Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: a case report and review of the literature

Shehadeh, N. J.; Vernick, John P; Lonardo, Fulvio; Madan, Shashi; Jacobs, John R.; Yoo, George H.; Kim, Harold E.; Ensley, John F.

doi:10.1016/s0196-0709(03)00096-6

Cited by 47 publications

(37 citation statements)

References 12 publications

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“…Microscopically, thyroid SMECE is characterized by a combination of nested epidermoid carcinoma cells, intermediate carcinoma cells, and mucous-secreting carcinoma cells, fibrohyaline stroma, and prominent eosinophilic and lymphoplasmacytic infiltrates [10][11][12][13][14][15][16][17][18][19]. All of our cases showed these features.…”

Section: Discussionmentioning

confidence: 82%

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Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia distinct from the salivary type

et al. 2018

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Abstract. We report three cases of thyroid sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE), which is an extremely rare variant of mucoepidermoid carcinoma (MEC). The aims of this report were to describe the clinicopathological findings, including results from immunohistochemical and fluorescence in situ hybridization analysis of thyroid SMECE, as well as to discuss the distinction between thyroid SMECE and its salivary counterpart. The cases included a 63-year-old female, a 44-year-old male, and a 66-year-old female, with all patients presenting with Hashimoto's thyroiditis. Nodal metastasis was not found in any of the three cases. Neither regional recurrences nor distant metastases were found in any patient during the follow-up, which was 20 years, 3 years, and 18 months, respectively. Histologically, tumors were composed of epidermoid carcinoma cells, intermediate type carcinoma cells, and goblet cell-type mucus-secreting carcinoma cells, with all tumors displaying a sclerotic stroma with eosinophilic and lymphocytic infiltration. The formation of eosinophilic abscess in the tumor nests that might be a novel characteristic finding of SMECE was observed. Immunohistochemically, the carcinoma cells were positive for cytokeratin 34βE12, TTF-1, and PAX8, but negative for thyroglobulin. In two cases, increased IgG4-positive plasma cells were observed. Mastermind-like transcriptional coactivator 2 (MAML2), according to fluorescence in situ hybridization, was intact in all cases. In conclusion, thyroid SMECE has favorable outcomes and seems to be genetically different from salivary MEC. This is the first report to describe the presence of increased IgG4-positive plasma cells in the stroma of SMECE. [16]. The prognosis of this malignancy is favorable, although nodal metastases, extrathyroidal invasion, vascular invasion, and perineural invasion are common [12]. We encountered three patients with this rare sclerotic variant of MEC. The aims of this report were to describe the clinicopathological findings, including results from immunohistochemical and fluorescence in situ hybridization (FISH) analysis of thyroid SMECE, as well as to discuss the distinction between thyroid SMECE and its salivary counterpart.

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Section: Discussionmentioning

confidence: 82%

“…Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is an extremely rare variant of MEC that displays a sclerotic stroma with eosinophilic and lymphocytic infiltration [9]. Interestingly, we more frequently encountered cases with a sclerotic variant in the thyroid, in the literature [10][11][12][13][14][15][16][17][18][19].…”

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confidence: 99%

Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia distinct from the salivary type

et al. 2018

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“…Various histologic subtypes have been seen in axillary nodal metastasis including papillary thyroid carcinoma [4][5][6][7][8][9], sclerosing mucoepidermoid carcinoma with eosinophilia [10], mucin producing poorly differentiated adenocarcinoma [11] and primary mucoepidermoid carcinoma [12]. Few hypotheses have been proposed to explain the unusual spread.…”

Section: Case Reportmentioning

confidence: 99%

Radioiodine Avid Axillary Lymph Node Metastasis in Papillary Thyroid Cancer: Report of a Case

Damle

Singh

Soundararajan

et al. 2011

Indian J Surg Oncol

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“…This was duplicated The most common presenting symptom is a painless neck mass or cold nodule on thyroid scan. 19) Symptoms secondary to locoregional extension such as hoarseness have been described. The average age of patients in the literature was 54 years with the majority of the patients being women.…”

Section: Introductionmentioning

confidence: 99%

“…The average age of patients in the literature was 54 years with the majority of the patients being women. 19) The first man to be reported with SMECE was in a case series of 3 patients reported by Wenig et al 14) in which the patient was unfortunately lost to follow-up after having surgery. The second male patient reported by Geisinger et al 3) had spine and liver metastasis.…”

Section: Introductionmentioning

confidence: 99%

Primary Sclerosing Mucoepidermoid Carcinoma with Eosinophilia of the Thyroid: Description of a Case and Review of the Literature

2017

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Primary sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) of the thyroid gland is a very rare disease. We present the clinical and histopathologic findings of a 37-year-old woman recently diagnosed with SMECE of the thyroid gland. The patient, clinically euthyroid, who presented with a neck swelling since last 2 years along. Fine needle aspiration cytology suggested thyroid papillary carcinoma. Total thyroidectomy, central neck dissection and right selective neck dissection were performed. Although SMECE is considered to be a relatively slow growing and non-aggressive tumor, occasional metastasis does occur. We report an additional case of SMECE, with metastasis to regional lymph nodes. Physicians should be aware of extended operation, including total thyroidectomy and/or neck node dissection for metastatic lesion of the neck node. More standardized treatment is likely to evolve in the future.

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Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: a case report and review of the literature

Cited by 47 publications

References 12 publications

Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia distinct from the salivary type

Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia distinct from the salivary type

Radioiodine Avid Axillary Lymph Node Metastasis in Papillary Thyroid Cancer: Report of a Case

Primary Sclerosing Mucoepidermoid Carcinoma with Eosinophilia of the Thyroid: Description of a Case and Review of the Literature

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