Schisandra chinensis fruit extract attenuates albuminuria and protects podocyte integrity in a mouse model of streptozotocin-induced diabetic nephropathy

Zhang, Mianzhi; Liu, Miao; Xiong, Min; Gong, Junbo; Tan, Xiaoyue

doi:10.1016/j.jep.2012.02.007

Cited by 34 publications

(22 citation statements)

References 34 publications

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“…This result was not consistent with those of the previous in vivo [33] and in vitro [13] studies, which reported significant beneficial effects on obesity. Nevertheless, the obesity-related parameters such as fat mass and blood biomarkers showed interesting correlation with some gut microbiota.…”

Section: Discussioncontrasting

confidence: 99%

Schisandra chinensis fruit modulates the gut microbiota composition in association with metabolic markers in obese women: a randomized, double-blind placebo-controlled study

et al. 2015

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Section: Discussioncontrasting

confidence: 99%

Schisandra chinensis fruit modulates the gut microbiota composition in association with metabolic markers in obese women: a randomized, double-blind placebo-controlled study

et al. 2015

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“…Studies in vivo and in vitro found that glomerular podocytes exposed to high glucose concentration could appear as phenotype transformation, which caused podocytes structure and function injury and proteinuria to be aggravated [1]. Renal biopsy results of diabetic nephropathy patients also confirmed the existence of podocyte phenotype transformation [2, 3]. Podocyte phenotype transformation mainly refers to the pathological state of podocyte epithelial-mesenchymal transition (EMT), which results in loss of podocyte epithelium specificity and damage to podocyte function [4].…”

Section: Introductionmentioning

confidence: 99%

Tangzhiqing Granules Alleviate Podocyte Epithelial‐Mesenchymal Transition in Kidney of Diabetic Rats

Wang

Liu

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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This study discussed the effect of Tangzhiqing granules on podocyte epithelial-mesenchymal transition in kidney of diabetic rats. The diabetic rats were divided randomly into five groups: DM group treated with vehicle, Tangzhiqing granules low-dose treatment group, Tangzhiqing granules middle-dose treatment group, and Tangzhiqing granules high-dose treatment group. Eight Wistar rats used as control group were given saline solution. The intervention was all intragastric administration for 8 weeks. At the end of the 8 weeks, biochemical parameters and kidney weight/body weight ratio were measured. The kidney tissues were observed under light microscope and transmission electron microscopy. To search for the underlying mechanism, we examined the epithelial-to-mesenchymal transition (EMT) related molecular markers and TGF-β/smad signaling pathway key proteins expression. The results showed that Tangzhiqing granules relieved the structural damage and functional changes of diabetic kidneys. Kidney podocyte EMT related molecular markers nephrin and CD2AP expression were increased, when desmin and α-SMA levels were decreased by Tangzhiqing granules in diabetic rats. Further TGF-β/smad signaling pathway key proteins TGF-β1 and p-smad2/3 levels were decreased in diabetic rats after treatment with Tangzhiqing granules. These findings suggest that Tangzhiqing granules may protect the podocytes of diabetic nephropathy rats via alleviating podocyte EMT and likely activating TGFβ/smad signaling pathway.

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“…EMT, a pivotal step in metastasis, induces the transformation from the epithelial to mesenchymal phenotype that increases migratory and invasive abilities of cancer cells (Thiery and Sleeman, 2006; Kalluri and Weinberg, 2009; Martin et al, 2013). The ethanol extract of S. chinensis has been reported to suppress streptozotocin-induced EMT in diabetic nephropathy mice by enhancing E-cadherin expression (Zhang et al, 2012). In general, effect of natural products on the metastatic abilities of cancer cells is determined using non-cytotoxic concentration at proper time course (Liu et al, 2017; Kim et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Gomisin A Suppresses Colorectal Lung Metastasis by Inducing AMPK/p38-Mediated Apoptosis and Decreasing Metastatic Abilities of Colorectal Cancer Cells

et al. 2018

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Gomisin A (G.A) is a dietary lignan compound from Schisandra chinensis. In this study, the effect of G.A on the proliferation and metastasis of colorectal cancer (CRC) cells was investigated using several CRC cell lines and a lung metastasis mouse model. Both oral and intraperitoneal administration of G.A (50 mg/kg) inhibited lung metastasis of CT26 cells. Various concentrations of G.A were incubated with CRC cell lines and their viability was determined using a cell counting kit-8 assay. G.A significantly decreased the viability of various CRC cell lines, whereas it did not change the proliferation of normal colon cells. G.A induced G0/G1 phase arrest and apoptosis of CT26 and HT29 cells by regulating cyclin D1/cyclin-dependent kinase 4 (CDK4) expression and apoptotic proteins such as caspases and B-cell lymphoma-2 (Bcl-2) family proteins, respectively. G.A-induced apoptosis was mediated by AMPK/p38 activation in CRC cells. A non-cytotoxic concentration of G.A inhibited epithelial–mesenchymal transition of CRC cells by modulating E-cadherin and N-cadherin expression levels. Moreover, the migration and invasion of CRC cells were reduced by G.A treatment. Especially, G.A decreased matrix metalloproteinase (MMP)-2 and MMP-9 expressions and activities. G.A ameliorated lung metastasis of CRC cells by decreasing cell survival and metastatic abilities of CRC cells. Thus, G.A might be a potential novel therapeutic agent for metastatic CRC.

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Schisandra chinensis fruit extract attenuates albuminuria and protects podocyte integrity in a mouse model of streptozotocin-induced diabetic nephropathy

Cited by 34 publications

References 34 publications

Schisandra chinensis fruit modulates the gut microbiota composition in association with metabolic markers in obese women: a randomized, double-blind placebo-controlled study

Schisandra chinensis fruit modulates the gut microbiota composition in association with metabolic markers in obese women: a randomized, double-blind placebo-controlled study

Tangzhiqing Granules Alleviate Podocyte Epithelial‐Mesenchymal Transition in Kidney of Diabetic Rats

Gomisin A Suppresses Colorectal Lung Metastasis by Inducing AMPK/p38-Mediated Apoptosis and Decreasing Metastatic Abilities of Colorectal Cancer Cells

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