sCD30 and Neopterin as Risk Factors of Chronic Renal Transplant Rejection: Impact of Cyclosporine A, Tacrolimus, and Mycophenolate Mofetil

Pretransplant Soluble CD30 Level Has Limited Effect on Acute Rejection, but Affects Graft Function in Living Donor Kidney Transplantation

“…The correlation between sCD30 and graft function is not well documented, but it can be estimated by the previous report that sCD30 is a risk factor for chronic renal transplant rejection (5,16). Our study demonstrated the correlation between pretransplant sCD30 and graft function.…”

Post-Transplant HLA class II Antibodies and High Soluble CD30 Levels are Independently Associated with Poor Kidney Graft Survival

“…Two additional studies in which sCD30 was measured at either 3-5 days (23) or 2 weeks (25) after transplantation also showed that early post-transplant sCD30 levels predict acute rejection. Recent studies by Weimer et al (27,28) have shown high…”

“…A study by Pelzl et al (21) was the first to show that high pre-transplant levels of sCD30 predict poor renal graft outcome. Subsequent studies have confirmed that elevated pre-and early post-transplant (≤1 year) levels of sCD30 predict allograft rejection (acute and chronic) and are associated with poor renal graft function (22)(23)(24)(25)(26)(27)(28). However to date, there are no single or multicenter studies evaluating the relationship of sCD30 measured many years post-transplant to subsequent graft outcome.…”

Association of Elevated Pretransplant sCD30 Levels With Graft Loss in 206 Patients Treated With Modern Immunosuppressive Therapies After Renal Transplantation

“…Therefore, the authors emphasize the relevance of good HLA matching with the donors for these patients. However, there are other studies not confirming the initially clear results regarding a clinical relevance of pretransplant sCD30 levels (6,9).…”

“…However, it has been shown in a large multicenter study that high pretransplant serum levels of soluble CD30 (sCD30), which is a marker for the presence of Th2-type cytokines secreting T-cells, are also associated with allograft rejection (3,4). Moreover, sCD30 levels are increased in patients with rejection episodes after renal transplantation (5)(6)(7). It has also been described that high sCD30 levels in combination with the presence of anti-HLA antibodies before transplantation act as high risk constellation for rejections after kidney transplantation suggesting an additive effect of these factors (8).…”