2019
DOI: 10.1002/jcp.28684
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Sclerostin inhibits odontogenic differentiation of human pulp‐derived odontoblast‐like cells under mechanical stress

Abstract: Sclerotic dentin is a natural self-protective barrier beneath non-carious cervical lesions (NCCLs), which are mainly induced by mechanical stress. Sclerostin is a mechanosensory protein and serves as an inhibitor of dentinogenesis. However, its function on mechanotransduction in dentine-pulp complex has not been elucidated yet. In this study, decreased sclerostin expression was detected in odontoblasts beneath NCCL-affected sclerotic dentin. Then human pulp-derived odontoblast-like cells (hOBs) were subjected … Show more

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Cited by 16 publications
(17 citation statements)
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“…Sclerostin produced by osteocytes suppresses osteogenesis (Moester et al, 2010), but its inhibition induces bone formation (Zhang et al, 2020). Sclerostin also inhibits odontoblastic features of HDPCs (Liao et al, 2019), whereas deficiency of sclerostin facilitates reparative dentin formation in vivo (Figure 2B; Collignon et al, 2017). Notably, Ou et al (2018) reported that HDPCs from older individuals have increased sclerostin production, while overexpression of sclerostin in young HDPCs induces senescent features ( Figure 2B).…”
Section: Senescence Of Dental Pulp Cellsmentioning
confidence: 99%
“…Sclerostin produced by osteocytes suppresses osteogenesis (Moester et al, 2010), but its inhibition induces bone formation (Zhang et al, 2020). Sclerostin also inhibits odontoblastic features of HDPCs (Liao et al, 2019), whereas deficiency of sclerostin facilitates reparative dentin formation in vivo (Figure 2B; Collignon et al, 2017). Notably, Ou et al (2018) reported that HDPCs from older individuals have increased sclerostin production, while overexpression of sclerostin in young HDPCs induces senescent features ( Figure 2B).…”
Section: Senescence Of Dental Pulp Cellsmentioning
confidence: 99%
“…As limitations of the study, we can mention the impossibility of comparing the results obtained and their application in clinical experimental studies. However, it is important to note that the data from this study is valid for an initial study of this subject and should be considered so that new approaches can be taken to assess the adhesion strength in NCCLs, which are often found in clinical practice (Liao et al, 2019;Sun et al, 2015).…”
Section: Discussionmentioning
confidence: 99%
“…Clinically there has been an increase in the appearance of non‐carious cervical lesions (NCCLs) resulting from multifactorial problems, such as abrasion, erosion, and corrosion (Liao et al, ; Sun et al, ). The treatment consists mainly of the use of adhesive systems to improve aesthetics and decrease dentin sensitivity (Rocha et al, ).…”
Section: Introductionmentioning
confidence: 99%
“…By contrast, another study suggested that mechanical stress may induce differentiation of human pulp‐derived odontoblast‐like cells by inhibiting the STAT3 pathway (Liao et al . 2019). The relationship between KLF6 and STAT3 during odontoblast differentiation remains elusive, but this may be one pathway involved in KLF6‐dependent effects.…”
Section: Discussionmentioning
confidence: 99%