School age outcome of hospitalisation with respiratory syncytial virus infection of prematurely born infants

Greenough, Anne; Alexander, John R.; Boit, Phillipa; Boorman, J; Burgess, S; Burke, Andrew; Chetcuti, Philip; Cliff, Ian; Lenney, Warren; Lytle, Thomas; Morgan, Colin; Raiman, Clare; Shaw, N J; Sylvester, Karl; Turner, Jackie

doi:10.1136/thx.2008.095547

Cited by 51 publications

(72 citation statements)

References 32 publications

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“…Increased clinical care for preterm infants hospitalised with RSV translates to increased morbidity, healthcare utilisation and costs of care for respiratory illnesses later in life [65,66]. Early-life hospitalisation with RSV infection among preterm infants has been associated with more than a 2-fold increase in the mean number of subsequent hospitalisations during the 4 years following the initial infection (1.28 vs. 2.96; P < 0.001), when compared with non RSV-related hospitalisation [67].…”

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

“…Even though the majority of the data on the long-lasting impact of RSV have been based on studies of healthy term-born infants, limited studies have demonstrated increased risk of asthma [68], recurrent wheeze [34,69,70] and lung function impairments [66] in preterm children with a history of RSV-related hospitalisation during infancy. Early-life hospitalisation with RSV infection in preterm infants has been associated with more than twice the risk of ongoing respiratory morbidity, with wheezing rates ranging from 20.7 to 42.8%, 1–2 years following RSV-related hospitalisation compared to 4.1 to 23% following non-RSV related hospitalisation [43].…”

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

“…Early-life hospitalisation with RSV infection in preterm infants has been associated with more than twice the risk of ongoing respiratory morbidity, with wheezing rates ranging from 20.7 to 42.8%, 1–2 years following RSV-related hospitalisation compared to 4.1 to 23% following non-RSV related hospitalisation [43]. The risk of asthma, recurrent wheeze and long-lasting impairments in lung function following severe RSV-related respiratory illness during infancy is more pronounced among preterm infants with BPD [66,71] and those born at a lower gestational age [68]. Although most studies demonstrating persistent respiratory morbidity following RSV-related respiratory illness have focused on hospitalised infants, a single study has demonstrated persistent airway resistance at 1 year of age in preterm infants following mild RSV infection that did not require hospitalisation [72].…”

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

“…Although it is possible that the immature lungs in preterm infants might be particularly susceptible to long-term damage following severe RSV-related respiratory illness during early life [66,73], RSV infection during such a critical period of lung growth and development can also result in chronic alterations and remodelling of the developing airways independent of pre-existing neonatal factors [50,72]. The underlying mechanisms through which RSV could promote the development of suboptimal lung health and function later in life are yet to be fully elucidated.…”

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

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The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased burden of viral respiratory infections is likely to have long term implications for lung health and function in individuals born preterm, particularly those with bronchopulmonary dysplasia. Several hypotheses have been put forward to explain the association between early life viral respiratory infection and development of suboptimal lung health and function later in life following preterm birth. Although preterm infants with diminished lung function, particularly small airways, might be particularly susceptible to asthma and wheezing disorders following viral infection, there is evidence that respiratory viruses can activate number of inflammatory and airway re-modelling pathways. Therefore, the aim of this review is to highlight the perinatal and early life risk factors that may contribute to increased susceptibility to viral respiratory infections among preterm infants during early life and to understand how respiratory viral infection may influence the development of abnormal lung health and function later in life.

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Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

See 2 more Smart Citations

The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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“…Following discharge from the neonatal intensive care unit (NICU), surviving preterm infants with subsequent VRTIs are more likely to develop severe respiratory disease or suffer from recurrent wheeze and asthma [9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Outcomes of Nosocomial Viral Respiratory Infections in High-Risk Neonates

et al. 2016

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A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription.For more information, please contact eprints@nottingham.ac.uk Financial disclosure: The other authors have no financial relationships relevant to this article to disclose. Outcomes of nosocomial viral respiratory infections in high-risk neonates Conflicts of interest:The other authors have no potential conflicts of interest to disclose. Abbreviations:VRTIs -viral respiratory tract infections BPD -bronchopulmonary dysplasia NICU -neonatal intensive care unit NEC -necrotising enterocolitis CPAP -continuous positive airway pressure Bi-PAP -bi-level positive airway pressure HFOV -high frequency ventilation ECMO -extracorporeal membrane oxygenation RT-PCR -real time polymerase chain reaction RVP -respiratory viral panel NHS -National Health Service What's Known on This SubjectViral respiratory tract infections cause severe respiratory morbidity in ex-preterm infants after NICU discharge. They are now recognized to be more prevalent in the NICU but their longterm impact, prior to discharge, during this early period of life is unclear. What This Study AddsThis study identifies the adverse impact viral respiratory infections, particularly rhinovirus, have on newborn infants during their initial NICU admission. Identification of the associated significant respiratory morbidity and healthcare costs should focus efforts on reducing these nosocomially acquired infections. Contributors' Statements:Dr Don Sharkey conceptualized and designed the study, drafted the initial manuscript, and approved the final manuscript as submitted.Drs Shairbanu Zinna, Arthi Lakshmanan, Shin Tan, Shiu Soo, Lisa Szatkowski and Miss Rebecca McClaughry and Mr Martin Clarkson carried out the data collection, initial analyses, reviewed and revised the manuscript, and approved the final manuscript as submitted.All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. ABSTRACTBackground Neonatal respiratory disease, particularly bronchopulmonary dysplasia, remains one of the leading causes of morbidity and mortality in newborn infants. There is increasing evidence that nosocomially acquired viral respiratory tract infections (VRTIs) are not uncommon in the neonatal intensive care unit but there are few studies on their impact on neonatal respiratory outcomes and the associated healthcare costs. This study aimed to assess the association between nosocomial VRTI and neonatal respiratory disease.

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