Schizophrénie et toxoplasmose

Dion, Sarah; Barbe, P; Leman, Samuel; Camus, Vincent; Dimier‐Poisson, Isabelle

doi:10.1051/medsci/2009258-9687

Cited by 2 publications

(2 citation statements)

References 44 publications

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“…Several authors have reported a high prevalence of Toxoplasma antibodies in patients with schizophrenia, although other factors such as genetic may be present in the schizophrenia, different reports have shown that Toxoplasma is somehow associated with cases of schizophrenia. This finding justifies the need to examine the relationship between toxoplasmosis and schizophrenia with pre-clinical and clinical trials aimed to improve prevention and treatment programs in patients with psychiatric illness [71,72]. On the other hand, a meta-analysis of latent Toxoplasma gondii infection in immunocompetent hosts and cryptogenic epilepsy showed a strong association between seroprevalence rates for toxoplasmosis and prevalence rates of epilepsy.…”

Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis of Toxoplasma gondii infection among the Mexican population

et al. 2012

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BackgroundToxoplasmosis is a disease caused by Toxoplasma gondii and at least one-third of the world’s population has detectable T. gondii antibodies. The seroprevalence of T.gondii ranges from 15% to 50% among the Mexican general population. The aim of this work was to determine the mean prevalence and weighted mean prevalence of T. gondii infection, and to evaluate the epidemiological transition of infection in Mexico.MethodsPub Med, Lilacs, Medline, Latindex, Google Scholar data bases were searched to retrieve reports from 1951 up to 2012 regarding prevalence data, diagnostic tests and risk factors of infection among the adult population. Data collection and criteria eligibility was established in order to determine the crude prevalence (proportion of positive cases) of each study, together with weighted population prevalence according to individual research group categories to limit the bias that may impose the heterogeneous nature of the reports. A Forest Plot chart and linear regression analysis were performed by plotting the prevalence of infection reported from each study over a period of sixty years.ResultsA total of 132 studies were collected from 41 publications that included 70,123 individuals. The average mean prevalence was 27.97%, and weighted mean prevalence was 19.27%. Comparisons among different risk groups showed that the weighted prevalence was higher in women with miscarriages (36.03%), immunocompromised patients (28.54%), mentally-ill patients (38.52%) and other risk groups (35.13%). Toxoplasma infection among the Mexican population showed a downward trend of 0.1%/year over a period of sixty years that represents a 5.8% reduction in prevalence.ConclusionsThis analysis showed a downward trend of infection; however, there are individuals at high risk for infection such as immunocompromised patients, mentally-ill patients and pregnant women. Further research is required to provide better prevention strategies, effective diagnostic testing and medical management of patients. Educational efforts are required to avoid the transmission of infection in populations that cannot be controlled by drugs alone.

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Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis of Toxoplasma gondii infection among the Mexican population

et al. 2012

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“…In particular, several epidemiological, behavioral, and neurochemical studies suggested the existence of an association between schizophrenia and past history of infection by T. gondii (da Silva and Langoni, 2009;Dion et al, 2009;Gaskell et al, 2009;Xiao et al, 2009;Yolken et al, 2009;Zhu, 2009). …”

Section: Humansmentioning

confidence: 99%

Toxoplasma in Animals, Food, and Humans: An Old Parasite of New Concern

Cenci‐Goga

Rossitto

Sechi

et al. 2011

Foodborne Pathogens and Disease

142

106

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All hosts, including humans, can be infected by any one of the three forms of the parasite Toxoplasma gondii that correspond to three morphological stages: tachyzoite, bradyzoite, and sporozoite form. Felids are definitive hosts for T. gondii, which is an intracellular pathogen that infects a wide range of warm-blooded intermediate hosts. Toxoplasmosis is a disease where the interest of the diverse medical and veterinary specialties converge. Awareness needs to be increased that toxoplasmosis can induce clinical disease not only in immunocompromised patients or through congenital infections, but also in healthy patients. This is a review article that aims at illustrating why toxoplasmosis should be regarded a veterinary public health issue and how veterinary practitioners can contribute in controlling the infection.

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Schizophrénie et toxoplasmose

Cited by 2 publications

References 44 publications

A systematic review and meta-analysis of Toxoplasma gondii infection among the Mexican population

A systematic review and meta-analysis of Toxoplasma gondii infection among the Mexican population

Toxoplasma in Animals, Food, and Humans: An Old Parasite of New Concern

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