Sclerosing Pneumocytoma of the  Lung: A Case Report

Arumugam, Vasugi Gramani; Joseph, Leena Dennis; Thangavel, Periyasamy; Swaminathan, Rajaraman; Sunderaj, Ramya Rathinam

doi:10.7860/jcdr/2017/22279.9271

Cited by 10 publications

(15 citation statements)

References 10 publications

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“…Although PSP is often solitary, well-defined, round or oval, homogeneous nodule or mass, there is no definitive diagnostic radiographic finding [7]. However, there are also cases of metastases to the lymph nodes, pleura, and bones [[8], [9], [10]]. Patients may present with a mass lesion of up to 7 cm through 73% of the lesions are below 3 cm [2,4].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary sclerosing pneumocytoma, a rare tumor of the lung

Yalçın¹,

Bekçi²,

Kozacıoğlu³

et al. 2019

Respiratory Medicine Case Reports

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Pulmonary sclerosing pneumocytoma (PSP) is a rare benign pulmonary tumor. Usually diagnosed incidentally by chest X-ray or chest CT scan. We presented a case of PSP in a 50-year-old woman who was diagnosed with a nodular lesion in the right lung. Thoracotomy was used for the excision of the mass. Pathologic examination revealed no malignant cells. Immunohistochemical studies were performed. TTF-1 was (+), Napsin-A was found to be weakly (+). After surgical resection, the patient was followed up.

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Section: Discussionmentioning

confidence: 99%

Pulmonary sclerosing pneumocytoma, a rare tumor of the lung

Yalçın¹,

Bekçi²,

Kozacıoğlu³

et al. 2019

Respiratory Medicine Case Reports

View full text Add to dashboard Cite

show abstract

“…These two immunohistochemical markers are epithelial markers and support why it is postulated that the tumor is derived from a primitive respiratory epithelium rather than from a vascular origin. 4,16 Endobronchial ultrasound with transbronchial needle aspiration is often used in the diagnosis and staging of lung cancer by analyzing small fragments. As this case illustrates, however, it only rarely provides ample material for the necessary immunohistochemistry to diagnose a pulmonary pneumocytoma.…”

Section: Pathologic Discussionmentioning

confidence: 99%

A 58-Year-Old Woman With Back Pain and an Unusual Diagnosis

Bohm

Asiry

Hasanovic

et al. 2019

Chest

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A 58-year-old postmenopausal woman presented to her primary care physician with lower back pain. She denied respiratory symptoms. Her medical history is significant for hypertension, hyperlipidemia, and prediabetes. Her surgical history consists of a tonsillectomy and a remote dilatation and curettage procedure. She denied a history of smoking, alcohol use, or recreational drug use. A review of systems was otherwise negative.

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“…Occasionally, PSP may manifest as multiple lesions, recurrence, regional lymph nodes (LNs), or single organ metastasis, but is not likely to affect the prognosis. Therefore, PSP is considered as a benign or a low-grade malignant potential primary lung tumor (3)(4)(5)(6)(7)(8). Herein, we report an extremely rare PSP case with atypical histological features, rapid recurrence and multiply metastases, and try to elucidate the molecular mechanism of the malignant progression through clinic pathological, Immunohistochemistry (IHC), and wholeexome sequencing (WES) data.…”

Section: Introductionmentioning

confidence: 99%

Case Report and Literature Review: Pulmonary Sclerosing Pneumocytoma With Multiple Metastases Harboring AKT1 E17K Somatic Mutation and TP53 C176Y Germline Mutation

Wang

Jiang

et al. 2021

Front. Med.

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Pulmonary Sclerosing Pneumocytoma (PSP) is considered as a benign tumor, although a few cases have been reported to have multiple lesions, recurrence, and even regional lymph nodes (LNs) metastasis. Here, we report a case of PSP with atypical histologic features and malignant biological behavior, and explore its molecular genetic changes. The 23-year-old male showed a 6.5-cm pulmonary nodule in the right middle lobe (RML) and enlarged media stinal LNs. He underwent thoracoscopic RML lobectomy, systematic LNs dissection, and mediastinal lymphadenectomy. The metastases to the cervical LNs and liver were detected in a short period and then resected. Postoperative pathological examination confirmed the diagnosis of PSP in all the lesions, based on the histological characteristics and immune phenotypes. Furthermore, whole-exome sequencing identified both AKT1 E17K somatic mutation and TP53 C176Y germline mutation in this case. Thus, we presented an extremely rare case of atypical PSP with rapid recurrence and multiply metastases, which can easily be misdiagnosed as primary lung cancer. In addition, PSP-specific AKT1 E17K somatic E17K somatic mutation accompanied with TP53 C176Y germline mutation may contribute to the malignant clinical course of this tumor.

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Sclerosing Pneumocytoma of the Lung: A Case Report

Cited by 10 publications

References 10 publications

Pulmonary sclerosing pneumocytoma, a rare tumor of the lung

Pulmonary sclerosing pneumocytoma, a rare tumor of the lung

A 58-Year-Old Woman With Back Pain and an Unusual Diagnosis

Case Report and Literature Review: Pulmonary Sclerosing Pneumocytoma With Multiple Metastases Harboring AKT1 E17K Somatic Mutation and TP53 C176Y Germline Mutation

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