Schneiderian Papillomas and Carcinomas: A Retrospective Study with Special Reference to p53 and p16 tumor suppressor gene expression and association with HPV

Cheung, Florence; Lau, Tina W S; Cheung, Leslie K. N.; Li, Albert S. M.; Chow, Shun Kit; Lo, Anthony W.I.

doi:10.1177/014556131008901002

Cited by 52 publications

(50 citation statements)

References 13 publications

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“…Earlier studies have reported diverging results concerning the risk of malignant transformation of 1–53 %, most of which are considerably higher than the 1.35 % that we found in our population-based study [8–10, 17, 18]. This discrepancy may be due to that earlier hospital-based studies from referral centres have dealt with patients with larger or recurrent IP tumours and that earlier studies, not based on a register with complete coverage of the population, (such as the SCR), have not included all IPs.…”

Section: Discussioncontrasting

confidence: 99%

Incidence of IP and risk of malignant transformation in the Swedish population 1960–2010

Elliot

Marklund

Håkansson

et al. 2016

Eur Arch Otorhinolaryngol

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The true incidence of inverted papilloma (IP) is not yet known. From hospital-based studies, its incidence has been estimated to approximately 0.5/100,000 person years. Earlier hospital case studies have shown that IP can undergo a malignant transformation in 1–53 %. The frequency of its malignant transformation on a population basis is unknown. To our knowledge, no standardised incidence ratio (SIR) has been reported for malignancies among IPs. This study aims to investigate these incidences on a population basis. Using the data from the Swedish Cancer Registry (SCR), we have identified patients with IP and patients with Squamous Cell Carcinoma (SCC) diagnosed between 1960 and 2010 in Sweden. Incidence of IP and incidence of SCC among patients with IP and SIR were analyzed. Eight hundred and fourteen patients with IP were identified. The incidence of IPs reported to the SCR increased from 1960 to 2010. In this cohort, SCC was overrepresented, as compared with the general population. The incidence of IP in the Swedish population seems to have increased.

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Section: Discussioncontrasting

confidence: 99%

Incidence of IP and risk of malignant transformation in the Swedish population 1960–2010

Elliot

Marklund

Håkansson

et al. 2016

Eur Arch Otorhinolaryngol

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“…(33) Although these non-keratinizing carcinomas of the sinonasal tract are sometimes designated as Schneiderian carcinomas, high risk HPV infection does not appear to represent a compulsory step in the carcinomatous transformation of a Schneiderian papilloma as has been so widely suspected. (17,18,26,34) Only 1 of 16 (6%) carcinomas arising in association with Schneiderian papillomas was HPV-positive.…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus-related Carcinomas of the Sinonasal Tract

Bishop¹,

Guo²,

Dl³

et al. 2013

American Journal of Surgical Pathology

261

228

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High risk human papillomavirus (HPV) is an established cause of head and neck carcinomas arising in the oropharynx. The presence of HPV has also been reported in some carcinomas arising in sinonasal tract, but little is known about their overall incidence or their clinicopathologic profile. The surgical pathology archives of The Johns Hopkins Hospital were searched for all carcinomas arising in the sinonasal tract from 1995 to 2011, and tissue microarrays were constructed. P16 immunohistochemistry and DNA in situ hybridization for high-risk types of HPV were performed. Demographic and clinical outcomes data were extracted from patient medical records. Of 161 sinonasal carcinomas, 34 (21%) were positive for high risk HPV DNA, including type 16 (82%), type 31/33 (12%), and type 18 (6%). HPV-positive carcinomas consisted of 28 squamous cell carcinomas and variants (15 non- or partially-keratinizing, 4 papillary, 5 adenosquamous, 4 basaloid), 1 small cell carcinoma, 1 sinonasal undifferentiated carcinoma, and 4 carcinomas that were difficult to classify but exhibited adenoid cystic carcinoma-like features. Immunohistochemistry for p16 was positive in 59/161 (37%) cases, and p16 expression strongly correlated with the presence of HPV DNA: 33 of 34 (97%) HPV positive tumors exhibited high p16 expression, whereas only 26 of 127 (20%) HPV negative tumors were p16 positive (p < .0001). The HPV-related carcinomas occurred in 19 men and 15 women ranging in age from 33 to 87 years (mean 54). A trend toward improved survival was observed in the HPV-positive group (hazard ratio=0.58, 95% confidence interval [0.26, 1.28]). The presence of high risk HPV in 21% of sinonasal carcinomas confirms HPV as an important oncologic agent of carcinomas arising in the sinonasal tract. While non-keratinizing squamous cell carcinoma is the most common histologic type, there is a wide morphologic spectrum of HPV-related disease that includes a variant that resembles adenoid cystic carcinoma. The distinctiveness of these HPV-related carcinomas of the sinonasal tract with respect to risk factors, clinical behavior, and response to therapy remains to be clarified.

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“…Overall, these studies suggested that mechanisms other than HPV integration operate in cancer progression and that HPV infection corresponds to an early promotional event in the multistep oncogenesis of SNIP. Subsequent genetic or epigenetic events would be required in order to bring about cellular dysplasia and progression to carcinoma [23,24]. Moreover, detection rates for HPV vary widely in p53, p21, p27…”

Section: Hpvmentioning

confidence: 99%

Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review

Gioacchini

Bajraktari

et al. 2017

Eur Arch Otorhinolaryngol

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Schneiderian papillomas are uncommon tumors which may develop within the nasal cavity and comprise three well-defined histological types: sinonasal inverted papilloma (SNIP), exophytic papilloma, and oncocytic papilloma. It is well known the rate of Schneiderian papilloma may also present a malignant degeneration and SNIP represents the most important subgroup in consideration of its frequency and malignant propensity. Although HPV infection is always considered the first event favoring the development of SNIP, however, it is not established as an eventual connection between viral actions and malignant transformation. In fact, different molecular mechanisms are suspected to play a crucial role in this process and, currently, many authors agree that only by improving our knowledge about these mechanisms it will be possible to achieve new and effective targeted therapies. So the aim of this study was firstly to systematically review the literature focusing on different biomarkers that could be implicated in the stages of SNIP malignant degeneration. Secondly, a systematic review with meta-analysis was performed to better define the incidence of sinonasal malignancies originating from Schneiderian papilloma (SNIP, exophytic papilloma, and oncocytic papilloma). Twenty-nine studies comprising a total of 3177 patients were statistically analyzed. Results showed a 9% (95% CI = 7-11) overall rate of malignant transformation from Schneiderian papilloma. In conclusion, this analysis confirmed that the potential malignancy of Schneiderian papilloma should not be underestimated. On the other hand, our review showed the paucity of studies investigating the molecular alterations which may be related with the malignant transformation of SNIP.

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Schneiderian Papillomas and Carcinomas: A Retrospective Study with Special Reference to p53 and p16 tumor suppressor gene expression and association with HPV

Cited by 52 publications

References 13 publications

Incidence of IP and risk of malignant transformation in the Swedish population 1960–2010

Incidence of IP and risk of malignant transformation in the Swedish population 1960–2010

Human Papillomavirus-related Carcinomas of the Sinonasal Tract

Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review

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