Sclerosing polycystic adenosis of parotid gland with dysplasia and ductal carcinoma in situ

Skálová, Alena; Michal, Michael; Simpson, Roderick H.W.; Stárek, Ivo; Přádná, J.; Pfaltz, Madeleine

doi:10.1007/s004280100481

Cited by 74 publications

(57 citation statements)

References 18 publications

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“…On the other hand, other studies have demonstrated a monoclonal origin for this lesion, thus corroborating a possible neoplastic origin 2,12) . In addition, because it resembles a fibrocystic lesion, breast adenosis, and different degrees of dysplasia, some authors consider SPA to be a low-grade malignant neoplasm 13) .…”

Section: Discussionmentioning

confidence: 99%

“…It may also present ductal epithelial hyperplasia and atypia that may range from mild to severe dysplasia/carcinoma in situ 1,5) . An important characteristic of these lesions occurs due to the presence of acini filled with dispersed zymogen and reddish granules 13) . Immunohistochemistry may be positive for cytokeratin, epithelial membrane antigen, S100 proteins, cystic disease protein fluid, or smooth muscle alpha cells.…”

Section: Discussionmentioning

confidence: 99%

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Sclerosing Polycystic Adenosis of Tongue

Braz‐Silva

Canto

Oliveira

et al. 2018

Bull. Tokyo Dent. Coll.

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Sclerosing polycystic adenosis (SPA) is a rare benign lesion of the salivary glands which appears histologically similar to sclerosing adenosis and fibrocystic disease of the mammary gland. To date, 67 cases of SPA have been reported in the literature, with the lesion arising in the minor salivary glands in only 9. The present report describes the 10th case of SPA. The patient was a 39-year-old Brazilian man who presented with an asymptomatic nodule on the ventral surface of the tongue. Based on a clinical diagnosis of benign salivary gland neoplasm, an excisional biopsy of the lesion was performed. Histopathological examination showed lobular proliferation of ductal and acinar elements surrounded by a fibrosclerotic stroma. Many of the ductal structures exhibited cystic dilatation and were surrounded by periductal fibrosis, which is consistent with SPA findings. No recurrence of the disease was observed after a 5-year follow-up. A literature review is also discussed, focusing on both the etiology of SPA and the treatment options available.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sclerosing Polycystic Adenosis of Tongue

Braz‐Silva

Canto

Oliveira

et al. 2018

Bull. Tokyo Dent. Coll.

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“…Coarse, strongly eosinophilic cytoplasmic granules are often found within acinar structures [1,2]. The features of SPA are similar to fibrocystic changes of the breast and some evidence suggests that cells within SPA exhibit estrogen and progesterone receptor activity [9].…”

Section: Diagnosismentioning

confidence: 90%

“…There are ectatic ducts and cysts with apocrine-like metaplasia and epithelial hyperplasia that may exhibit cribriform growth [1,8]. Atypia may be found within the ductal epithelium to a degree that warrants the diagnosis of dysplasia [9]. Occasional hyaline globules reminiscent of collagenous spherulosis may be present.…”

Section: Diagnosismentioning

confidence: 99%

Sclerosing Polycystic Adenosis

Eliot

Smith

Foss

2011

Head and Neck Pathol

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A 25-year-old female presented with a welldefined, painless mass of 1 year's duration in the right parotid gland. MR imaging revealed a relatively well-circumscribed lesion involving the deep and superficial lobes of the right parotid gland. Histologic examination of the resection resulted in a diagnosis of sclerosing polycystic adenosis, a rare benign salivary gland entity of presumed non-neoplastic origin. The clinical, radiographic, and morphologic features of sclerosing polycystic adenosis are discussed.

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“…SPA was first described by Smith et al in 1996 in a series of 9 cases [1]. Since then just over 50 cases in a few larger series and several case reports have been published [2][3][4][5][6][7][8][9][10][11][12][13][14]. The most common site is the parotid gland with less frequent occurrence in the submandibular gland and intraoral minor salivary glands.…”

Section: Introductionmentioning

confidence: 99%

Sclerosing Polycystic Adenosis of the Parotid Gland: Report of a Bifocal, Paucicystic Variant with Ductal Carcinoma in situ and Pronounced Stromal Distortion Mimicking Invasive Carcinoma

Petersson

Tan

Hwang

2011

Head and Neck Pathol

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We present a case (female patient, age 45 years) with a bifocal, paucicystic variant of sclerosing polycystic adenosis of the parotid gland with cribriform ductal carcinoma in situ (DCIS) and pronounced stromal distortion affecting the in situ component to such an extent that it gave a distinct impression of intralesional invasive adenocarcinoma. P63-and calponin-positive myoepithelial cells were present in the periphery of the acini and ducts in the benign component, somewhat discontinuously in the DCIS-component, and even in the periphery of the small irregular atypical cell nests that appeared infiltrative on the haematoxylin and eosin stained sections. Strong cytoplasmic immunoreactivity for GCDFP-15 was detected in the benign component with a variable, patchy and mostly weak positivity in the DCIS. More than 90% of the cells in the DCIS component displayed strong nuclear immunoreactivity for androgen receptors and 10% of the benign ducts showed positivity. Weak to moderate nuclear immunoreactivity for estrogen receptors was seen in 30% of cells in the benign ductal component whereas the DCIS was negative. Occasional cells in the adenosis-component were weakly positive for PR. The proliferative activity (Mib-1/Ki-67) was low (1-2%) in the benign component whereas increased proliferation was seen in the DCIS and in the areas with pseudoinfiltration which also featured atypical mitoses.

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Sclerosing polycystic adenosis of parotid gland with dysplasia and ductal carcinoma in situ

Cited by 74 publications

References 18 publications

Sclerosing Polycystic Adenosis of Tongue

Sclerosing Polycystic Adenosis of Tongue

Sclerosing Polycystic Adenosis

Sclerosing Polycystic Adenosis of the Parotid Gland: Report of a Bifocal, Paucicystic Variant with Ductal Carcinoma in situ and Pronounced Stromal Distortion Mimicking Invasive Carcinoma

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