Scanned focussed ultrasound hyperthermia: Clinical response evaluation

Intense Focused Ultrasound: Evaluation of a New Treatment Modality for Precise Microcoagulation within the Skin

“…High-intensity focused ultrasound (HIFU) has been investigated as a tool for the treatment of solid benign and malignant tumors for many decades, but is only now beginning to emerge as a potential noninvasive alternative to conventional therapies. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] The histologic morphology of tissue destruction induced by focused ultrasound (US) shows coagulative ne-crosis with precisely defined, sharp margins to normal tissue. 21 The primary physical mechanism responsible for tissue necrosis with focused US treatment is heating due to absorption of acoustic energy, although some concomitant inertial cavitational response of tissue from an intense US field is probably also present.…”

Conductive interstitial thermal therapy device for surgical margin ablation:In vivoverification of a theoretical model

“…Thermal ablation techniques, such as radiofrequency ablation [15][16][17][18][19][20][21][22], laser ablation [10][11][12][13][14][23][24][25][26], cryotherapy [27,28], and focused ultrasound with MRI guidance [1,[29][30][31][32][33][34], have shown promising results by destroying cancer cells via thermal energy delivery to target tissue. A common denominator among all these techniques, excluding cryotherapy, is that electromagnetic or acoustic energy is selectively absorbed by various tissue components and is converted to heat.…”

Minimally Invasive Approaches for Diagnosis and Treatment of Early-Stage Breast Cancer

“…The only reported adverse effects were pain and minimal skin bruising [34]. For breast cancer, several groups investigated FUS in pilot studies including patients with inoperable tumors, but the results were not verified on surgical specimens [35,36].…”