Schwannoma arising in mediastinal lymph node diagnosed by endobronchial ultrasound

Kang, Lae Hyung; Shin, Dong Hoon; Yoon, Seong Hoon

doi:10.1002/rcr2.481

Cited by 6 publications

(6 citation statements)

References 16 publications

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“…[ 2 ] The diagnosis of schwannoma is usually based on findings from examination of the surgical specimen. [ 9 ] For patients who require preoperative diagnosis, an incisional biopsy obtained through minimally invasive surgery is preferred. [ 2 ] However, some reports have described EBUS-TBNA, endoscopic ultrasound-guided fine-needle aspiration, and transthoracic biopsy for the diagnosis of schwannomas, and diagnosis based on these small specimens is consistent with that of surgical specimens.…”

Section: Discussionmentioning

confidence: 99%

“…[2] However, some reports have described EBUS-TBNA, endoscopic ultrasound-guided fine-needle aspiration, and transthoracic biopsy for the diagnosis of schwannomas, and diagnosis based on these small specimens is consistent with that of surgical specimens. [2,[8][9][10][11][12]16,[23][24][25] When properly prepared, cell blocks obtained from EBUS-TBNA enable cytological examination and immunocytochemical staining, which can confirm the diagnosis of schwannomas. However, when spindle cells are encountered in small specimens (e.g., TBNA), it is difficult to make a definitive diagnosis based on cytological features in some cases because a broad differential diagnosis is needed.…”

Section: Discussionmentioning

confidence: 99%

“…In particular, the use of EBUS-TBNA to diagnose schwannomas has not been frequently reported. [8–12] Herein, we report a case involving a patient with schwannomas diagnosed using EBUS-TBNA and confirmed by pathological analysis of surgical specimens.…”

Section: Introductionmentioning

confidence: 92%

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Endobronchial ultrasound-guided transbronchial needle aspiration as a diagnostic modality for schwannoma: A case report

Liu

Chen

et al. 2022

Medicine

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Introduction: Schwannomas are the most common nerve sheath tumors in the paravertebral mediastinum. Although radiological imaging is helpful in diagnosing schwannomas, a definitive diagnosis is dependent on pathological features of a surgical specimen. For patients who require preoperative diagnosis, an incisional biopsy using minimally invasive surgery is preferred. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is less commonly used for suspected schwannomas. Patient concerns: A 48-year-old woman presented to the clinic with complaints of productive cough for >1 month, expectorating yellow and mucoid sputum approximately 4 to 5 times per day. Chest computed tomography revealed a well-circumscribed, homogeneous, soft tissue mass lesion in right upper posterior mediastinum, measuring 55 mm × 44 mm. Vocal fremitus in the right upper lung was diminished, the percussion note was slightly dull, and breath sounds were slightly reduced on auscultation. The patient was a nondrinker and nonsmoker, with no other relevant medical history. There was no significant relevant family medical history. Diagnosis: Complete blood count and blood biochemistry were within normal limits, except for an elevated erythrocyte sedimentation rate (32 mm/h). EBUS-TBNA was performed and histopathological findings were consistent with schwannoma. Interventions: The patient underwent schwannoma excision by thoracoscopy. Pathological findings from the surgical specimen were consistent with the EBUS-TBNA results. Based on EBUS-TBNA and postsurgical pathology, the patient was diagnosed with a right upper mediastinal schwannoma (Antoni B). Outcomes: The patient experienced an uneventful postoperative recovery with no adjuvant therapy and was discharged on April 18, 2017. The patient has been followed up for 4 years and has not experienced any symptoms. Conclusions: Cell blocks obtained from EBUS-TBNA afford the possibility of cytological examination and immunocytochemical staining, which can confirm diagnosis of schwannoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Endobronchial ultrasound-guided transbronchial needle aspiration as a diagnostic modality for schwannoma: A case report

Liu

Chen

et al. 2022

Medicine

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“…Depending on mass localization, other diagnosis tools can be used. Kang et al presented a mediastinal lymph node schwannoma, diagnosed using endobronchial ultrasound [14].…”

Section:  Discussionmentioning

confidence: 99%

Cervical intranodal schwannoma – a rare diagnosis

Mirea

Manea²,

Bejinariu³

et al. 2022

Rom J Morphol Embryol

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Intranodal schwannoma is a rare benign tumor, which originates from the peripheral nerve sheath (Schwann cells), fewer cases being reported with lymphatic involvement. We present the case of a middle-aged female patient, with one-year growing mass in the lateral-cervical area, in intimate relation with the vascular package of the neck. Preoperative cervical computed tomography examination showed the tumor features. There was no intraoperative complication, with the piece being completely removed. The morphological examination revealed the structure of a lymph node, and after Hematoxylin-Eosin staining, there were eosinophilic cytoplasm, euchromatic nuclei, with round, elongated or slightly wavy form and reduced pleomorphism, rare degenerative nuclear atypia, and no mitotic activity nor necrosis. The expression of S100 protein on immunohistochemistry, along with negative results for smooth muscle actin and desmin sustained the diagnosis of intranodal schwannoma of the neck. With a low index of cellular proliferation (Ki67), this case is in line with the reported features of schwannoma having extremely rare malignant transformation.

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“…4 For comparison to other nerve sheath tumors, there are 16 reported cases of schwannoma involving the lymph nodes. [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] Lymph node involvement is considered very uncommon in MPNST unless widely metastatic disease is present. 11,12 Benign granular cell tumor occurring in lymph nodes is described as rare by Enzingar and Weiss.…”

Section: Discussionmentioning

confidence: 99%

Intranodal Neurofibroma: A Case Report and Literature Review

Adams¹,

Huston²,

Lozeau

2022

The American Journal of Dermatopathology

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Purpose:To report a case of neurofibroma involving the lymph nodes and to perform a literature review on this topic.Observations:A 72-year-old woman with a history of neurofibromatosis and biopsy-proven malignant melanoma of the left forearm underwent wide local excision of the malignant lesion along with sentinel axillary lymph node biopsy. Histological examination of axillary nodes revealed diffuse neurofibromatosis within 2 lymph node capsules. A thorough review of the English literature pertaining to intranodal neurofibroma was performed by querying Google Scholar and PubMed. Only 5 cases of intranodal neurofibroma have been described until now.Conclusions and Importance:Neurofibroma involving the lymph nodes is rare and this is the first reported case that is shown to diffusely involve the intracapsular space. Furthermore, intranodal neurofibroma can represent a diagnostic pitfall in the evaluation of sentinel lymph nodes for metastatic melanoma.

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Schwannoma arising in mediastinal lymph node diagnosed by endobronchial ultrasound

Cited by 6 publications

References 16 publications

Endobronchial ultrasound-guided transbronchial needle aspiration as a diagnostic modality for schwannoma: A case report

Endobronchial ultrasound-guided transbronchial needle aspiration as a diagnostic modality for schwannoma: A case report

Cervical intranodal schwannoma – a rare diagnosis

Intranodal Neurofibroma: A Case Report and Literature Review

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