Scanning Electron Microscopy of the Cochlea in Rats With Streptococcus pneumoniae Otitis Media

Kb, Hodges; Je, Penny; Rd, Brown; Cm, Henley

doi:10.1001/archotol.1984.00800330011002

Cited by 15 publications

(6 citation statements)

References 5 publications

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“…Outer hair cell loss in the cochlear base and other pathological inner ear changes have been reported in experimental OM [44,45]. The effects of inoculating S. pneumoniae into the middle ear suggest that bacterial OM can produce cytotoxic changes in outer and inner ear hair cells in the cochlea [1,46]. These changes may be significant factors in the temporary or permanent SNHL that has been associated with bacterial OM [47].…”

Section: Inner Ear Changes In Otitis Mediamentioning

confidence: 99%

Round window membrane and labyrinthine pathological changes: an overview

Cüreoğlu

Schachern

Rinaldo

et al. 2005

Acta Oto-Laryngologica

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The round window membrane is considered the most likely pathway from the middle to the inner ear. Various substances placed in the middle ear have been seen to pass through the round window membrane. Once toxic substances or inflammatory mediators such as cytokines and nitric oxide enter the inner ear, various inner ear sequelae such as labyrinthitis, endolymphatic hydrops, sensorineural hearing loss or more insidious diseases can occur.

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Section: Inner Ear Changes In Otitis Mediamentioning

confidence: 99%

Round window membrane and labyrinthine pathological changes: an overview

Cüreoğlu

Schachern

Rinaldo

et al. 2005

Acta Oto-Laryngologica

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“…Previous animal studies have shown destruction of cochlear OHCs in acute OM. 23 Damage to the OHCs is believed to result from the passage of inflammatory mediators from the middle to inner ear via a permeable round window membrane. 24 Histomorphologic study of representative cochlea from each of our study groups demonstrated disorganization and loss of cochlear outer hair cells (OHCs) in the untreated PA OM ears that underwent stapedotomy.…”

Section: Discussionmentioning

confidence: 99%

Hearing Loss with Stapedotomy and Treated Otitis Media

Zhang

Young

et al. 2006

Otolaryngol.--head neck surg.

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“…LeVine et al (2000) demonstrated that SP-D and SP-A play roles in modulating cytokine production and inflammatory responses during bacterial pneumonia (Streptococcus pneumonia). Streptococcal pneumonia is one of the causative agents of middle ear inflammation and causes changes occuring in a defined sequence; i.e., damage to the supporting cells, changes in stereocilia, and, finally, hair cell loss (Hodges et al, 1984). These findings suggest that surfactant proteins may be important in combating infections at sites other than the lung.…”

Section: Discussionmentioning

confidence: 99%

Immunodetection of surfactant proteins in human organ of Corti, Eustachian tube and kidney.

Kankavi

2003

Acta Biochim Pol

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The presence of surfactant proteins was investigated in the human organ of Corti, Eustachian tube and kidney tissues. It has previously been shown that lamellar bodies are present in hairy cells of organ of Corti, in the cytoplasm of secretory and lumen of tubal glands of Eustachian tube and kidney renal basement membrane. No evidence for the presence of surfactant proteins in the organ of Corti and kidney has been presented until now. The aim of this study was to find out if surfactant proteins were expressed in other epithelia such as organ of Corti, Eustachian tube and kidney. Surfactant proteins were identified using one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting. On one-dimensional Western blots, bands for surfactant protein A in human Eustachian tube (SP-A, 34 kDa) and in kidney extracts, and for surfactant protein D (SP-D, 43 kDa) in Eustachian tube and in kidney extracts (SP-D, 86 kDa), and for surfactant protein B (SP-B, 8 kDa) in human Eustachian tube and organ of Corti extracts were detected. Bands corresponded to monomeric forms of lung surfactant proteins. These results indicate the presence of SP-A and SP-D in kidney epithelium, SP-A, SP-B and SP-D in Eustachian tube and SP-B in the organ of Corti.

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Scanning Electron Microscopy of the Cochlea in Rats With Streptococcus pneumoniae Otitis Media

Cited by 15 publications

References 5 publications

Round window membrane and labyrinthine pathological changes: an overview

Round window membrane and labyrinthine pathological changes: an overview

Hearing Loss with Stapedotomy and Treated Otitis Media

Immunodetection of surfactant proteins in human organ of Corti, Eustachian tube and kidney.

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