sCD48 is anti-inflammatory inStaphylococcus aureusEnterotoxin B-induced eosinophilic inflammation

Abstract

SEB regulates CD48 dynamics on eosinophils. Our data indicate sCD48 as a SEB-induced 'decoy' receptor derived from eosinophil and therefore as a potential anti-inflammatory tool in S. aureus-induced eosinophil inflammation often associated with allergy.

CD48 on blood leukocytes and in serum of asthma patients varies with severity

“…To evaluate this possibility, we incubated eosinophils under different conditions and assessed mCD48 expression and sCD48 formation. Eosinophils express mCD48, and in vitro , can form sCD48 in response to SEB or GM‐CSF/PAF activation for 18 h and even after 40 min (Fig. S3).…”

“…Eosinophils have been shown to form sCD48 with either SEB or GM‐CSF/PAF by cell‐associated phospholipase C and phospholipase D . GM‐CSF/PAF is a proinflammatory stimuli present in the asthmatic milieu .…”

“…On MCs and eosinophils, CD48 regulates innate responses to pathogens including Staphylococcus aureus . S. aureus enterotoxin B (SEB) activates eosinophils to form sCD48 by a phospholipase C and D‐linked mechanism . Exogenous sCD48 has anti‐inflammatory activity on SEB activation of eosinophils and in SEB‐induced peritonitis .…”

“…S. aureus enterotoxin B (SEB) activates eosinophils to form sCD48 by a phospholipase C and D‐linked mechanism . Exogenous sCD48 has anti‐inflammatory activity on SEB activation of eosinophils and in SEB‐induced peritonitis . We have previously described that CD48 expression on blood and nasal polyp‐derived eosinophils was increased in eight mild asthmatic patients .…”

Human eosinophils and mast cells: Birds of a feather flock together

“…Activation of 2B4 on eosinophils contributes to cell adhesion and migration and induces degranulation . In vivo activation of human eosinophils by the S. aureus endotoxin B (SEB) leads to the formation of sCD48 and upregulates transcription of CD48 . Interactions between CD48 on MCs and 2B4 on eosinophils are an important part of the physical formation of the AEU and its pro‐inflammatory properties.…”