Scleredema and Diabetes Mellitus

Fleischmajer, Raúl; Faludi, Georgina; Krol, Stefan

doi:10.1001/archderm.1970.04000010023003

Cited by 69 publications

(23 citation statements)

References 7 publications

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“…Histologically a hyperplasia of collagen fibers and an increase in collagen and glycosaminoglycans have also been found [13,14] In scleroderma-like lesions of IDDM Hama et al [8] described active fibroblasts and extensive collagen polymerization in the rough endopliismic reticulum of diabetic thick skin. Glucose excess seems to play an important role in diabetic skin.…”

Section: Discussionmentioning

confidence: 99%

Scleroderma‐like lesions in insulin‐dependent diabetes mellitus

Haustein

1999

Acad Dermatol Venereol

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We report on two patients (one female 42 years, one male 47 years) suffering from insulin-dependent diabetes mellitus (IDDM) for more than 20 years. Both patients exhibited sclerodactyly and sclerosis of the hands and lower arms as well as swelling and slight contracture of the distal interphalangeal joints. Interestingly, internal organs were not involved and autoantibodies characteristic for scleroderma were missing. Poor utilization and excess of glucose seem to be responsible for the activation of fibroblasts to produce abundant matrix proteins in the skin. Significant therapeutic improvement of the glucose metabolism was able to improve joint contractures or at least to stop the progression of skin changes in our patients. These skin changes should not be misdiagnosed as systemic sclerosis.

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Section: Discussionmentioning

confidence: 99%

Scleroderma‐like lesions in insulin‐dependent diabetes mellitus

Haustein

1999

Acad Dermatol Venereol

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“…Accepted for publication April 6,1971. From the departments of medicine (Dr. Fleishmajer) and pathology ( -Left, Dermis revealing compact, thick collagen bundles, poor cellularity, and a preserved eccrine sweat gland (ESG).…”

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confidence: 99%

Alteration of Subcutaneous Tissue in Systemic Scleroderma

Fleischmajer¹

1972

Arch Dermatol

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130

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“…In the case of SA the pathologic hallmark is a markedly thickened dermis with prominent large spaces between collagen bundles and variable deposition of mucin in these areas. 8 Although SA classically affects the skin, extracutaneous involvement of heart, lungs, muscles, esophagus, and eyes with restricted motility and sicca syndrome have also been reported. 9,10 SA commonly resolves spontaneously within 6 months to 2 years.…”

Section: Discussionmentioning

confidence: 99%