Exopolysaccharides of Fungal Origin: Properties and Pharmaceutical Applications

Stoica, Roxana Madalina; Moscovici, Mișu; Lakatos, Elena Simina; Cioca, Lucian‐Ionel

doi:10.3390/pr11020335

Cited by 10 publications

(1 citation statement)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is able to produce a variety of useful metabolites and is known to possess various medicinal properties, such as antimicrobial, anti-inflammatory, and antiparasitic characteristics [32]. Previously, we have reported mycologically synthesized silver and copper nanoparticles by utilizing S. commune fungal extracts, which can be used in both medical and non-medical applications due to their potential antibacterial and antibiofilm properties against multidrug-resistant microorganisms [33]. However, there was no information available on the synthesis of AuNPs by utilizing S. commune.…”

Section: Introductionmentioning

confidence: 99%

Biological Synthesis, Characterization, and Therapeutic Potential of S. commune-Mediated Gold Nanoparticles

Alqurashi,

Almalki,

Ibrahim

et al. 2023

Biomolecules

View full text Add to dashboard Cite

Green-synthesized gold nanoparticles demonstrate several therapeutic benefits due to their safety, non-toxicity, accessibility, and ecological acceptance. In our study, gold nanoparticles (AuNPs) were created using an extracellular extract from the fungus Schizophyllum commune (S. commune). The reaction color was observed to be a reddish pink after a 24 h reaction, demonstrating the synthesis of the nanoparticles. The myco-produced nanoparticles were investigated using transmission electron microscopy (TEM), dynamic light scattering (DLS), and UV–visible spectroscopy. The TEM pictures depicted sphere-like shapes with sizes ranging from 60 and 120 nm, with an average diameter of 90 nm, which is in agreement with the DLS results. Furthermore, the efficiency of the AuNPs’ antifungal and cytotoxic properties, as well as their production of intracellular ROS, was evaluated. Our findings showed that the AuNPs have strong antifungal effects against Trichoderma sp. and Aspergillus flavus at increasing doses. Additionally, the AuNPs established a dose-dependent activity against human alveolar basal epithelial cells with adenocarcinoma (A549), demonstrating the potency of synthesized AuNPs as a cytotoxic agent. After 4 h of incubation with AuNPs, a significant increase in intracellular ROS was observed in cancer cells. Therefore, these metallic AuNPs produced by fungus (S. commune) can be used as an effective antifungal, anticancer, and non-toxic immunomodulatory delivery agent.

show abstract

Section: Introductionmentioning

confidence: 99%