Science dialogue mapping of knowledge and knowledge gaps related to the effects of dairy intake on human cardiovascular health and disease

Brown, Andrew W.; Kaiser, Kathryn A.; Keitt, Andrew; Fontaine, Kevin R.; Gibson, Madeline; Gower, Barbara A.; Shikany, James M.; Vorland, Colby J.; Beitz, Donald C.; Bier, Dennis M.; Brenna, J. Thomas; Jacobs, David R.; Kris-Etherton, Penny M.; Maki, Kevin C.; Miller, Michael; St‐Onge, Marie‐Pierre; Terán-García, Margarita; Allison, David B.

doi:10.1080/10408398.2020.1722941

Cited by 2 publications

(1 citation statement)

References 67 publications

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“…Diet differs considerably between different continents and countries. Both diet and ethnicity with genetic variants have been shown to influence the development of cardiovascular disease [21][22][23][24]. Thus, a result obtained in one population cannot be predicted to occur in another population.…”

Section: Introductionmentioning

confidence: 99%

The effect of aged garlic extract on the atherosclerotic process – a randomized double-blind placebo-controlled trial

Wlosinska

Nilsson

Hlebowicz

et al. 2020

BMC Complement Med Ther

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Background One of the most serious secondary manifestations of Cardiovascular Disease (CVD) is coronary atherosclerosis. This study aimed to evaluate whether aged garlic extract (AGE) can influence coronary artery calcification (CAC) and to predict the individual effect of AGE using a standard process for data mining (CRISP–DM). Method This was a single-center parallel randomized controlled study in a university hospital in Europe. Patients were randomized, in a double-blind manner, through a computer-generated randomization chart. Patients with a Framingham risk score ≥ 10 after CT scan (n = 104) were randomized to an intake of placebo or AGE (2400 mg daily) for 1 year. Main outcome measures were changes in CAC score and secondary outcome measures changes in blood pressure, fasting blood glucose, blood lipids and inflammatory biomarkers. Result 104 patients were randomized and 46 in the active group and 47 in the placebo group were analyzed. There was a significant (p < 0.05) change in CAC progression (OR: 2.95 [1.05–8.27]), blood glucose (OR: 3.1 [1.09–8.85]) and IL-6 (OR 2.56 [1.00–6.53]) in favor of the active group. There was also a significant (p = 0.027) decrease in systolic blood pressure in the AGE group, from a mean of 148 (SD: 19) mmHg at 0 months, to 140 (SD: 15) mmHg after 12 months. The AGE Algorithm, at a selected probability cut-off value of 0.5, the accuracy score for CAC progression was 80%, precision score of 79% and recall score 83%. The score for blood pressure was 74% (accuracy, precision and recall). There were no side-effects in either group. Conclusions AGE inhibits CAC progression, lowers IL–6, glucose levels and blood pressure in patients at increased risk of cardiovascular events in a European cohort. An algorithm was made and was used to predict with 80% precision which patient will have a significantly reduced CAC progression using AGE. The algorithm could also predict with a 74% precision which patient will have a significant blood pressure lowering effect pressure using AGE. Trial registration Clinical trials NCT03860350, retrospectively registered (1/32019).

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Section: Introductionmentioning

confidence: 99%

The effect of aged garlic extract on the atherosclerotic process – a randomized double-blind placebo-controlled trial

Wlosinska

Nilsson

Hlebowicz

et al. 2020

BMC Complement Med Ther

View full text Add to dashboard Cite

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Science dialogue mapping of knowledge and knowledge gaps related to the effects of dairy intake on human cardiovascular health and disease

Brown

Kaiser

Keitt

et al. 2020

Critical Reviews in Food Science and Nutrition

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Dairy has been described as everything from a superfood to a poison; yet, arguments, assumptions, and data justifying these labels are not always clear. We used an issue-based information system, "dialogue mapping™," to summarize scientific points of a live panel discussion on the putative effects of dairy on cardiovascular diseases (CVD) from a day-long session among experts in nutrition and CVD. Dialogue mapping captures relations among ideas to explicitly, logically, and visually connect issues/questions, ideas, pro/con arguments, and agreements, even if discussed at different times. Experts discussed two propositions: for CVD risk, consumption of full-fat dairy products, 1) should be minimized, in part because of their saturated fat content, or 2) need not be minimized, despite their saturated fat content. The panel discussed the dairy-CVD relation through blood lipids, diabetes, obesity, energy balance, blood pressure, dairy bioactives, biobehavioral components, and other putative causal pathways. Associations and effects reported in the literature have varied by fat content of dairy elements considered, study design, intake methods, and biomarker versus disease outcomes. Two conceptual topics emerged from the discussion: 1) individual variability: whether recommendations should be targeted only to those at high CVD Brown et al.

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Science dialogue mapping of knowledge and knowledge gaps related to the effects of dairy intake on human cardiovascular health and disease

Cited by 2 publications

References 67 publications

The effect of aged garlic extract on the atherosclerotic process – a randomized double-blind placebo-controlled trial

The effect of aged garlic extract on the atherosclerotic process – a randomized double-blind placebo-controlled trial

Science dialogue mapping of knowledge and knowledge gaps related to the effects of dairy intake on human cardiovascular health and disease

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