonmorphological observation for following cell health state and establishing effective in vitro anticancer drug sensitivity tests (Kanwal et al, 2013;Wu D.M. et al, 2011;Zhang D.D.…”

Section: Introductionmentioning

confidence: 99%

A new disposable electrode for electrochemical study of leukemia K562 cells and anticancer drug sensitivity test

Zhu

Wang

et al. 2014

Biosensors and Bioelectronics

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Scalable nano-bioprobes with sub-cellular resolution for cell detection

Cited by 4 publications

References 49 publications

Improved Electrophoretic Deposition of Vertical Single Wall Carbon Nanotubes with Nanoscopic Electrostatic Lenses

Improved Electrophoretic Deposition of Vertical Single Wall Carbon Nanotubes with Nanoscopic Electrostatic Lenses

25th Anniversary Article: Label‐Free Electrical Biodetection Using Carbon Nanostructures

A new disposable electrode for electrochemical study of leukemia K562 cells and anticancer drug sensitivity test

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