Schistosoma mekongi infection in a leiomyosarcoma of the small bowel: A case report

Cuesta, Rubén; Kaw, Yao Tek; Duwaji, Mazen S.

doi:10.1016/0046-8177(92)90097-m

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…Two case reports only have pointed to a possible association of infection with S. intercalatum and S. mekongi with cancer (Cuesta et al, 1992, Muller and van der Werf, 2008). S. mekongi infection has been associated with leiomyosarcoma of the small bowel (Cuesta et al, 1992), and intestinal S. intercalatum infection was observed in a patient with rectosigmoid carcinoma (Muller and van der Werf, 2008).…”

Section: Schistosomiasis and Cancermentioning

confidence: 99%

“…S. mekongi infection has been associated with leiomyosarcoma of the small bowel (Cuesta et al, 1992), and intestinal S. intercalatum infection was observed in a patient with rectosigmoid carcinoma (Muller and van der Werf, 2008). However, these two case reports lacked evidence indicating that S. intercalatum and S. mekongi were the causative agents of the observed malignant tumors.…”

Section: Schistosomiasis and Cancermentioning

confidence: 99%

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Parasite Infection, Carcinogenesis and Human Malignancy

et al. 2017

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Cancer may be induced by many environmental and physiological conditions. Infections with viruses, bacteria and parasites have been recognized for years to be associated with human carcinogenicity. Here we review current concepts of carcinogenicity and its associations with parasitic infections. The helminth diseases schistosomiasis, opisthorchiasis, and clonorchiasis are highly carcinogenic while the protozoan Trypanosoma cruzi, the causing agent of Chagas disease, has a dual role in the development of cancer, including both carcinogenic and anticancer properties. Although malaria per se does not appear to be causative in carcinogenesis, it is strongly associated with the occurrence of endemic Burkitt lymphoma in areas holoendemic for malaria. The initiation of Plasmodium falciparum related endemic Burkitt lymphoma requires additional transforming events induced by the Epstein-Barr virus. Observations suggest that Strongyloides stercoralis may be a relevant co-factor in HTLV-1-related T cell lymphomas. This review provides an overview of the mechanisms of parasitic infection-induced carcinogenicity.

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Section: Schistosomiasis and Cancermentioning

confidence: 99%

Section: Schistosomiasis and Cancermentioning

confidence: 99%

Parasite Infection, Carcinogenesis and Human Malignancy

et al. 2017

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“…We did not identify studies of colorectal cancer risk specifically related to S. mekongi in the literature, and believe that our case is the first report of a rectal carcinoma arising in the setting of S. mekongi infection. The only prior case report we identified of a malignancy in the setting of S. mekongi was a case of small bowel leiomyosarcoma, although the authors suggest the possibility that the infection may have been coincidental rather than pathogenically associated [23] .…”

Section: Discussionmentioning

confidence: 99%

Rectal carcinoma arising in a patient with intestinal and hepatic schistosomiasis due to Schistosoma mekongi

Burky

Trembath

Bookhout

2022

IDCases

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Schistosomiasis is a parasitic trematode infection spread by snails with multiple species causing human disease. Infection can cause liver disease, including fibrosis and portal hypertension, and has been linked to malignancies such as bladder and colorectal cancer. We describe a case of Schistosoma mekongi, a geographically limited form of schistosomiasis, in a Laotian immigrant who presented with both hepatic fibrosis and rectal cancer, with numerous schistosome eggs present in the patient’s rectal resection. We believe this case is the first report of a rectal carcinoma arising in the setting of S. mekongi infection.

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