Scanning, non-contact, hybrid broadband diffuse optical spectroscopy and diffuse correlation spectroscopy system

Johansson, Johannes; Mireles, Miguel; Morales-Dalmau, Jordi; Martínez-Lozano, Mar; Casanovas, Oriol; Durdurán, Turgut

doi:10.1364/boe.7.000481

Cited by 14 publications

(22 citation statements)

References 83 publications

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“…He et al used a motorized stage to move the source and detectors over the scan region and used this system to capture the blood flow contrast in patients with breast tumors [46]. Johansson et al constructed a scanning system that used a motorized stage to move the subject rather than the source-detector pattern and combined diffuse correlation measurements with broadband diffuse optical measurements to study the hemodynamics of mouse tumor [69]. However, in general, DCT is still a technology that has not been widely applied.…”

Section: Development Of Methodsmentioning

confidence: 99%

Non-invasive diffuse correlation tomography reveals spatial and temporal blood flow differences in murine bone grafting approaches

Han

Proctor

Vella³

et al. 2016

Biomed. Opt. Express

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Longitudinal blood flow during murine bone graft healing was monitored non-invasively using diffuse correlation tomography. The system utilized spatially dense data from a scanning set-up, non-linear reconstruction, and micro-CT anatomical information. Weekly measurements were performed. Blood flow changes in autografts, which heal successfully, were localized to graft regions and consistent across mice. Poor healing allografts showed heterogeneous blood flow elevation and high inter-subject variabilities. Allografts with tissue-engineered periosteum showed responses intermediate to both autografts and allografts, consistent with healing observed. These findings suggest that spatiotemporal blood flow changes can be utilized to differentiate the degree of bone graft healing.

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Section: Development Of Methodsmentioning

confidence: 99%

Non-invasive diffuse correlation tomography reveals spatial and temporal blood flow differences in murine bone grafting approaches

Han

Proctor

Vella³

et al. 2016

Biomed. Opt. Express

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“…This may introduce an artificial variability in the estimated hemodynamic parameters. To overcome this challenge and to increase the spatial/temporal resolution, we can deploy non-contact optical elements to scan the tumor surface [93].…”

Section: Discussionmentioning

confidence: 99%

Pre-clinical longitudinal monitoring of hemodynamic response to anti-vascular chemotherapy by hybrid diffuse optics

Johansson

Mireles

Jiménez-Valerio

et al. 2017

Biomed. Opt. Express

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Abstract:The longitudinal effect of an anti-vascular endothelial growth factor receptor 2 (VEGFR-2) antibody (DC 101) therapy on a xenografted renal cell carcinoma (RCC) mouse model was monitored using hybrid diffuse optics. Two groups of immunosuppressed male nude mice (seven treated, seven controls) were measured. Tumor microvascular blood flow, total hemoglobin concentration and blood oxygenation were investigated as potential biomarkers for the monitoring of the effect of therapy twice a week and were related to the final treatment outcome. These hemodynamic biomarkers have shown a clear differentiation between two groups by day four. Moreover, we have observed that pre-treatment values and early changes in hemodynamics are highly correlated with the therapeutic outcome demonstrating the potential of diffuse optics to predict the therapy response at an early time point. References and links1. J. Folkman, "What is the evidence that tumors are angiogenesis dependent?" J. Natl. Cancer Inst. 82(1), 4-6 (1990). 2. J. Folkman, "Angiogenesis in cancer, vascular, rheumatoid and other disease," Nat. Med. 1(1), 27-30 (1995). 3. P. Carmeliet and R. K. Jain, "Angiogenesis in cancer and other diseases," Nature 407(6801), 249-257 (2000). 4. N. Ferrara, H.-P. Gerber, and J. LeCouter, "The biology of VEGF and its receptors," Nat. Med. 9(6), 669-676 (2003). 5. J. Folkman, "Angiogenesis: an organizing principle for drug discovery?" Nat. Rev. Drug Discov. 6(4), 273-286 (2007). 6. L. M. Ellis and D. J. Hicklin, "VEGF-targeted therapy: mechanisms of anti-tumour activity," Nat. Rev. Cancer 8(8), 579-591 (2008

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“…The normalized electric field autocorrelation for a semi‐infinite geometry, g 1 (dimensionless unit, denoted by [–] in this study), was used to fit a Brownian diffusion coefficient D b (cm 2 /s) to the measurements according to :

g_{1} = \frac{(\frac{e^{- K ((), τ) r_{1}}}{r_{1}} - \frac{e^{- K ((), τ) r_{2}}}{r_{2}})}{(\frac{e^{- K ((), 0) r_{1}}}{r_{1}} - \frac{e^{- K ((), 0) r_{2}}}{r_{2}})} .

…”

Section: Methodsmentioning

confidence: 99%

“…Coherent lasers have a very narrow spectral broadening around its wavelength and the interference from such light can form clear speckle patterns on optical detectors. These speckles from light scattered in turbid media are used for monitoring relative changes in microvascular blood flow in a number of techniques such as laser Doppler flowmetry (LDF) , laser speckle contrast imaging and diffuse correlation spectroscopy (DCS) . The techniques rely on the effect that moving light‐scattering particles, such as red blood cells, will cause the speckle pattern to change over time.…”

Section: Introductionmentioning

confidence: 99%

A multipixel diffuse correlation spectroscopy system based on a single photon avalanche diode array

Johansson

Portaluppi

Buttafava

et al. 2019

Journal of Biophotonics

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The autocorrelation of laser speckles from coherent near infrared light is used for noninvasive estimates of relative changes in blood perfusion in techniques such as laser Doppler flowmetry (LDF) and diffuse correlation spectroscopy (DCS). In this study, a 2D array of single photon avalanche diodes (SPADs) was used to combine the strengths of multiple detectors in LDF with high light sensitivity in DCS. The system was tested on milk phantoms with varying detector fiber diameter (200 and 600 μm), source-detector fiber separation (4.6-10.2 mm), fiber-SPAD distance (2.5-36.5 mm), contiguous measurement time per repetition for the autocorrelation (1-33 ms) and temperature (15.6-46.7 C). An in vivo blood occlusion test was also performed. The multipixel approach improved signal-to-noise ratio (SNR) and, in our setup, the use of a multimode detector fiber was beneficial for SNR. In conclusion, the multipixel system works, but improvements and further studies regarding, for example, the data acquisition and optimal settings are still needed. K E Y W O R D Sblood flow measurements, diffuse correlation spectroscopy, laser Doppler flowmetry, SPAD array

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Scanning, non-contact, hybrid broadband diffuse optical spectroscopy and diffuse correlation spectroscopy system

Cited by 14 publications

References 83 publications

Non-invasive diffuse correlation tomography reveals spatial and temporal blood flow differences in murine bone grafting approaches

Non-invasive diffuse correlation tomography reveals spatial and temporal blood flow differences in murine bone grafting approaches

Pre-clinical longitudinal monitoring of hemodynamic response to anti-vascular chemotherapy by hybrid diffuse optics

A multipixel diffuse correlation spectroscopy system based on a single photon avalanche diode array

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