Sclerosing therapy with bleomycin emulsion for lymphangioma in children

Tanaka, Kōichi; Inomata, Yukihiro; Utsunomiya, Hirofumi; Üemoto, Shinji; Asonuma, Katsuhiro; Katayama, Tetsuo; Ozawa, Kazue; Hashida, Mitsuru

doi:10.1007/bf00169668

Cited by 37 publications

(36 citation statements)

References 3 publications

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“…Intralesional Bleomycin microsphere in oil-emulsion has reported good response because it is retained for longer period of time. 17, " Report of intralesional aqueous solution of Bleomycin is limited 16,19 In our study, intralesional aqueous solution of Bleomycin has good response in cystic type of lymphangioma as compared to cavernous and other complex lymphangioma 19 . One patient showed complete disappearance after single dose of Bleomycin.…”

Section: Discussionmentioning

confidence: 57%

Non surgical management of cystic lymphangioma

Rawat

Sinha

Kanojia

et al. 2006

Indian J Otolaryngol Head Neck Surg

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Section: Discussionmentioning

confidence: 57%

Non surgical management of cystic lymphangioma

Rawat

Sinha

Kanojia

et al. 2006

Indian J Otolaryngol Head Neck Surg

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“…3 The lesion occurs with approximately equal frequency in boys and girls. 4 The cause likely is related to events that occur during the development of the lymphatic system in which the primitive lymphatic sac fail to establish communication with developing venous system. Hygromas usually reside in close proximity to large veins and lymphatic ducts, in neck (75%), axilla (20%) and others (5%) e.g.…”

Section: Introductionmentioning

confidence: 99%

Effect of intralesional bleomycin as an alternative therapy for cystic hygroma

Saha

Haque

Islam

2014

Bangladesh med. j. Khulna

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“…Recently, bleomycin and OK-432 sclerosing therapy have been used successfully to treat lymphangiomas in children. 8,9 In mediastinal lymphangioma, parts of the tumor may be insinuated between or adherent to neighboring vital structures, which makes complete excision hazardous, as in our patient. We agree with other authorities who recommend deroofing of the cysts with resection of the maximum amount of cyst wall in these patients rather than risking injury to vital structures.…”

Section: Discussionmentioning

confidence: 80%

Giant Mediastinal Cystic Hygroma in a Child

et al. 1997

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Lymphangioma is a benign and common disorder in the pediatric age group. Cervical cystic hygroma was first described clinically in 1828 by Redenbacker and pathologically in 1843 by Wernher.1 They are frequently seen in the neck (75%) and axilla (20%).2 Most mediastinal cystic hygromas are extensions of cervical lesions, and cystic hygroma confined solely to the mediastinum is rarely encountered. 3,4 We report a case of a female child with a purely extensive mediastinal cystic hygroma, outlining aspects of its unusual clinical features and management. Case ReportA three-year-old female was referred to our hospital because of chest pain and bulging of the right side of the chest of two weeks' duration. The parents gave a history of weight loss, but there was no fever. On examination, she was found to be pale, but not jaundiced or cyanotic. The right side of the chest was found to bulge, in comparison with the left. There was decreased air entry on the right side of the chest, with dullness on percussion. Chest x-ray revealed a right-sided pleural effusion. Thoracentesis yielded serosanguinous fluid, which contained gelatinous material. Biochemical and cytological analysis of the fluid gave the following results: glucose 90 mg/dL, total protein 4.6 g/dL, LDH 115 U/L and 8200 WBC U/L, predominantly lymphocytes and many RBCs. Cytology of the aspirated fluid revealed no malignant cells. Bacterial, fungal and mycobacterial cultures showed no growth. PPD was negative.A right-sided thoracostomy tube was inserted and postdrainage chest x-ray ( Figure 1) revealed a large rightsided mass. HCG was normal and serum BHCG was <5. Ultrasonography of the chest could not be done because of the lack of a proper transducer. CT scan of chest (Figure 2) showed a large right-sided lobulated mass occupying the entire anterior mediastinum. The left margins of the mass were inseparable from the pericardial surface of the heart, which was displaced to the left. The chest was opened via a right anterolateral thoracotomy through the bed of the 5th rib. There was a large tumor which was fixed and infiltrating into the anterior chest wall. The posterior part of the tumor was firm, but the anterior part was friable and soft. There was a possibility of teratoma or lymphoma, and a large biopsy was taken. Histology revealed a vascular tumor made up of various sizes of vascular channels lined by endothelium (Figure 3). The stroma was edematous and myxoid, containing spindle and stellate cells with mild nuclear pleomorphism and no mitosis (Figure 4). The stroma contained a diffuse infiltrate of lymphonuclear cells and neutrophils. A fibrous capsule was seen with a few thick fibrous septa. The diagnosis of cystic lymphangioma was made. The patient continued to be symptomatic and so the chest was re-explored and near complete excision of the mass was done, leaving only small fragments that were densely adherent to the hilum of the lung. The cysts near the hilum of the lung and adherent to the pulmonary vessels were deroofed and as much of the capsule ...

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Sclerosing therapy with bleomycin emulsion for lymphangioma in children

Cited by 37 publications

References 3 publications

Non surgical management of cystic lymphangioma

Non surgical management of cystic lymphangioma

Effect of intralesional bleomycin as an alternative therapy for cystic hygroma

Giant Mediastinal Cystic Hygroma in a Child

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