2004
DOI: 10.1016/j.brainres.2004.08.036
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Sciatic nerve regeneration in mice and rats: recovery of sensory innervation is followed by a slowly retreating neuropathic pain-like syndrome

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Cited by 97 publications
(59 citation statements)
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“…The motor function recovery of sciatic nerve in this study was in agreement with the previous study which had reported that the motor function recovery in the foot showed fully recovery after sciatic nerve crush injury within 3 weeks (Vogelaar et al, 2004). It has been reported that after nerve crush injury, the neuropathic pain which manifested as allodynia has been developed within the first 3 weeks (Attal et al, 1994;Kingery et al, 1994;Przewlocki et al, 1999;Vogelaar et al, 2004). Thus, the slow recovery process of the sensory nerve observed in this study may occur partly due to the development of neuropathic pain which takes much longer to resolve.…”
Section: Discussionsupporting
confidence: 93%
“…The motor function recovery of sciatic nerve in this study was in agreement with the previous study which had reported that the motor function recovery in the foot showed fully recovery after sciatic nerve crush injury within 3 weeks (Vogelaar et al, 2004). It has been reported that after nerve crush injury, the neuropathic pain which manifested as allodynia has been developed within the first 3 weeks (Attal et al, 1994;Kingery et al, 1994;Przewlocki et al, 1999;Vogelaar et al, 2004). Thus, the slow recovery process of the sensory nerve observed in this study may occur partly due to the development of neuropathic pain which takes much longer to resolve.…”
Section: Discussionsupporting
confidence: 93%
“…Using the CatWalk-automated gait analysis method, we found that focal ischemia led to a persistent reduction in paw pressure and maximal area of paw contact. These gait impairments are likely because of an altered use of the plantar surface of the paw, a pattern commonly observed in other models of central nervous system injury including sciatic nerve resection, spinal cord injury, Parkinson's disease, and pain (Gabriel et al, 2007;Gensel et al, 2006;Vlamings et al, 2007;Vogelaar et al, 2004). The absolute values and impairment in foot print intensity and paw contact area were always greater in the forepaws than hindpaws of ischemic rats, possibly because the forepaws play a more important role in supporting the body weight during walking.…”
Section: Comparing Gait Impairments After Ischemic Stroke With Other mentioning
confidence: 99%
“…In sciatic nerve crushed injury model, Vogelaar et al (2004) reported that although sensory and motor reinnervation of the paw are fully established after nerve injury, persistent pain still exists and the animals can not support their weight on the injured paw. In the acute stage of sciatic crushed nerve injury, we observed that the flexion contracture of the toes and a curvation of the feet make impossible to calculate SFI in some rats.…”
Section: Discussionmentioning
confidence: 99%