Sclareol isolated from <i>Salvia officinalis</i> improves facial wrinkles via an antiphotoaging mechanism

Park, Ji‐Eun; Kyung-Eun, Lee; Jung, Eunsun; Kang, Seunghyun; Kim, Youn Joon

doi:10.1111/jocd.12239

Cited by 13 publications

(7 citation statements)

References 19 publications

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“…Sclareol is an isoprenoid isolated from common sage ( Salvia officinalis) which is widely used as natural fragrance. This natural compound exhibits diverse biological properties such as antioxidative, anti-fungal, anticancer, antimicrobial, anti-inflammatory, and anticholinesterase activities (Park et al 2016 ). Park and colleagues (2016) used human dermal fibroblasts and reconstructed human skin to investigate the efficacy of sclareol to prevent the damage caused by UVB irradiation and conducted a clinical study to identify its ability to ameliorate the signs of photoaging of human skin (Park et al 2016 ).…”

Section: Natural Compounds Used Against Photoagingmentioning

confidence: 99%

“…This natural compound exhibits diverse biological properties such as antioxidative, anti-fungal, anticancer, antimicrobial, anti-inflammatory, and anticholinesterase activities (Park et al 2016 ). Park and colleagues (2016) used human dermal fibroblasts and reconstructed human skin to investigate the efficacy of sclareol to prevent the damage caused by UVB irradiation and conducted a clinical study to identify its ability to ameliorate the signs of photoaging of human skin (Park et al 2016 ). In this study they observed that sclareol is able to recover the proliferative capacity of Hs68 cells treated with UVB while it inhibits the UVB-induced expression of MMPs via regulation of AP-1 constituents (Park et al 2016 ).…”

Section: Natural Compounds Used Against Photoagingmentioning

confidence: 99%

“…Park and colleagues (2016) used human dermal fibroblasts and reconstructed human skin to investigate the efficacy of sclareol to prevent the damage caused by UVB irradiation and conducted a clinical study to identify its ability to ameliorate the signs of photoaging of human skin (Park et al 2016 ). In this study they observed that sclareol is able to recover the proliferative capacity of Hs68 cells treated with UVB while it inhibits the UVB-induced expression of MMPs via regulation of AP-1 constituents (Park et al 2016 ). Reconstructed human skin models exposed to 3 UVB irradiations and subsequently treated with two different concentrations of sclareol (1 and 10 µM) exhibited decreased epidermal thickness and recovery of cellular proliferative capacity in comparison to UVB-irradiated 3D models that were not treated with the compound.…”

Section: Natural Compounds Used Against Photoagingmentioning

confidence: 99%

“…In addition, in a clinical trial, the study investigated the effect of a cosmetic formulation containing 0.02% sclareol on facial wrinkle appearance was investigated. After 12 weeks of treatment, total wrinkle area, percentage of wrinkle area, and total wrinkle length were significantly reduced in the test group compared to the control group suggesting that sclareol may be an effective cosmetic ingredient to help reducing the effects of UVB-induced photoaging (Park et al 2016 ).…”

Section: Natural Compounds Used Against Photoagingmentioning

confidence: 99%

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Plant extracts and natural compounds used against UVB-induced photoaging

et al. 2017

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Skin is continuously exposed to a variety of environmental stresses, including ultraviolet (UV) radiation. UVB is an inherent component of sunlight that crosses the epidermis and reaches the upper dermis, leading to increased oxidative stress, activation of inflammatory response and accumulation of DNA damage among other effects. The increase in UVB radiation on earth due to the destruction of stratospheric ozone poses a major environmental threat to the skin, increasing the risk of damage with long-term consequences, such as photoaging and photocarcinogenesis. Extracts from plants and natural compounds have been historically used in traditional medicine in the form of teas and ointments but the effect of most of these compounds has yet to be verified. Regarding the increasing concern of the population with issues related to quality of life and appearance, the cosmetic market for anti-aging and photoprotective products based on natural compounds is continuously growing, and there is increasing requirement of expansion on research in this field. In this review we summarized the most current and relevant information concerning plant extracts and natural compounds that are able to protect or mitigate the deleterious effects caused by photoaging in different experimental models.

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Section: Natural Compounds Used Against Photoagingmentioning

confidence: 99%

Section: Natural Compounds Used Against Photoagingmentioning

confidence: 99%

Section: Natural Compounds Used Against Photoagingmentioning

confidence: 99%

Section: Natural Compounds Used Against Photoagingmentioning

confidence: 99%

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Plant extracts and natural compounds used against UVB-induced photoaging

et al. 2017

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“…SCL performed antiphotoaging efficacy in vitro, and exhibited wrinkle improvement effect in clinical test (0.02% sclareol-containing cream). Furthermore, SCL inhibited ultraviolet-B inducing MMPs expression and prevented collagen degradation by down-regulating the protein expression of AP-1 transcription factors ( Park et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

The bioactivities of sclareol: A mini review

Zhou

Xie²,

Tang³

et al. 2022

Front. Pharmacol.

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Sclareol, a diterpene alcohol isolated from the herbal and flavor plant clary sage (Salvia sclarea L.), is far-famed as the predominant ingredient in the refined oil of Salvia sclarea (L.). The empirical medicine of Salvia sclarea L. focused on various diseases, such as arthritis, oral inflammation, digestive system diseases, whereas the sclareol possessed more extensive and characteristic bioactivities, including anti-tumor, anti-inflammation and anti-pathogenic microbes, even anti-diabetes and hypertension. However, there is a deficiency of literature to integrate and illuminate the pharmacological attributes of sclareol based on well-documented investigations. Interestingly, sclareol has been recently considered as the potential candidate against COVID-19 and Parkinson’s disease. Accordingly, the bioactive attributes of sclareol in cancer, inflammation, even pharmacochemistry and delivery systems are reviewed for comprehensively dissecting its potential application in medicine.

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