Schiff bases and their metal complexes as urease inhibitors – A brief review

Fátima, Ângelo de; Pereira, Camila de Paula; Olímpio, Carolina Raquel Said Dau Gonçalves; Oliveira, Breno Germano de Freitas; Franco, Letícia Paiva; Silva, Pedro Henrique Corrêa da

doi:10.1016/j.jare.2018.03.007

Cited by 137 publications

(49 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compounds with thiol functional groups inhibit urease competitively in their thiolate anion form, R-S − [13]. Imine derivatives of organic compounds have been extensively employed as ligands for several ions, and have been utilized as pigments, catalysts, drugs, and polymer stabilizers [14]. The interested drug candidate can be designed and synthesized via a Schiff base skeleton either through insilico/bioinformatics study or by synthesizing analogues that are structurally close to the reference drug.…”

Section: Introductionmentioning

confidence: 99%

Symmetrical Heterocyclic Cage Skeleton: Synthesis, Urease Inhibition Activity, Kinetic Mechanistic Insight, and Molecular Docking Analyses

et al. 2019

View full text Add to dashboard Cite

The present study focuses on the design and synthesis of a cage-like organic skeleton containing two triazole rings jointed via imine linkage. These molecules can act as urease inhibitors. The in-vitro urease inhibition screening results showed that the combination of the two triazole skeleton in the cage-like morphology exhibited comparable urease inhibition activity to that of the reference thiourea while the metallic complexation, especially with copper, nickel, and palladium, showed excellent activity results with IC50 values of 0.94 ± 0.13, 3.71 ± 0.61, and 7.64 ± 1.21 (3a–c), and 1.20 ± 0.52, 3.93 ± 0.45, and 12.87 ± 2.11 µM (4a–c). However, the rest of compounds among the targeted series exhibited a low to moderate enzyme inhibition potential. To better understand the compounds’ underlying mechanisms of the inhibitory effect (3a and 4a) and their most active metal complexes (3b and 4b), we performed an enzymatic kinetic analysis using the Lineweaver–Burk plot in the presence of different concentrations of inhibitors to represent the non-competitive inhibition nature of the compounds, 3a, 4a, and 4b, while mixed type inhibition was represented by the compound, 3b. Moreover, molecular docking confirmed the binding interactive behavior of 3a within the active site of the target protein.

show abstract

Section: Introductionmentioning

confidence: 99%

Symmetrical Heterocyclic Cage Skeleton: Synthesis, Urease Inhibition Activity, Kinetic Mechanistic Insight, and Molecular Docking Analyses

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The urease inhibitors presented here are organized into five classes according to their chemical structures, namely: (thio)urea derivatives, five- and six-membered heterocycles, barbituric analogues and phosphoramidated substances. Urease inhibitors derived from natural products and metal complexes will not addressed in this review since very good reviews of these compounds have been published elsewhere [6] , [47] .…”

Section: Introductionmentioning

confidence: 99%

A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria

Rego

Queiroz

Brito

et al. 2018

Journal of Advanced Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…Eurasian Chemical Communications applied in nonlinear optical materials [7], corrosion inhibitors [8], and synthesis of nano-compounds [9][10][11][12]. Some of them have also inhibitory activities against αglucosidase [13], carbonic anhydrase [14,15], urease [16], cholinesterase [17], glutathione reductase [18]. Schiff bases also serve as versatile ligands for coordinating a variety of transition metal ions in different coordination geometries and oxidation states [19,20].…”

Section: Original Research Articlementioning

confidence: 99%

Synthesis, characterization, and molecular structure investigation of new tetrahydrobenzo[b]thiophene-based Schiff bases: A combined experimental and theoretical study

2020

Eurasian Chem. Commun.

View full text Add to dashboard Cite

Five new heterocyclic Schiff base derived from tetrahydrobenzo[b]thiophene were synthesized by condensation reaction of 2-amino-4, 5, 6, 7tetrahydrobenzo[b]thiophene-3-carbonitrile with aromatic aldehydes in dimethylformamide containing ZnCl2. The new Schiff bases were characterized on the basis of FT-IR, 1 H NMR, and 13 C NMR spectral data. In addition, the optimized geometries and assignment of the 1 H NMR chemical shifts of the synthesized compounds were computed using the density functional theory (DFT) approaches. Good agreement between the DFT-calculated 1 H NMR chemical shifts and the corresponding experimental values confirms suitability of the optimized geometries for the synthesized Schiff bases. Characteristics of the bonding interactions have been explored using the quantum theory of atoms in molecule (QTAIM) analysis.

show abstract

Schiff bases and their metal complexes as urease inhibitors – A brief review

Abstract: Graphical abstract

Cited by 137 publications

References 85 publications

Symmetrical Heterocyclic Cage Skeleton: Synthesis, Urease Inhibition Activity, Kinetic Mechanistic Insight, and Molecular Docking Analyses

Symmetrical Heterocyclic Cage Skeleton: Synthesis, Urease Inhibition Activity, Kinetic Mechanistic Insight, and Molecular Docking Analyses

A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria

Synthesis, characterization, and molecular structure investigation of new tetrahydrobenzo[b]thiophene-based Schiff bases: A combined experimental and theoretical study

Contact Info

Product

Resources

About