2016
DOI: 10.1002/jbmr.2988
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Sclerostin Blockade—A Dual Mode of Action After All?

Abstract: IntroductionG lucocorticoids (GCs) are frequently used to treat inflammatory diseases. However, GC excess, either due to long-term GC therapy or endogenous overproduction, often causes rapid bone loss. GC-induced osteoporosis (GIO) is the most common form of secondary osteoporosis with a predominant risk of vertebral fractures. Oral administration of as little as 2.5 mg prednisolone per day for more than 3 months already leads to a 1.5-fold increase in fracture risk, whereas the relative risk rises up to fivef… Show more

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Cited by 6 publications
(2 citation statements)
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“…Likely, a transient effect on osteoclasts may be envisaged, similar to the suppression of osteoclast activity by sclerostin, which likewise remains to be conclusively addressed. (32) Overall, the bone phenotype of Dkk1 fl/fl ;Osx-Cre mice strongly resembles that of Dkk1 fl/fl ;Dmp1-Cre mice. Importantly, one major difference between the mouse lines was the reduction of systemic Dkk1 levels.…”
Section: Journal Of Bone and Mineral Researchmentioning
confidence: 85%
See 1 more Smart Citation
“…Likely, a transient effect on osteoclasts may be envisaged, similar to the suppression of osteoclast activity by sclerostin, which likewise remains to be conclusively addressed. (32) Overall, the bone phenotype of Dkk1 fl/fl ;Osx-Cre mice strongly resembles that of Dkk1 fl/fl ;Dmp1-Cre mice. Importantly, one major difference between the mouse lines was the reduction of systemic Dkk1 levels.…”
Section: Journal Of Bone and Mineral Researchmentioning
confidence: 85%
“…Why the decrease in osteoclast numbers in Dkk1 conditional knockout mice failed to decrease bone resorption as displayed by serum CTX levels remains to be further clarified. Likely, a transient effect on osteoclasts may be envisaged, similar to the suppression of osteoclast activity by sclerostin, which likewise remains to be conclusively addressed …”
Section: Discussionmentioning
confidence: 99%