2017
DOI: 10.1016/j.conb.2017.10.010
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Schwann cells participate in synapse elimination at the developing neuromuscular junction

Abstract: During the initial stages of innervation of developing skeletal muscles, the terminal branches of axons from multiple motor neurons form neuromuscular junctions (NMJs) on a small region of each muscle fiber, the motor endplate. Subsequently, the number of axonal inputs at the endplate region is reduced so that, at maturity, each muscle fiber is innervated by the terminals of a single motor neuron. The Schwann cells associated with the axon terminals are involved in the removal of these synapses but do not sele… Show more

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Cited by 24 publications
(21 citation statements)
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“…s2). The induced expression of NG2 in NMJ Schwann cells supports previous studies indicating that PSCs originate from Schwann cells 8 . The delayed expression of NG2 ( Fig Previous studies relied solely on a combination of anatomical location and Schwann cell markers to make inferences about the number and spatial arrangement of PSCs at NMJs 9,10 .…”
Section: Resultssupporting
confidence: 89%
“…s2). The induced expression of NG2 in NMJ Schwann cells supports previous studies indicating that PSCs originate from Schwann cells 8 . The delayed expression of NG2 ( Fig Previous studies relied solely on a combination of anatomical location and Schwann cell markers to make inferences about the number and spatial arrangement of PSCs at NMJs 9,10 .…”
Section: Resultssupporting
confidence: 89%
“…Another factor missing in the current models is the third key player for NMJ maturation: Schwann cells. These peripheral glial cells not only nourish MNs through formation of myelin sheaths along their motor axons, but also specialize into the one called terminal Schwann cell, which locally supports NMJ maturation and maintenance ( Sanes and Lichtman, 1999 ; Feng et al, 2005 ; Sugiura and Lin, 2011 ; Darabid et al, 2014 ; Lee et al, 2017 ). Despite multiple studies demonstrating the beneficial effect of Schwann cells on neuroregeneration in conventional co-culture systems ( Ullian et al, 2004 ; Li et al, 2007 ; Gingras et al, 2008 ; Ragancokova et al, 2009 ; Gerardo-Nava et al, 2014 ; Hyung et al, 2015 ; Suh and Hyung, 2018 ), no study has thus far succeeded in incorporating Schwann cells into the in vitro model of NMJs: this difficulty can presumably be overcome by adopting a compartmented culture method as discussed above.…”
Section: Challengesmentioning
confidence: 99%
“…This suggest that pre- and postsynaptic changes are coordinated. Non-myelinating terminal Schwann cells at the NMJ play a role in synapse elimination (reviewed by Lee et al, 2017 ). A model has been proposed in which the activity of the Schwann cells promote synapse elimination by creating vacant synaptic sites that can be reoccupied by the competing axon terminals.…”
Section: Adenosine Receptors Role During Developmentmentioning
confidence: 99%