Sclérodermie systémique chez l’homme

Gaultier, J.-B.; Hot, A.; Cathébras, P.; Grangé, C.; Ninet, J.; Rousset, H.

doi:10.1016/j.revmed.2007.07.010

Cited by 17 publications

(11 citation statements)

References 23 publications

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“…Conversely, 2 studies from Spain comparing male and female SSc patients found no gender differences by disease type [15], [18]. Finally, from a recent retrospective French survey of 121 SSc patients, dcSSc was more frequent in males than in females (22% vs 5%) [42]. In these last 3 studies, the male sample sizes were rather small (n = 9, n = 26 and n = 36, respectively).…”

Section: Discussionmentioning

confidence: 97%

“…Lung involvement is common in the course of SSc, and together, ILD and pulmonary hypertension are considered the 2 main causes of death in this disease [48]. ILD is more frequent in male SSc patients at the time of diagnosis and during follow-up [42]. In addition, male gender is associated with pulmonary hypertension during follow-up [42].…”

Section: Discussionmentioning

confidence: 99%

“…ILD is more frequent in male SSc patients at the time of diagnosis and during follow-up [42]. In addition, male gender is associated with pulmonary hypertension during follow-up [42]. In 1180 SSc patients (19% men) studied at early stages of the disease, men more often than women were found to have lung fibrosis and lower diffusing lung capacity for carbon monoxide than women [19].…”

Section: Discussionmentioning

confidence: 99%

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Association of Gender with Clinical Expression, Quality of Life, Disability, and Depression and Anxiety in Patients with Systemic Sclerosis

Nguyen¹,

Bérezné²,

Baubet³

et al. 2011

PLoS ONE

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ObjectivesTo assess the association of gender with clinical expression, health-related quality of life (HRQoL), disability, and self-reported symptoms of depression and anxiety in patients with systemic sclerosis (SSc).MethodsSSc patients fulfilling the American College of Rheumatology and/or the Leroy and Medsger criteria were assessed for clinical symptoms, disability, HRQoL, self-reported symptoms of depression and anxiety by specific measurement scales.ResultsOverall, 381 SSc patients (62 males) were included. Mean age and disease duration at the time of evaluation were 55.9 (13.3) and 9.5 (7.8) years, respectively. One-hundred-and-forty-nine (40.4%) patients had diffuse cutaneous SSc (dcSSc). On bivariate analysis, differences were observed between males and females for clinical symptoms and self-reported symptoms of depression and anxiety, however without reaching statistical significance. Indeed, a trend was found for higher body mass index (BMI) (25.0 [4.1] vs 23.0 [4.5], p = 0.013), more frequent dcSSc, echocardiography systolic pulmonary artery pressure >35 mmHg and interstitial lung disease in males than females (54.8% vs 37.2%, p = 0.010; 24.2% vs 10.5%, p = 0.003; and 54.8% vs 41.2%, p = 0.048, respectively), whereas calcinosis and self-reported anxiety symptoms tended to be more frequent in females than males (36.0% vs 21.4%, p = 0.036, and 62.3% vs 43.5%, p = 0.006, respectively). On multivariate analysis, BMI, echocardiography PAP>35 mmHg, and anxiety were the variables most closely associated with gender.ConclusionsIn SSc patients, male gender tends to be associated with diffuse disease and female gender with calcinosis and self-reported symptoms of anxiety. Disease-associated disability and HRQoL were similar in both groups.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association of Gender with Clinical Expression, Quality of Life, Disability, and Depression and Anxiety in Patients with Systemic Sclerosis

Nguyen¹,

Bérezné²,

Baubet³

et al. 2011

PLoS ONE

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“…The literature data demonstrated that the time to diagnosis was significantly longer in women [ 3 , 24 ]. Hudson et al studied 408 patients with SSc and found that the time to diagnosis was significantly longer for women compared to men when the disease onset was measured from the onset of Raynaud's phenomenon; otherwise, when measured from the onset of the first non-Raynaud's disease manifestation, the time to diagnosis was not significantly different [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…The disease is more severely expressed in men than in women. This finding could be associated with the dc subtype of the disorder, which is more frequent in men compared to women, severe organ involvement, particularly higher incidence of SRC, vasculopathy and cardiac involvement [ 5 , 12 , 13 , 24 , 26 , 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of clinical and serological parameters in female and male patients with systemic sclerosis

et al. 2016

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ObjectivesThe course of systemic sclerosis (SSc) can differ in female and male patients. According to the literature the incidence rates of diffuse cutaneous SSc, scleroderma renal crisis and digital ulceration are higher in male patients. The aim of the study was to compare selected clinical and serological parameters in male and female patients with SSc.Material and methodsThe study encompassed 101 European Caucasian patients with SSc, including 23 men, hospitalized in the Department of Rheumatology. Patients fulfilled the American Rheumatism Association (ARA) classification criteria for SSc. The study groups of men and women were assessed according to the SSc subtype, incidence of internal organ involvement and presence of antinuclear antibodies considered SSc markers.ResultsDiffuse cutaneous (dc) SSc was observed more commonly in men than in women (13/23 vs. 25/78; p = 0.03). The time from the development of Raynaud's phenomenon to the diagnosis was significantly shorter in male compared to female patients (3.2 ±4.7 vs. 7.5 ±7.1; p = 0.01). The incidence of scleroderma renal crisis (SRC) was significantly higher (3/23 vs. 2/78; p = 0.04) and of other calcifications significantly lower in the male group compared to the female group (1/23 vs. 20/78; p = 0.02).ConclusionsWe concluded that the incidence of dcSSc is higher in men compared to women. The time from the development of Raynaud's phenomenon to the diagnosis is shorter in the male compare to female group. The incidence of SRC is higher, whereas that of calcifications is lower in SSc men. The serological profiles of female and male patients with SSc are comparable.

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Comparison of clinical presentation and incidence of cardiopulmonary complications between male and female Thai patients with early systemic sclerosis: inception cohort study

et al. 2019

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Sclérodermie systémique chez l’homme

Cited by 17 publications

References 23 publications

Association of Gender with Clinical Expression, Quality of Life, Disability, and Depression and Anxiety in Patients with Systemic Sclerosis

Association of Gender with Clinical Expression, Quality of Life, Disability, and Depression and Anxiety in Patients with Systemic Sclerosis

Comparison of clinical and serological parameters in female and male patients with systemic sclerosis

Comparison of clinical presentation and incidence of cardiopulmonary complications between male and female Thai patients with early systemic sclerosis: inception cohort study

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