2014
DOI: 10.1038/nn.3701
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Scaling down of balanced excitation and inhibition by active behavioral states in auditory cortex

Abstract: Cortical sensory processing is modulated by behavioral and cognitive states. How the modulation is achieved through impacting synaptic circuits remains largely unknown. In awake mouse auditory cortex, we reported that sensory-evoked spike responses of layer 2/3 (L2/3) excitatory cells were scaled down with preserved sensory tuning when animals transitioned from quiescence to active behaviors, while L4 and thalamic responses were unchanged. Whole-cell voltage-clamp recordings further revealed that tone-evoked s… Show more

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Cited by 317 publications
(437 citation statements)
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References 56 publications
(95 reference statements)
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“…We therefore defined epochs where movement speed was above and below 1.5 cm/s as representing active and quiescent periods, respectively. Consistent with previous reports (Schneider et al, 2014;Zhou et al, 2014), we found that responses to random sounds were smaller during active periods ( Fig. 9B,C; LFP peak amplitude; n ϭ 80 sites, p Ͻ 0.0001).…”
Section: Attenuation Of Self-generated Sounds Is Not Caused Simply Bysupporting
confidence: 93%
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“…We therefore defined epochs where movement speed was above and below 1.5 cm/s as representing active and quiescent periods, respectively. Consistent with previous reports (Schneider et al, 2014;Zhou et al, 2014), we found that responses to random sounds were smaller during active periods ( Fig. 9B,C; LFP peak amplitude; n ϭ 80 sites, p Ͻ 0.0001).…”
Section: Attenuation Of Self-generated Sounds Is Not Caused Simply Bysupporting
confidence: 93%
“…Previous studies have shown that evoked responses in the auditory thalamus are reduced during active behavior (McGinley et al, 2015b;Williamson et al, 2015; but see Otazu et al, 2009;Zhou et al, 2014). We observed in our study that auditory thalamic neurons showed mild attenuation of responses to selfgenerated sounds.…”
Section: Discussionsupporting
confidence: 62%
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“…Recent findings pointed out that motor activity influences auditory processes in the primary auditory cortex (Remington et al 2012;Schneider and Mooney 2015;Xiong et al 2015;Zhou et al 2014). Thus, the auditory cortex may be part of a sensorimotor system that links auditory stimuli to specific motor responses and, therefore, the differences detected in the present study between fear vs. appetitive paradigms may be due to such the different motor responses paired to tones.…”
Section: Te2 Activity After the Recall Of An Auditory Signaled Two-wamentioning
confidence: 99%