Schizophrenia-like psychosis associated with right lacunar thalamic infarct

Crail-Meléndez, Daniel; Atriano-Mendieta, C; Carrillo-Meza, R; Ramı́rez-Bermúdez, Jesús

doi:10.1080/13554794.2011.654211

Cited by 24 publications

(13 citation statements)

References 25 publications

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“…Recent studies support this mechanism: the neurotoxic effects of ketamine in rodents appears to occur through action in the thalamus, as opposed to direct effects on cortical brain regions (Sharp et al 2001); reductions in thalamic blood flow have been shown to occur following administration of the serotonergic hallucinogen psilocybin (Carhart-Harris et al 2012); and several case reports of patients with thalamic infarct describe the sudden onset of a schizophrenia-like psychosis (Arikan et al 2009;Mittal and Khan. 2010;Crail-Melendez et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Glutamate, N-acetyl aspartate and psychotic symptoms in chronic ketamine users

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Glutamate, N-acetyl aspartate and psychotic symptoms in chronic ketamine users

et al. 2013

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“…The thalamus plays a critical role in the coordination of information as it passes between several brain regions . A disruption of that information flow may give rise to some of the cardinal symptoms of SCZ and BD, as suggested by previous studies showing: (1) altered thalamic volumes in BD and SCZ patients; (2) reduced neuronal density in post‐mortem thalamic samples of SCZ patients; (3) altered thalamic glutamate receptor expression and elevated dopamine in thalamic sub‐regions; (4) emergence of SCZ‐like syndromes when illnesses, such as stroke, selectively damage the thalamus while sparing the rest of the brain …”

Section: Discussionmentioning

confidence: 99%

The effect of psychosis associated CACNA1C, and its epistasis with ZNF804A, on brain function

Tecelão

Mendes

Martins

et al. 2018

Genes Brain and Behavior

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CACNA1C-rs1006737 and ZNF804A-rs1344706 polymorphisms are among the most robustly associated with schizophrenia (SCZ) and bipolar disorder (BD), and recently with brain phenotypes. As these patients show abnormal verbal fluency (VF) and related brain activation, we asked whether the latter was affected by these polymorphisms (alone and in interaction)-to better understand how they might induce risk. We recently reported effects on functional VF-related (for ZNF804A-rs1344706) and structural (for both) connectivity. We genotyped and fMRI-scanned 54 SCZ, 40 BD and 80 controls during VF. With SPM, we assessed the main effect of CACNA1C-rs1006737, and its interaction with ZNF804A-rs1344706, and their interaction with diagnosis, on regional brain activation and functional connectivity (psychophysiological interactions-PPI). Using public data, we reported effects of CACNA1C-rs1006737 and diagnosis on brain expression. The CACNA1C-rs1006737 risk allele was associated with increased activation, particularly in the bilateral prefronto-temporal cortex and thalamus; decreased PPI, especially in the left temporal cortex; and gene expression in white matter and the cerebellum. We also found unprecedented evidence for epistasis (interaction between genetic polymorphisms) in the caudate nucleus, thalamus, and cingulate and temporal cortical activation; and CACNA1C up-regulation in SCZ and BD parietal cortices. Some effects were dependent on BD/SCZ diagnosis. All imaging results were whole-brain, voxel-wise, and familywise-error corrected. Our results support evidence implicating CACNA1C and ZNF804A in BD and SCZ, adding novel imaging evidence in clinical populations, and of epistasis-which needs further replication. Further scrutiny of the inherent neurobiological mechanisms may disclose their potential as putative drug targets.

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“…53 Schizophrenics are thought to be overwhelmed with information and stimuli due to deficient thalamoreticular circuits that may lead to delusion and hallucination. 13,54 Thus, anatomical and functional variations of the thalamus are likely reflected in differences in sensory gating and filtering of information and stimuli that may or may not lead to schizophrenia-like perceptual experiences. Collectively, fast sleep spindle density seems to be a promising and sensitive spectrum marker for schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Sleep Spindles Are Related to Schizotypal Personality Traits and Thalamic Glutamine/Glutamate in Healthy Subjects

Lustenberger

O’Gorman

Pugin

et al. 2014

Schizophrenia Bulletin

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Background: Schizophrenia is a severe mental disorder affecting approximately 1% of the worldwide population. Yet, schizophrenia-like experiences (schizotypy) are very common in the healthy population, indicating a continuum between normal mental functioning and the psychosis found in schizophrenic patients. A continuum between schizotypy and schizophrenia would be supported if they share the same neurobiological origin. Two such neurobiological markers of schizophrenia are: (1) a reduction of sleep spindles (12-15 Hz oscillations during nonrapid eye movement sleep), likely reflecting deficits in thalamocortical circuits and (2) increased glutamine and glutamate (Glx) levels in the thalamus. Thus, this study aimed to investigate whether sleep spindles and Glx levels are related to schizotypal personality traits in healthy subjects. Methods: Twenty young male subjects underwent 2 all-night sleep electroencephalography recordings (128 electrodes). Sleep spindles were detected automatically. After those 2 nights, thalamic Glx levels were measured by magnetic resonance spectroscopy. Subjects completed a magical ideation scale to assess schizotypy. Results: Sleep spindle density was negatively correlated with magical ideation (r = −.64, P < .01) and thalamic Glx levels (r = −.70, P < .005). No correlation was found between Glx levels in the thalamus and magical ideation (r = .12, P > .1). Conclusions: The common relationship of sleep spindle density with schizotypy and thalamic Glx levels indicates a neurobiological overlap between nonclinical schizotypy and schizophrenia. Thus, sleep spindle density and magical ideation may reflect the anatomy and efficiency of the thalamo-cortical system that shows pronounced impairment in patients with schizophrenia.

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Schizophrenia-like psychosis associated with right lacunar thalamic infarct

Cited by 24 publications

References 25 publications

Glutamate, N-acetyl aspartate and psychotic symptoms in chronic ketamine users

Glutamate, N-acetyl aspartate and psychotic symptoms in chronic ketamine users

The effect of psychosis associated CACNA1C, and its epistasis with ZNF804A, on brain function

Sleep Spindles Are Related to Schizotypal Personality Traits and Thalamic Glutamine/Glutamate in Healthy Subjects

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