Schizophrenia: developmental disturbance of brain and mind?

Stefan, Stefan; Murray, RM

doi:10.1111/j.1651-2227.1997.tb18358.x

Cited by 30 publications

(8 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…58 Other results have shown abnormalities in the temporal lobe and limbic regions, particularly in the left cerebral hemisphere. 58,59 The results of functional brain imaging studies have supported theories of frontal lobe dysfunction, with evidence of reduced metabolic functioning in anterior brain regions. 60 Neuropathological studies have shown a wide array of findings, including a disruption of neuromigration, reflecting abnormalities in fetal brain development.…”

Section: Neuroimaging and Neuropathological Studiesmentioning

confidence: 85%

“…Neuroimaging in schizophrenia has also shown a reversal of the normal pattern of cerebral asymmetries57 and abnormalities of the corpus callosum 58. Other results have shown abnormalities in the temporal lobe and limbic regions, particularly in the left cerebral hemisphere 58,59. The results of functional brain imaging studies have supported theories of frontal lobe dysfunction, with evidence of reduced metabolic functioning in anterior brain regions 60.…”

Section: Neuroimaging and Neuropathological Studiesmentioning

confidence: 92%

See 1 more Smart Citation

Schizophrenia and Attention Deficit Disorder

Barr

2001

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Attentional dysfunction can be found in nearly every form of psychopathology, not just in attention deficit disorder (ADD). Being able to distinguish ADD from other psychiatric conditions is crucial for clinicians working with adolescents and young adults, particularly in the case of psychoses where making the correct diagnosis and beginning treatment promptly is extremely important. In this paper we review the literature on the attentional dysfunction found in schizophrenia and compare it to that found in ADD in an effort to increase our knowledge of etiology and underlying mechanisms. Investigators studying ADD may learn from the study of schizophrenia by realizing that ADD is also a complex disorder of attention that occurs across the developmental spectrum and is characterized by various predispositional, environmental, and maturational factors.

show abstract

Section: Neuroimaging and Neuropathological Studiesmentioning

confidence: 85%

Section: Neuroimaging and Neuropathological Studiesmentioning

confidence: 92%

Schizophrenia and Attention Deficit Disorder

Barr

2001

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

show abstract

“…Furthermore, the relationship between certain viruses and schizophrenia should not be ruled out, even if neither serological evidence nor virus genome was detected in parallel with the course of the illness itself. It is hypothesized in neurodevelopmental theory in relation to maternal infection by influenza during pregnancy [32][33][34] that compromised neural development in the fetus may contribute to the liability to schizophrenia in later life. In this mechanism, neither serological nor genomic evidence is theoretically expected, since direct infection of the host's (fetus's) CNS does not necessarily occur.…”

Section: Discussionmentioning

confidence: 99%

No Changes in Paired Viral Antibody Titers during the Course of Acute Schizophrenia

Fukuda¹,

Sasaki²,

Nanko³

1999

Neuropsychobiology

View full text Add to dashboard Cite

Although there have been many studies surveying the prevalence of specific viral antibodies in a large cohort of patients with schizophrenia, changes in antibody levels during the course of acute illness have not been fully investigated. We conducted a preliminary study investigating levels of antibodies to 5 herpesviruses (herpes simplex virus type 1, cytomegalovirus, Epstein-Barr virus, varicella-zoster virus and human herpesvirus type 6) and 6 other viruses (measles, rubella, mumps, influenza A and B and Japanese encephalitis viruses) in paired sera of 8 patients with acute onset or exacerbation of schizophrenia. Assay for specific immunoglobulin M (IgM) antibody was also performed for herpesviruses and mumps. Neither any relevant change in antibody levels nor appearance of specific IgM antibody was observed for any of the viruses in any of the patients investigated. It is unlikely that the active infection or reactivation of these viruses has direct causal relationship to schizophrenia in these patients.

show abstract

“…The view of schizophrenia as a neurodevelopmental disorder [83][84][85] is a revival of the ideas already present in the era of high-risk research, i.e. longitudinal follow-up studies of offspring of patients with schizophrenia [83,86,87] .…”

Section: Biological Considerationsmentioning

confidence: 99%

Core of Schizophrenia: Estrangement, Dementia or Neurocognitive Disorder?

Urfer-Parnas¹,

Mortensen²,

Parnas³

2010

Psychopathology

View full text Add to dashboard Cite

Background: The recent literature frequently represents schizophrenia as a deteriorating neurocognitive process similar to organic degenerative dementia. Methods: This study addresses the following questions: (1) Did the classic authors equate degenerative dementia with schizophrenia? (2) Is there empirical evidence pointing to a close similarity between schizophrenia and organic dementia? (3) Does empirical evidence support the view that intellectual impairment and/or more specific neuropsychological dysfunctions are core features of schizophrenia? The classic authors agreed that the intellectual dysfunctions were most likely a consequence rather than a primary, causal factor in the manifestation of schizophrenia despite their consensus on the assumption of its neurobiological origins. Rather, they considered impairments of intelligence and neurocognition as an expression of pseudodementia, i.e. a dementia-like clinical picture caused by a weakening of motivation. Results: The empirical data from the draft, high-risk birth cohort and clinical samples show a low IQ and a variety of neurocognitive dysfunctions in schizophrenia. These findings are far from universal since substantial proportions of patients do not show deficits. In addition, the empirical morphological and neuropathological evidence does not support any close analogy of schizophrenia with neurodegenerative dementia. Moreover, neurocognitive dysfunctions cannot be considered a core feature of schizophrenia if core is understood as ‘essential’, i.e. constitutive of a diagnosis, or as ‘generative’, i.e. symptom producing. In the phenomenological psychopathological tradition, schizophrenia is seen as a progressive condition marked by autism, which is a profound alteration in the structures (frameworks) of subjectivity (consciousness), manifest in self-relation (self-disorders) and in the relation to the world (lack of natural evidence) and to others (eccentricity, solipsism and isolation). Conclusion: It is suggested that the neurodevelopmental model should integrate interactions between emerging psychological structures and genetic and environmental factors.

show abstract

Schizophrenia: developmental disturbance of brain and mind?

Cited by 30 publications

References 59 publications

Schizophrenia and Attention Deficit Disorder

Schizophrenia and Attention Deficit Disorder

No Changes in Paired Viral Antibody Titers during the Course of Acute Schizophrenia

Core of Schizophrenia: Estrangement, Dementia or Neurocognitive Disorder?

Contact Info

Product

Resources

About