Scarring impedes regeneration at sites of peripheral nerve repair

Atkins, Simon; Smith, Kelly B.; Loescher, Alison R.; Boissonade, Fiona M.; O’Kane, Sharon; Ferguson, Mark W. J.; Robinson, P.P.

doi:10.1097/01.wnr.0000230519.39456.ea

Cited by 98 publications

(72 citation statements)

References 17 publications

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“…Recent studies have supported these results by demonstrating that the gradual elongation of the nerve is beneficial to peripheral nerve regeneration 21,22 . As our results suggest that the lack of mobilization after a peripheral nerve lesion increases the amount of collagen and may prevent regeneration, graded nerve mobilization may be an important procedure to prevent those maladaptive changes 23 .…”

Section: Fibrosismentioning

confidence: 64%

Neurodynamic Mobilization Reduces Intraneural Fibrosis After Sciatic Crush Lesion in Rats

Lima

Santana

Medrado

et al. 2017

BJMHH

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| Peripheral nerve lesions may be associated with abnormal scarring that lead to regenerative failure and dysfunction. Neurodynamic mobilization (NM) imposes controlled mechanical loads on the peripheral nerve and may influence inflammation and collagen deposition after a lesion. However, there is lack of experimental data to support these claims. Objective: To evaluate the impact of NM in the intraneural number of mast cells, collagen deposition and number of blood vessels after an ischiatic crush lesion in rats. Methods: This is a laboratory animal study, where 20 rats (Rattus norvegicus) were randomly divided into two groups, NM (n=10) and control (n=10), submitted to a right ischiatic nerve lesion. A tensioning NM began 10 days after lesion, and was maintained once a day, six times a week, for three weeks. After this period, the animals were euthanized and the nerves assessed for the number of mast cells, collagen area and number of blood vessels. Results: NM led to a lower number of degranulated mast cells (Kruskal-Wallis = 0.29 p<0.05), higher organization of collagen deposition (KruskalWallis = 0.01, p<0.05 ). There was no influence of NM on the number of intraneural blood vessels (KruskalWallis = 0.46 p<0.05). Conclusion: NM started 10 days after a ischiatic nerve crush lesion modulates the inflammatory process and prevents random deposition of collagen at the lesion site, but has no influence on blood vessels formation.

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Section: Fibrosismentioning

confidence: 64%

Neurodynamic Mobilization Reduces Intraneural Fibrosis After Sciatic Crush Lesion in Rats

Lima

Santana

Medrado

et al. 2017

BJMHH

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“…As an example, injection of collagen IV antibody was shown to improve regeneration after a mechanical transsection of postcommissural fornix in the adult rat [132]. Formation of a collagenous scar also occurs in the PNS and could attenuate nerve repair [133]. Peripheral nerve injuries induce profound changes that include morphological rearrangements, apoptosis of neurons, proliferation and activation of glial cells in the sensory ganglia where the soma of sensory neurons is located.…”

Section: Collagens In Nerve Injury and Nerve Repairmentioning

confidence: 99%

Collagens in the developing and diseased nervous system

Hübert

Grimal

Carroll

et al. 2008

Cell. Mol. Life Sci.

105

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Collagens are extracellular proteins characterized by a structure in triple helices. There are 28 collagen types which differ in size, structure and function. Their architectural and functional roles in connective tissues have been widely assessed. In the nervous system, collagens are rare in the vicinity of the neuronal soma, occupying mostly a "marginal" position, such as the meninges, the basement membranes and the sensory end organs. In neural development, however, where various ECM molecules are known to be determinant, recent studies indicate that collagens are no exception, participating in axonal guidance, synaptogenesis and Schwann cell differentiation. Insights on collagens function in the brain have also been derived from neural pathophysiological conditions. This review summarizes the significant advances which underscore the function and importance of collagens in the nervous system.

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“…However, fibroblasts (FIBs) in the connective tissue surrounding the axoneSchwann cell bundles usually have stronger mobility [5]. After injury, they migrate into the wound sites in the first place and secrete collagen and transforming growth factors (TGFs) which encourage the formation of scar tissue, impeding the migration of Schwann cells and thus regeneration of functional nerve tissue [6,7]. Therefore, it is of great importance to develop a material which is able to specifically guide the directional migration of Schwann cells, whereas suppresses the migration of fibroblasts.…”

Section: Introductionmentioning

confidence: 99%