Gender medicine is a new and challenging field of research which arouses increasing public interest and is going to affect more and more clinical practice. There is increasing evidence of gender-related differences in risk factors, clinical manifestation, and sequelae of diseases and increasing knowledge that prevention, detection, and therapy of illness affect men and women differently. Broad-minded clinicians and health professionals try to consider the different health needs of women and men. The increase of gender awareness is also reflected in several articles concerning sex-and gender-differences in the various fields of medicine and professional journals in addition to the journals relevant to this specific science. Therefore, it is not surprising that other fields of research than public health or cardiology, which traditionally engaged in gender medicine, are increasingly addressing sex-and gender-based differences. For example an actual scientific literature search in PubMed with the term Gender medicine resulted in 29837 publications including 1894 review articles. The terms gender differences showed 104176 articles, sex differences 134079 and gender bias 22317 publications. On the other hand, Womens health resulted in 306274, but Mens health in only 3107 citations. Gender medicine developed from womens health but also broadened the field of womens health including the wide range of health conditions that affect women beyond sexual and reproductive health and throughout the life course. Furthermore, the gender approach also prepared scientists and clinicians for more thorough engagement in mens health.In particular, gender medicine in the field of endocrinology and metabolism is rapidly expanding. Indeed endocrinology is one of the core subjects of gender-based medicine in general and therefore a regular section devoted to endocrinology was recently introduced to the journal specifically devoted to gender medicine, the Journal of Gender Medicine, founded by Marianne Legato in 2004 [1]. Sex-and gender-differences play an important role in pathophysiology, clinical picture, development of complications and in part also regarding therapy of metabolic disorders affecting life-quality and life-expectancy [2,3]. It is comprehensible that lifestyle-diseases such as obesity and type 2 diabetes are of special interest to sex-and gender-based medicine. Not only genes, sex-specific hormones, and body fat distribution combined with sex-related changes of adipocytokines, but also environmental exposures and psychosocial factors obviously contribute to progression of the diseases [4,5]. However, many other diseases such as immunologic diseases and allergies, but also degenerative diseases, neurologic and psychologic diseases show important sex-and gender-based differences [6]. In addition, knowledge on differences in drug-response and side reactions following drug therapy is still insufficient and there is need for randomized clinical trials addressing these questions and powered to answer these question in the futu...