Scavenging action of propolis extract against oxygen radicals

Pascual, Carlos; González, Ricardo; Torricella, R.G.

doi:10.1016/0378-8741(94)90052-3

Cited by 144 publications

(94 citation statements)

References 13 publications

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“…19) Contrary, Basnet et al 20) demonstrated a pronounced anti-oxidative potential of an aqueous extract of Brazilian propolis. The isolated phenolic compound propol was more potent than vitamin C and E in the DPPH free radical assay system.…”

Section: Resultsmentioning

confidence: 99%

Effects of Propolis on Hypoxanthine-Xanthine Oxidase-Induced Toxicity in Cultivated Human Cells and on Neutrophil Elastase Activity

Beyer

Melzig

2005

Biological & Pharmaceutical Bulletin

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The inhibition of the proliferation rate of the immortalized human cell line ECV 304 after oxidant damage by oxygen radicals generated in a hypoxanthin-xanthine oxidase system and the protection provided by various propolis extracts was determined. Best inhibition was demonstrated by 60-80% ethanolic extracts (IC 50 of approximately 2 m mg dry weight/ml) and by the ethyl acetate extract (IC 50 of 6.9 m mg dry weight/ml). The beneficial effect of polar extracts was quite weak. Human neutrophil elastase activity was inhibited distinctively by ethanolic (60 to 96 %) and ethyl acetate extracts (IC 50 of approximately 2 m mg dry weight/ml). Both activities seem to be responsible for the anti-inflammatory effect of the extract.

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Section: Resultsmentioning

confidence: 99%

Effects of Propolis on Hypoxanthine-Xanthine Oxidase-Induced Toxicity in Cultivated Human Cells and on Neutrophil Elastase Activity

Beyer

Melzig

2005

Biological & Pharmaceutical Bulletin

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“…The intensification of the oxidative stress enhances the influence of non-essential fatty acids which, in turn, increase the serum and tissue levels of cholesterol and triglycerides. It has been shown that antioxidants and flavonoids can act as inhibitors of lipid peroxidation by neutralizing the radicals of polyunsaturated fatty acids and by interrupting the chain reactions [28]. Lipid peroxidation is an important biological consequence of cellular oxidative stress and is one of the main causes of hepatic lesions produced by CCl 4 mediated by the free radicals derived from this toxic substance [3,21,[29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Effect of Apitherapy Formulations against Carbon Tetrachloride-Induced Toxicity in Wistar Rats after Three Weeks of Treatment

Andriţoiu

Ochiuz

Andriţoiu³

et al. 2014

Molecules

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Abstract:The human body is exposed nowadays to increasing attacks by toxic compounds in polluted air, industrially processed foods, alcohol and drug consumption that increase liver toxicity, leading to more and more severe cases of hepatic disorders. The present paper aims to evaluate the influence of the apitherapy diet in Wistar rats with carbon tetrachloride-induced hepatotoxicity, by analyzing the biochemical determinations (enzymatic, lipid and protein profiles, coagulation parameters, minerals, blood count parameters, bilirubin levels) and histopathological changes at the level of liver, spleen and pancreas. The experiment was carried out on six groups of male Wistar rats. Hepatic lesions were induced by intraperitoneal injection of carbon tetrachloride (dissolved in paraffin oil, 10% solution). Two mL per 100 g were administered, every 2 days, for 2 weeks. Hepatoprotection was achieved with two apitherapy diet formulations containing honey, pollen, propolis, Apilarnil, with/without royal jelly. Biochemical results reveal that the two apitherapy diet formulations have a positive effect on improving the enzymatic, lipid, and protein profiles, coagulation, mineral and blood count parameters and bilirubin levels. The histopathological results demonstrate the benefits of the two apitherapy diet formulations on reducing toxicity at the level of liver, spleen and pancreas in laboratory animals.

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“…Furthermore, the four herb extracts with superior activity have been reported as medicines for treating diseases. Propolis has been certified to possess a broad spectrum of biological activities such as antioxidative, 21) antitumorial, 22) and antimicrobial. 23) Likewise, a pine bark extract and rosemary extract have been used in traditional medicine for wound healing, 24) DM and stomach problems.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Protective Effects of Chinese Herbs against Biomolecule Damage Induced by Peroxynitrite

Luo

Pan

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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Scavenging action of propolis extract against oxygen radicals

Cited by 144 publications

References 13 publications

Effects of Propolis on Hypoxanthine-Xanthine Oxidase-Induced Toxicity in Cultivated Human Cells and on Neutrophil Elastase Activity

Effects of Propolis on Hypoxanthine-Xanthine Oxidase-Induced Toxicity in Cultivated Human Cells and on Neutrophil Elastase Activity

Effect of Apitherapy Formulations against Carbon Tetrachloride-Induced Toxicity in Wistar Rats after Three Weeks of Treatment

Evaluation of the Protective Effects of Chinese Herbs against Biomolecule Damage Induced by Peroxynitrite

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