Scintigraphic Evaluation of Early Osteoblastic Activity in Extraction Sockets Treated With Platelet-Rich Plasma

Clinical Evaluation of Use of Platelet Rich Plasma in Bone Healing

“…Variations in platelet concentration are known to influence bone healing [8]. Study conducted by Bahadir Gürbüzer et al [14] showed that healing of extraction sockets treated with PRP alone had failed to show improved healing which was evaluated by bone scintigraphy method. Similar result was noted in some of our cases evaluated with digital OPG (Fig 9).…”

“…Some investigators have reported significant improvements in tissue healing and bone formation using PRP [1,4,7,8,11,12,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] whereas others did not observe improvements [2,5,13,14,[32][33][34][35][36]. Some have given no conclusion regarding effect of PRP application in maxillofacial region than periodontal defects [37].…”

“…There are studies that used different materials for activation of platelets before insertion of PRP in surgical defect. Some have used 10 % CaCl 2 alone [2,12,14,15,18,25,29] as we have used. Anitua was the first who began the trend of using only CaCl 2 .…”

“…One study had used calcium gluconate [13] with satisfactory result. Some had used 10 % CaCl 2 and bovine thrombin [3,10,14,20,21,31,32,34,38] at the same sitting some have used thrombin alone [35,37]. Landesberg et al [2] opposed the use of bovine thrombin, considering the risk of developing antibodies that cross react with factors V, XI and thrombin and induce coagulopathies.…”

“…Because the life span of a platelet in a wound and direct influence of its growth factors is \ 5 days (range 5-8 days) a pronounced effect of PRP would be expected to occur especially in the early stage of bone healing [14,32]. Study conducted by David Gerard et al reported that healing of mandibular defect treated with autologous bone graft with PRP in dogs results in early (1 and 2 months) beneficial effects, but 3 and 6 months time period did not have any added beneficial effect [10].…”