Scavenging Activity, Anti-Inflammatory and Diabetes Related Enzyme Inhibition Properties of Leaves Extract from some Varieties of <i>Phoenyx dactylifera l.</i>

Abstract

In this study we investigate the antioxidant, anti-inflammatory, and antidiabetic activities of ethanolic leaves extracts of three selected varieties of Phoenyx dactylifera L. namely: "Ghars", "Deglet Nour" and "Hamraya". The assessment of the antioxidant potential of crude leaves extracts, using superoxide anions inhibition, DPPH and total antioxidant activity essays, was carried out. Furthermore, the anti-inflammatory properties of the extracts were determined by measuring the inhibition of nitric oxide (NO) production. Moreover, the antidiabetic effect was evaluated by inhibition of α-amylase enzymes. The total phenolic content measured by Folin-ciocalteu method was as well conducted. The raw leaves extracts of the selected varieties was found to contain a high content of total phenolic content (342.45 mg GAE/gDW for GE) and therefore exhibited a higher antioxidant activity and inhibitory effect of radicals scavenging activity against DPPH and superoxide anion (IC 50 = 7.44 μg/mL and 39.11 μg/mL respectively). The three varieties exhibited significant inhibition nitric oxide using in-vitro assay (IC 50 = 240.28 μg/mL for GE). The extracts also displayed high inhibition actions against α-amylase enzymes. The results suggest that the leaves of the three selected varieties of Phoenyx dactylifera can be considered as a good source of natural antioxidant and anti-inflammation drugs as well as potent antidiabetic medicine.

Physicochemical characteristics, nutritional composition, and phytochemical profiles of nine Algerian date palm fruit (Phoenix dactyliferaL.) varieties

“…In addition, the IC 50 ’s for DT, DN, and AB ranged from 200 to 400 µg/mL implying that these three varieties served as moderately effective NO scavengers. This was in agreement with the IC 50 for NO scavenging by DN leaves as reported by Eddine, Segni, Noureddine, Redha, and Sonia (). It is interesting to note that DG, LM, and TM exhibited IC 50 ‘ s < 200 µg/mL, which were comparable to the IC 50 shown by green tea (Tsai et al, ).…”

Potentials and Safety of Date Palm Fruit against Diabetes: A Critical Review

“…Following the administration of Ziziphus jujube (jujube date) leaf extract in alloxan-induced diabetic rats, there were significant (p < 0.001) reduction in blood glucose levels (from 767.8 mg/dL to 250.9 mg/dL) although when compared with glibenclamide-administrated group, the difference was not significant as reported by Eddine et al [13]. The mechanism behind this discovery could be hypothesised as due to the contribution of jujube date in stimulating β-cells and activating insulin receptors and subsequently lowering the blood glucose level [97].…”

“…The presence of variable active constituents in dates including flavonoids, steroids, phenol, and saponins are postulated to exert anti-diabetic activities mainly by scavenging the free radicals via antioxidant activities and by inhibiting α-amylase and α-glucosidase enzymes [10][11][12][13]. Fibres and fructose are glucose-lowering, where consumption of dates up to 76.2 g as a snack is purported to be beneficial in Arabic culinary tradition, and can maintain the postprandial glucose levels in patients with diabetes [14,15].…”

Comparative Studies Between Mauritia flexuosa and Mauritiella armata

“…In M. armata and M. flexuosa the leaves exhibited greater antioxidant potential and flavonoid content than the leaves of Calamus rotang (EC 50 of 387,948 μg/mL and flavonoid content of 2.68 EQ mg/g) 30 which is popularly used as antihelmintic and in the treatment of eye problems. 31 However, they have less antioxidant activity than the leaves of Phoenix dactylifera (EC 50 corresponding to 7.44 to Pharmacognosy Journal, Vol 11, Issue 1, Jan-Feb, 2019 12.61 μg/mL), 32 parts of this plant are used in traditional medicine for the treatment of disorders of memory, fever, inflammation, paralysis and its leaves in particular possess antibacterial activity. 33 All these species mentioned belong to the family Arecaceae.…”