Schistosomiasis: a critical review

Bichler, K.-H.; Feil, G.; Zumbrägel, A.; Eipper, E.; Dyballa, Stephan

doi:10.1097/00042307-200101000-00015

Cited by 22 publications

(6 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been estimated that more than 207 million people are infected and 779 million people are at risk of infection (Steinmann et al 2006). It is the major health risk in the rural areas of China and South East Asia and continues to rank high in other developing countries (Bichler et al 2001). The disease is diagnosed either by the presence of blood in the urine or, in the case of intestinal schistosomiasis, by initially atypical symptoms which can lead to serious complications involving the hepatocellular carcinoma (ElTonsy et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effect of Arctium lappa in Schistosoma haematobium associated kidney disturbance: biochemical and molecular effects

et al. 2015

View full text Add to dashboard Cite

Schistosoma haematobium (S. haematobium) infection has been found to be strongly associated with bladder cancer, which necessitates for discover of a natural new therapeutic agent. The aim of this study was to evaluate the therapeutic effect of Arctium lappa seed extract in S. haematobium associated kidney disturbance. Forty male albino mice were used and divided into four equal groups; group 1 control includes non-infected healthy mice, groups 2, 3 and 4 subcutaneous infected with S. haematobium cercariae. Groups 3 co-treated daily with oral dose of A. lappa seed extract (300 mg/kg, bwt) for 15 days in the same time of S. haematobium infection. Groups 4 post-treated daily for 15 days with oral dose of A. lappa seed extract (300 mg/kg, bwt) after 15 days of S. haematobium infection. The results obtained revealed that S. haematobium significantly decreased kidney weight and serum sodium, potassium and chloride, but increased urinary volume, urinary excretion of sodium, potassium and chloride, serum urea, creatinine and uric acid. Schistosoma haematobium also significantly decreased kidney superoxide dismutase, glutathione peroxidase and reduced glutathione levels while increased kidney lipid peroxidation level. Co-and post-treatment with A. lappa seed extract restore all the above parameters to approach the normal values. These results were supported with histopathological examinations. In conclusion, A. lappa seed extract has therapeutic effect in kidney disturbance caused by S. haematobium where co-treatment of A. lappa seed extract was more effective than post-treatment of the extract.

show abstract

Section: Introductionmentioning

confidence: 99%

Therapeutic effect of Arctium lappa in Schistosoma haematobium associated kidney disturbance: biochemical and molecular effects

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In Sudan the risk for S. haematobium is widespread in the different regions [5-7] and school age children were at a higher risk of S. haematobium infection than the other age groups [6]. Due to many factors such as higher rates of water activities, anatomical vasculature supplying genitourinary structures and immunological factors, school-aged children are the group at highest risk of contracting S. haematobium infection [8-10]. …”

Section: Introductionmentioning

confidence: 99%

Schistosoma haematobium infections among schoolchildren in central Sudan one year after treatment with praziquantel

et al. 2012

View full text Add to dashboard Cite

BackgroundChemotherapy with praziquantel (PZQ) is the mainstay of schistosomiasis control. However, there are recent concerns about tolerance or resistance to PZQ, so that monitoring its efficacy in different settings is required.MethodsA longitudinal study was conducted to evaluate the impact of PZQ for the treatment of Schistosoma haematobium infection among schoolchildren at Al Salamania, Central Sudan. Parasitological examinations for S. haematobium were performed in a cohort of schoolchildren (6–15 years of age) before and 1 year after treatment with a single dose of PZQ 40 mg/kg.ResultsOut of 562 (309 boys and 253 girls) schoolchildren recruited from three elementary schools, 420 completed one longitudinal dataset that comprised of data from two time points; baseline, and follow-up 1 year after treatment with a single dose of PZQ 40 mg/kg for S. haematobium infection. A single dose of PZQ significantly reduced the prevalence of S. haematobium infection by 83.3% (from 51.4% to 8.6%) and the geometric mean intensity of infection of positive individuals by 17.0% (from 87.7 to 72.8 eggs/10 ml of urine) 1 year after treatment. While there was no significant difference in the reduction of the prevalence of S. haematobium infection between the gender or age groups, there was a significantly higher reduction of intensity of S. haematobium infection among girls in comparison with boys.ConclusionThere was a significant reduction of S. haematobium infection 1 year after PZQ treatment in this setting.

show abstract

“…2 It is a helminthic infection of tropical areas where both the native populations and visiting tourists are at risk of infection following contact with fresh water harbouring the intermediate snail host. 3,4 With increasing tourism to both sub-Saharan Africa and South-East Asia, regions where schistosomiasis is known to be endemic, manifestations of this disease in returned travellers are being increasingly recognised. 5 Urinary schistosomiasis is the most common cause of haematuria worldwide, 6 and schistosomal bladder involvement is extremely common.…”

Section: Introductionmentioning

confidence: 99%