The minimum hitting set of bundles problem (Mhsb) is a natural generalization of the minimum hitting set problem, where instead of hitting single elements, bundles of elements are hit. More specifically, we are given a ground set of elements and a family of sets. Every set in this family contains bundles of elements, which are subsets of the ground set. The task is to find a collection of elements of minimum size such that at least one bundle of every set in the family is hit. Motivated by several applications, we consider Mhsb restricted to interval and 2-dimensional interval bundles. We study the computational complexity and give polynomial-time algorithms for several classes of instances with these special structured bundles.