Schwangerschaft und Geburt bei Mukoviszidose - Resultate der Deutschland Studie*

Abstract

Thirty-one pregnancies in 27 women suffering from mucoviscidosis have been studied in Germany, in the period from 1980 to 1991. This analysis is the largest collection of data to date relating to pregnancy and birth with mucoviscidosis after the American-Canadian study of 1980. The German study demonstrated that only women with few weak symptoms became pregnant: typically the pregnant women's mucoviscidosis was diagnosed at an average age of 9.2 years, and 96.5% of the women had a satisfactory pregravid Shwachman-Kulczicki-Score. Only minor complications were observed in these pregnancies, in particular pulmonary exacerbations (in 18 pregnancies) and an insufficient weight gain (average of 7.2 kg). Abortions were induced in five pregnancies and no spontaneous were observed. There were of maternal deaths during pregnancy or childbirth. More than one quarter of the newborns were premature. All the children had normal sweat chloride test results. 21 women could breast-feed successfully. In fifteen cases the mother's state of health deteriorated after pregnancy however only to a minor (ten cases) or moderate degree (four cases). It is noteworthy that of the twenty six infants twenty one were male. In this study we obtained the unexpected result that unaffected heterocygous children of women with mucoviscidosis are mainly male.

Maternal and Fetal Morbidity in Pregnancies of Norwegian and Swedish Women With Cystic Fibrosis

“…Compared with studies from other European countries the Scandinavian women seem to maintain a better lung capacity during pregnancy, their lung function deteriorating less than in women in previous reports (32,33). In reports from the UK (33,35) a loss of 13% of FEV1 and 11% of FVC during pregnancy was observed.…”

“…Another explanation may be that the women in our study had a larger weight gain (π 10.3 kg) during pregnancy compared with the other European studies (32,33). The weight gain during pregnancy showed a 19% increase, which is within the normal range.…”

“…One mother gave birth to four children, seven mothers had two children, and the remaining 15 mothers had one completed pregnancy each. The first pregnancy occurred at a median age of 27 years (range [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. Five women conceived by assisted reproduction.…”

Prevalence and outcome of pregnancies in Norwegian and Swedish women with cystic fibrosis

“…The miscarriage rate of 15% in the women with CF is approximately as expected in the general population, and is within the 2.6–21.4% range reported previously (23).…”

Maternal and fetal morbidity in pregnancies of Norwegian and Swedish women with cystic fibrosis

“…The question at present, both for the woman and her physician, is how the CF disease will affect her pregnancy and how the pregnancy will affect her health. Previous studies from Europe have described CF pregnancies: 24 live births from Germany (32) and 48 live births from UK (33).…”