Schiff-base reaction induced selective sensing of trace dopamine based on a Pt41Rh59 alloy/ZIF-90 nanocomposite

Abstract

Zeolitic imidazole frameworks (ZIFs) are a new class of functional porous materials with attractive characters, such as gas storage, selective separation, catalysis, and drug delivery. We report herein using nanoscale ZIF-90 crystals with free aldehyde group of imidazole-2carboxaldehyde (ICA) ligand for the selective electrochemical detection of dopamine. The averaged adsorption enthalpy ΔH (i.e., isosteric heat) of ZIF-90 to dopamine is estimated as 72 kJ mol −1 according to grand canonical Monte Carlo (GCMC) simulation. With further modification of a Pt 41 Rh 59 alloy nanocatalyst, the electrochemical sensing performances towards dopamine are improved. The synergetic effect generated by a Pt 41 Rh 59 /ZIF-90 nanocomposite endows it a low detection limit of 1 nM and good specificity. The different anti-interference mechanisms to coexisting redox active species and amino analogues are also included in this work. The strategy demonstrated here may be extended to tune metal nodes as well as ligands of ZIFs crystals and further regulating their functionalities for different target molecules identification.

Design and Application of Metal Organic Framework ZIF-90-ZnO-MoS2 Nanohybrid for an Integrated Electrochemical Liquid Biopsy

“…The bands in the spectral region of 600−1500 cm −1 are associated with the stretching and bending modes of the imidazole ring. 5,23 Importantly, a characteristic peak at about 1675 cm −1 reveals the presence of −CHO, 24,25 confirming our capability on direct immobilization of recognition elements. These characterizations confirmed the chemical identity and structure of the programmed sensing materials.…”

“…Fourier-transform infrared spectroscopy (FT-IR) was further performed (Figure h) and all the peaks in the spectrum of ZIF-90-ZnO-MoS 2 sample are in excellent agreement with that of pure ZIF-90, and no characteristic peak derived from 2-ICA ligand is present, indicating the successful transformation of 2-ICA to ZIF-90 instead of simple surface absorption. The bands in the spectral region of 600–1500 cm –1 are associated with the stretching and bending modes of the imidazole ring. , Importantly, a characteristic peak at about 1675 cm –1 reveals the presence of −CHO, , confirming our capability on direct immobilization of recognition elements. These characterizations confirmed the chemical identity and structure of the programmed sensing materials.…”

Encoding sensing functions into material interface for a rationally engineered integrated electrochemical liquid biopsy

“…2h) and all the peaks in the spectrum of MoS2/ZnO/ZIF-90 sample are in excellent agreement with that of pure ZIF-90 and no characteristic peak derived from 2-ICA ligand is present, indicating the successful transformation of 2-ICA to ZIF-90 instead of simple surface absorption. The bands in the spectral region of 600-1500 cm -1 are associated with the stretching and bending modes of the imidazole ring 19,20 . Most importantly, the characteristic peak at about 1675 cm -1 reveals the presence of -CHO in materials 21,22 , confirming our capability on direct immobilization of recognition elements.…”

Applications of Functional Metal‐Organic Frameworks in Biosensors

“…[ 55 ] Modification of ZIF‐90 with Pt 41 Rh 59 alloy nanocatalyst, the composite had an enhanced electrochemical sensing through Schiff‐base reaction toward dopamine, with a low detection limit of 1 nM with high selectivity. [ 56 ] AuPt nanoparticles decorated hemin loaded Fe‐MIL‐88‐NH 2 composite as a signal amplification mediator and the carrier of HRP‐conjugated affinipure goat anti‐mouse antibody for the detection of maduramicin. [ 57 ] With the synergistic catalytic effect of hemin@MOFs, AuPt nanoparticles, and HRP, a low detection limit of 0.015 ng mL −1 were achieved.…”