Micropile groups have been progressively more frequently adopted in the construction of transmission tower bases due to their compact size and flexible construction advantages. However, the load-bearing characteristics and deformation mechanisms of micropile groups are complex, and the study of their coupling effects under combined loads remains unclear. Consequently, this paper presents a field static load test of micropile groups in a highland mountainous area. The analysis encompasses the axial force distribution and load-sharing ratio of micropiles. With a focus on micropile groups subjected to both uplift and horizontal combined loads, the coupled effects under different load combination ratios are examined using numerical simulation methods. The key findings are as follows: During the uplift loading process, the load distribution among individual piles is relatively uniform, with lower side friction resistance gradually coming into play to counterbalance the top load. The load–uplift displacement curve exhibits a steep characteristic, making it susceptible to sudden failure in practical engineering applications. Under the simultaneous action of uplift (V) and horizontal (H) loads, the unbalanced lateral frictional resistance on both sides of the pile segment induces additional bending moments, which is an important part affecting the load-coupling mechanisms. The uplift resistance capacity of micropile groups decreases with an increase in horizontal load, while the horizontal load-carrying capacity initially decreases and then increases with an increase in uplift load. The space enclosed by the yield envelope under combined load, and the vertical line of the ultimate load, is divided into a ‘failure zone’ and a ‘safety zone.’ In the design of the pile foundation, the uplift bearing capacity reduced by the ‘failure zone’ should be taken into account.