2016
DOI: 10.1063/1.4958594
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Scarless wound healing gel with Binahong (Anredera cordifolia (Ten) Steenis) leaves extract and celecoxib as the active ingredients

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Cited by 12 publications
(7 citation statements)
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“…Firstly, we demonstrated that COX-2 and TGF Beta-1 showed similar cellular profiles as both were expressed mainly by the infiltrating inflammatory cells in the wound area, this was in line with other studies [52][53][54][55], however, we endorsed our finding by showing for the first time actual colocalization of Cox-2 and TGF Beta-1 on the cellular level in the wound area. Secondarily, demonstrating that both mediators showed a similar pattern of expression in the wound, where COX-2 upregulation and downregulation was associated with a concomitant similar change in TGF Beta-1, this was in line with other studies in different animal models of inflammation [61][62][63][64][65][66][67][68][69][70]. Thirdly, we endorsed this COX-2 and TGF Beta-1 coordinated relation results further by a correlation studies that showed for the first time a strong correlation between COX-2 and TGF Beta-1 in dermal wounds.…”
Section: Discussionsupporting
confidence: 88%
“…Firstly, we demonstrated that COX-2 and TGF Beta-1 showed similar cellular profiles as both were expressed mainly by the infiltrating inflammatory cells in the wound area, this was in line with other studies [52][53][54][55], however, we endorsed our finding by showing for the first time actual colocalization of Cox-2 and TGF Beta-1 on the cellular level in the wound area. Secondarily, demonstrating that both mediators showed a similar pattern of expression in the wound, where COX-2 upregulation and downregulation was associated with a concomitant similar change in TGF Beta-1, this was in line with other studies in different animal models of inflammation [61][62][63][64][65][66][67][68][69][70]. Thirdly, we endorsed this COX-2 and TGF Beta-1 coordinated relation results further by a correlation studies that showed for the first time a strong correlation between COX-2 and TGF Beta-1 in dermal wounds.…”
Section: Discussionsupporting
confidence: 88%
“…Tumbuhan yang dapat ditemui di alam bebas di hutan tropis Indonesia banyak dilaporkan mengandung senyawa aktif seperti antioksidan, antitoksik, bahan penyembuh luka, dan aktivitas lainnya. 1,2 Dalam beberapa dekade ini, penelitian mengenai pengembangan proses isolasi senyawa penyembuh luka mulai marak dikembangkan. 3 Salah satu tumbuhan khas yang terdapat di hutan tropis Indonesia adalah hasil ekstraksi daun Binahong atau yang memiliki nama latin (Anredera cordifolia (Ten) Steenis).…”
Section: Pendahuluanunclassified
“…Steenis). 2,6 Kandungan kimia daun binahong pada penelitian sebelumya telah dilaporkan bahwa terdapat kandungan saponin, alkaloid, terpenoid dan flavonoid. 7 Senyawa-senyawa kimia daun binahong diduga dapat membantu proses penyembuhan luka yaitu asam askorbat, saponin alkaloid dan flavonoid.…”
Section: Pendahuluanunclassified
“…Anredera cordifolia is a well-recognized medicinal plant that belong to Basellaceae family. A. cordifolia possesses pharmacological activities such as antibacterial [16], gastroprotective [17], antivirus [18], antidiabetic [19], antiinflammatory [20], wound healing [21] and antioxidant [22]. Phytochemical screening has revealed the presence of flavanols [18], glycosides, alkaloids [23], flavonoids [24], saponin and steroid [19] in different parts.…”
Section: Introductionmentioning
confidence: 99%