Scar Revision Review

Thomas, J. Regan; Somenek, Michael

doi:10.1001/archfaci.2012.223

Cited by 14 publications

(4 citation statements)

References 110 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Treatment for scars includes dermabrasion, micro needling, injections, pressure therapy, radiotherapy, fillers and surgical revision of scars 20,21,22,23,24 . It is prudent to reduce the occurrence of postoperative scar as effectively as possible in order to void future aesthetic, functional and financial burdens associated with scarring 25,26 .…”

Section: Discussionmentioning

confidence: 99%

Role of topical hemocoagulase in postoperative wound healing following dentoalveolar extraction

Albert

Muthusekhar

Sivashanmugam

et al. 2022

ijhs

View full text Add to dashboard Cite

Background: Wound healing consists of sequential overlapping events, namely, hemostasis, inflammation, proliferation and remodelling. Disruption of one or more of these events results in impaired healing of the wound which causes functional, esthetic and emotional burdens in the future. Hemocoagulase is an enzyme derived from snake venom which is widely used for its hemostatic properties. In recent times, it has shown to enhance wound healing and reduce scar formations. The objective of this systematic review is to compare the effectiveness of topical hemocoagulase and placebo/control in postoperative wound healing following dentoalveolar extraction. Methodology: A systematic review was carried out to explore the use of hemocoagulase in wound healing of dental extraction sockets. The Databases of PubMed, Cochrane and Google scholar were searched for the related topics along with a complimentary manual search of all oral surgery journals till December 2020. Results: A total of eleven studies were revealed on data search. After application of inclusion and exclusion criteria based on the filtering process, two clinical trials were included for final appraisal. Of the two clinical trials, one compared topical hemocoagulase with placebo and one clinical trial compared topical hemocoagulase with control. Both trials included patients undergoing bilateral dental extraction.

show abstract

Section: Discussionmentioning

confidence: 99%

Role of topical hemocoagulase in postoperative wound healing following dentoalveolar extraction

Albert

Muthusekhar

Sivashanmugam

et al. 2022

ijhs

View full text Add to dashboard Cite

show abstract

“…In this regard, to ensure the best aesthetic result, the appropriate surgical technique must include delicate tissue manipulation, aseptic technique, the precision of anatomical dissection, careful hemostasis, adequate design, debridement of devitalized tissue, closure of deep layers to obliterate space, wide detachment, edge eversion, avoidance of tension and aesthetically favorable alignment [7][8][9][10].…”

Section: Letter To the Editormentioning

confidence: 99%

“…The timing of the intervention depends on the type of procedure that is planned and the presence of functional deficiencies. Review after 8 to 12 weeks in adults and 6 months in younger children may be appropriate [10].…”

Section: Best Intervention Momentmentioning

confidence: 99%

Classification of Facial Fibrosis: A Guideline

Valente¹

2022

Preprint

View full text Add to dashboard Cite

“…In superficial lesions, the damaged epidermis is able to regenerate forming a neo-tissue that is indistinguishable from the undamaged one. On the contrary, the dermis heals through a repair process that leads to the formation of the scar [ 2 , 3 , 4 ]. Although complex, the repair process is a “mere” closing of the gap with the final aim of restoring the mechanical integrity of the damaged area, preventing the loss of blood and body fluids and pathogens invasion.…”

Section: Introductionmentioning

confidence: 99%

Bioengineered Wound Healing Skin Models: The Role of Immune Response and Endogenous ECM to Fully Replicate the Dynamic of Scar Tissue Formation In Vitro

et al. 2022

View full text Add to dashboard Cite

The healing of deep skin wounds is a complex phenomenon evolving according with a fine spatiotemporal regulation of different biological events (hemostasis, inflammation, proliferation, remodeling). Due to the spontaneous evolution of damaged human dermis toward a fibrotic scar, the treatment of deep wounds still represents a clinical concern. Bioengineered full-thickness skin models may play a crucial role in this direction by providing a deep understanding of the process that leads to the formation of fibrotic scars. This will allow (i) to identify new drugs and targets/biomarkers, (ii) to test new therapeutic approaches, and (iii) to develop more accurate in silico models, with the final aim to guide the closure process toward a scar-free closure and, in a more general sense, (iv) to understand the mechanisms involved in the intrinsic and extrinsic aging of the skin. In this work, the complex dynamic of events underlaying the closure of deep skin wound is presented and the engineered models that aim at replicating such complex phenomenon are reviewed. Despite the complexity of the cellular and extracellular events occurring during the skin wound healing the gold standard assay used to replicate such a process is still represented by planar in vitro models that have been largely used to identify the key factors regulating the involved cellular processes. However, the lack of the main constituents of the extracellular matrix (ECM) makes these over-simplistic 2D models unable to predict the complexity of the closure process. Three-dimensional bioengineered models, which aim at recreating the closure dynamics of the human dermis by using exogenous biomaterials, have been developed to fill such a gap. Although interesting mechanistic effects have been figured out, the effect of the inflammatory response on the ECM remodelling is not replicated yet. We discuss how more faithful wound healing models can be obtained by creating immunocompetent 3D dermis models featuring an endogenous ECM.

show abstract

Scar Revision Review

Cited by 14 publications

References 110 publications

Role of topical hemocoagulase in postoperative wound healing following dentoalveolar extraction

Role of topical hemocoagulase in postoperative wound healing following dentoalveolar extraction

Classification of Facial Fibrosis: A Guideline

Bioengineered Wound Healing Skin Models: The Role of Immune Response and Endogenous ECM to Fully Replicate the Dynamic of Scar Tissue Formation In Vitro

Contact Info

Product

Resources

About