Scheduled running wheel activity indexes the specificity of pharmocological anorexia

Sensitization of amphetamine-induced wheel running suppression in rats: dose and context factors

“…The nonrunning time graph shows the mean (±SEM) longest continuous period of non-running on the same trials for the same groups of rats (* indicates a significant, P<0.05, difference relative to the other groups) Fig. 5 Mean (±SEM) 1-h log wheel turns over the four counterbalanced test trials for rats who, during acquisition, received either 1 or 5 mg/kg AMP paired with the wheel (groups 1 AMP/SAL and Studies in which indirect stimulants, like AMP, produced a wheel running suppression all involved animals that had, like in this study, very limited wheel experience (Williams and White 1984;Bradbury et al 1987;Geary et al 1992;Masuda et al 1996). Studies which found an elevation of running with stimulant administration largely used animals that either lived in the wheel, had access to the wheel from a side cage (Zeive 1937;Brown and Searle 1938;Searle and Brown 1938;Tainter 1943;Yagi 1963;Evans and Vaccarino 1986;Honma et al 1991;Uchihashi et al 1994;Kosobud et al 1998), or had extensive wheel experience (Irwin et al 1958;Jakubczak and Gomer 1973).…”

“…Other studies have shown that AMP (Williams and White 1984;Bradbury et al 1987;Geary et al 1992) and methamphetamine (Masuda et al 1996) decrease wheel running, while apomorphine initially has little effect on wheel running (Mattingly et al 1997). It is unclear why the acute effects of stimulants on wheel running differ.…”