Sclerostin injection enhances orthodontic tooth movement in rats

Lu, Wenxin; Zhang, Xuan; Firth, Fiona; Li, Mei; Yi, Jianru; Gong, Changyang; Li, Hanshi; Zheng, Wei; Liu, Yu

doi:10.1016/j.archoralbio.2018.12.011

Cited by 20 publications

(34 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the classic pressure-tension hypothesis, orthodontic force-induced tooth movement is considered an alveolar bone remodelling process, involving bone resorption on the pressure side and deposition on the tension side. 8,9,26 However, the biological reaction of bone under a mechanical stimulus appeared not to be localised. The conventionally studied alveolar bone adjacent to the roots 6,27 during OTM only occupies a small proportion of the alveolar bone, while biological responses of the entire alveolar bone under local orthodontic force are seldom reported.…”

Section: Discussionmentioning

confidence: 99%

Local orthodontic force initiates widespread remodelling of the maxillary alveolar bone

Gong

Huang

Yang

et al. 2020

Australasian Orthodontic Journal

View full text Add to dashboard Cite

Objectives To clarify the effects of a local orthodontic force on alveolar bone by analysing bone remodelling in different regions of the maxilla during orthodontic tooth movement (OTM). Methods An OTM model was established in rats. Histological changes in the maxilla were analysed using TRAP staining, IHC staining for CTSK and haematoxylin and eosin (H and E) staining. The root bifurcation region of the alveolar bone of the first (M1), second (M2) and third (M3) molars were selected as the regions of interest (ROIs), which were further divided into a cervical and an apical level. Sequential fluorochrome labelling was performed to analyse bone deposition rates. Results The maxillary left first molars were moved mesially. TRAP staining and IHC staining for CTSK showed orthodontic force increased osteoclast numbers in all six ROIs at both the cervical and apical levels. H and E staining indicated elevated osteoblast numbers in the OTM group in all induced regions. Sequential fluorochrome labelling exhibited increased bone deposition rates around M1, M2 and M3 in the OTM group. Conclusions An orthodontic force applied to the first molar could initiate widespread remodelling of the maxillary alveolar bone, which was not restricted to the tension and pressure sites. This may revise the orthodontic biomechanical theory and provide new insights for clinical work.

show abstract

Section: Discussionmentioning

confidence: 99%

Local orthodontic force initiates widespread remodelling of the maxillary alveolar bone

Gong

Huang

Yang

et al. 2020

Australasian Orthodontic Journal

View full text Add to dashboard Cite

show abstract

“…Eight articles in experimental animal models were included; four studies were conducted on rats [20][21][22][23], two used rabbits [24,25], one study was conducted on mice [26] and one study on guinea pigs [27], as shown in Table 1. A quality assessment was performed according to the ARRIVE guidelines [18].…”

Section: Selection Of Studiesmentioning

confidence: 99%

“…All studies used a hydrogel of different polymer-gelatin-based composition [20,[24][25][26][27], chitosan hydrogel [20], polyethylene glycol-polycaprolactone-polyethylene glycol [21], hydroxyethyl cellulose [22], methylcellulose [23] for delivery of active substances: carbonated hydroxyapatite [24,25], curcumin [20], sclerostin [21], a formulation of RANKL [22], risedronate bisphosphonate [27], epigallocatechin [26] and parathyroid hormone [23], to accelerate orthodontic tooth movement or inhibit the post treatment relapse. Tooth movement was measured with a digital vernier or in the tomographic software depending on each article.…”

Section: General Characteristics Of the Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Use of Hydrogels to Regulate Orthodontic Tooth Movement in Animal Models: A Systematic Review

et al. 2022

View full text Add to dashboard Cite

The objective of this article is to conduct a systematic review of the literature to contrast the existing evidence regarding the use of hydrogels during and after experimental orthodontic treatment in animals. An extensive search was performed through the electronic databases, Medline, Web of Science and Scopus, from December 2020 to April 2021 for in vivo animal studies. A total of 282 studies were reviewed. Eight studies were included for final revision; four studies were conducted in rats, two in rabbits, one study in mice and one study in guinea pigs. The quality assessment of the eight included studies was performed according to the ARRIVE guidelines and the risk of bias was assessed using the Center for Systematic Review of Laboratory Animal Experimentation tool; in four of the eight articles evaluated, a high risk-of-bias rating was obtained in 40% of the criteria evaluated. In the studies reviewed, the hydrogel acted as a carrier, and inhibition (post-treatment retention) or acceleration of orthodontic tooth movement was assessed according to the active substance used in each of the articles. The uses of hydrogels for transporting active substances to regulate the rate of orthodontic tooth movement remains debatable. Future studies are suggested to evaluate the feasibility of hydrogel as a transport method in humans.

show abstract

“…While surgical interventions have been studied extensively, nonsurgical interventions is easier to be accepted in clinical application [91]. In a recent study, sclerostin administration on the compression side promoted osteoclastogenesis without affecting the osteoblastic activity on the tension side in orthodontic tooth movement on rat [92], indicating sclerostin is promising to be a modulator for non-surgical acceleration of orthodontic tooth movement.…”

Section: Sclerostin In Orthodontic Tooth Movementmentioning

confidence: 99%

"Sclerostin in Oral Tissues: Distribution, Biological Functions and Potential Therapeutic Role"

Han

2020

OAJBS

View full text Add to dashboard Cite

Sclerostin is a well-known osteogenic negative regulator whose biological functions have been widely studied in bone homeostasis. Targeting sclerostin via monoclonal antibodies was shown to be a powerful strategy for bone-related diseases. Traditionally, sclerostin was known as an osteocyte-specific glycoprotein. However, in recent studies, it has been shown that in addition to osteocytes, there are other cell types in oral tissues that can produce sclerostin. Sclerostin regulates the formation of dental and periodontal structures and is also involved in various physiological and pathological events in oral tissues. Thus, sclerostin modulation has been determined as a possible treatment strategy for periodontium-related diseases. To develop the therapeutic potential of sclerostin and its antibodies in the field of dentistry, researchers must clearly understand the functions of sclerostin in oral tissues. In this review, we highlight the existing awareness of sclerostin's functions in oral tissues; the roles it plays in dental and periodontal diseases and treatments; and the therapeutic potential of sclerostin and its antibodies for oral applications.

show abstract

Sclerostin injection enhances orthodontic tooth movement in rats

Cited by 20 publications

References 29 publications

Local orthodontic force initiates widespread remodelling of the maxillary alveolar bone

Local orthodontic force initiates widespread remodelling of the maxillary alveolar bone

Use of Hydrogels to Regulate Orthodontic Tooth Movement in Animal Models: A Systematic Review

"Sclerostin in Oral Tissues: Distribution, Biological Functions and Potential Therapeutic Role"

Contact Info

Product

Resources

About