Schizophyllum commune: A fungal cell-factory for production of valuable metabolites and enzymes

Abstract

Schizophyllum commune is a basidiomycete that is capable of producing different valuable metabolites such as schizophyllan-a polysaccharide, ethanol, and lignocellulolytic enzymes. Schizophyllan finds application in the food industry, pharmacy, and oil recovery. It acts as a non-specific stimulator of immune system. It shows bioactivities such as antineoplastic, antibacterial, anti-cancer, anti-inflammatory, and antiparasitic properties. S. commune is capable of producing bioethanol directly in a single step using lignocellulosic biomass. Lignocellulolytic enzymes including cellulase, xylanase, pectinase, laccase, lignin peroxidase, and manganese peroxidase, are also synthesized efficiently by different strains of S. commune. Being a good producer of ligninolytic enzymes, S. commune has been shown to be effective for the degradation of various synthetic dyes. This article reviews the production of schizophyllan, ethanol, and enzymes and the utilization of S. commune for lignocellulose degradation and decolorization of synthetic dyes.

Exopolysaccharides of Fungal Origin: Properties and Pharmaceutical Applications

“…Schizophyllan, produced by the Schizophyllum commune fungus, can be obtained by submerged culture fermentation using various types of sugars and soluble starch substrates and also low-cost lignocellulosic residues, such as corn fiber, rice hull hydrolysate, wheat bran, corn cobs, or corn steep liquor [44].…”

“…Schizophyllan has been shown to be effective in immunomodulatory activities [44]. Lee and Ki [57] investigated the immunomodulatory results of ultrasound-treated schizophyllan implants on RAW264.7 cells embedded in a three-dimensional polyethylene glycol hydrogel.…”

Unveiling Fungi Armor: Fortifying Pisum sativum L. Seeds against Drought with Schizophyllum commune Fries 1815. Polysaccharides

“…[16,17]. The most investigated PSH from S. commune is beta-glucan, schizophyllan, that has been found to exhibit diverse biological effects, including antitumor, immunomodulatory, and antiinflammatory activities [18]. In our previous research we have identified PSHs isolated from Italian (ITA) and Serbian (SRB) strains of S. commune after submerged cultivation as schizophyllan [17] and have proven its anti-acetylcholinesterase and antioxidant properties.…”

Unveiling Fungi Armor: Preliminary Study on Fortifying Pisum sativum L. Seeds against Drought with Schizophyllum commune Fries 1815 Polysaccharide Fractions

“…[ 16 , 17 ]. The most investigated PSH from S. commune is a beta-glucan, schizophyllan, that has been found to exhibit diverse biological effects, including antitumor, immunomodulatory, and anti-inflammatory activities [ 18 ]. In our previous research, we identified PSHs isolated from the Italian (ITA) and Serbian (SRB) strains of S. commune after submerged cultivation as a β-glucan complex [ 17 ] and proved its anti-acetylcholinesterase and antioxidant properties, which makes S. commune a promising candidate for a biopriming agent that can positively influence seed germination and plant growth and development.…”