Sclerotherapy for lymphatic malformations in children: a scoping review

Churchill, Paige; Otal, Damanjot; Pemberton, Julia; Ali, Aiman; Flageole, Hélène; Walton, J. Mark

doi:10.1016/j.jpedsurg.2011.02.027

Cited by 75 publications

(77 citation statements)

References 45 publications

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“…84 Since the first studies carried out by Ogita et al, 85 OK-432 (Picibanil; Chugai Pharmaceutical Co. Ltd, Tokyo, Japan) has proven to be the most suitable drug. The numerous works published, 85,86 also analysed OK-432 in comparison with other sclerosing agents, confirm that OK-432 is the less invasive drug, with a higher average response, and characterized by an effectiveness ranging from 85% to 98%. Experience with sclerosing therapy of the microcystic lymphangioma using OK-432 has led to disappointing results, with an efficacy of 33%.…”

Section: Osteoid Osteomamentioning

confidence: 82%

Paediatric musculoskeletal interventional radiology

Natali¹,

Paolantonio²,

Fruhwirth³

et al. 2016

BJR

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Interventional radiology technique is now well established and widely used in the adult population. Through minimally invasive procedures, it increasingly replaces surgical interventions that involve higher percentages of invasiveness and, consequently, of morbidity and mortality. For these advantageous reasons, interventional radiology in recent years has spread to the paediatric age as well. The aim of this study was to review the literature on the development, use and perspectives of these procedures in the paediatric musculoskeletal field. Several topics are covered: osteomuscle neoplastic malignant and benign pathologies treated with invasive diagnostic and/or therapeutic procedures such as radiofrequency ablation in the osteoid osteoma; invasive and non-invasive procedures in vascular malformations; treatment of aneurysmal bone cysts; and role of interventional radiology in paediatric inflammatory and rheumatic inflammations. The positive results that have been generated with interventional radiology procedures in the paediatric field highly encourage both the development of new ad hoc materials, obviously adapted to young patients, as well as the improvement of such techniques, in consideration of the fact that childrens' pathologies do not always correspond to those of adults. In conclusion, as these interventional procedures have proven to be less invasive, with lower morbidity and mortality rates as well, they are becoming a viable and valid alternative to surgery in the paediatric population. MUSCULOSKELETAL MALIGNANT TUMOURSOsteosarcoma, Ewing sarcoma and rhabdomyosarcoma are the most common musculoskeletal tumours of childhood and adolescence.

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Section: Osteoid Osteomamentioning

confidence: 82%

Paediatric musculoskeletal interventional radiology

Natali¹,

Paolantonio²,

Fruhwirth³

et al. 2016

BJR

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“…One of the most safe and effective ways of cystic LMs treatment in children is the OK-432 sclerotherapy [5,16]. The OK-432 (Chugai Pharmaceuticals, Tokyo, Japan) is a lyophilized powder of Streptococcus pyogenes (group A, type 3, Su strain) incubated with benzylpenicillin.…”

Section: Discussionmentioning

confidence: 99%

“…These lesions are present at birth and have a progressive clinical course. The incidence of LMs is evidenced in about 1 to 6000 to 1 to 16,000 live births, with a frequency of hospitalization -3 cases per 100,000 [4,5]. LMs near the principal lymphatic chains in the neck region are formed when a primordial lymph sac loses or fails to re-establish communication with the central veins (jugular and subclavian) from which it arises [1].…”

Section: Introductionmentioning

confidence: 99%

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Choice of Treatment Options for Cystic Lymphstic Malformations in the Head and Neck Region: Treatment Experience of 81 Children

Benzar

2017

IJMMR

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“…La chirurgie est donc souvent privilégiée, nécessitant souvent d'établir un compromis entre des résultats esthétiques et fonctionnels acceptables et des délabrements importants. La radiofréquence consistant à créer des lésions thermiques en profondeur dans le but de diminuer la taille des ML est égale-ment une option thérapeutique envisageable [18,28,29]. Enfin, l'interféron alpha et 2b [29,30] et le cyclophosphamide [16] ont été employés dans certaines malformations lymphatiques étendues, symptomatiques et inopérables, traitements qui semblent stabiliser les lésions mais dont la tolérance est mauvaise avec un recul actuellement insuffisant pour en connaître les effets secondaires.…”

Section: Fig 2 Patient N° 1 Axial Slices In T1 Without Gadolinium unclassified

Les malformations lymphatiques de la cavité orale, cas cliniques et revue de littérature

Rochefort

Lescaille

Hervé

et al. 2017

Med Buccale Chir Buccale

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Résumé -Introduction : Les malformations lymphatiques (ML) sont congénitales et non régressives. Elles résul-tent d'une anomalie de la morphogenèse embryologique vasculaire et sont détectées dans 80 % des cas avant l'âge de 2 ans, exceptionnellement à l'âge adulte. Asymptomatiques, elles sont le plus souvent diagnostiquées suite à une gêne fonctionnelle. Bien que d'aspects cliniques très hétérogènes, elles se regroupent en deux formes cliniques à distinguer, macrokystiques et microkystiques, dont les traitements et les pronostics diffèrent. L'aspect clinique de la lésion et la symptomatologie sont essentiels pour l'établissement du diagnostic mais aussi pour la décision thérapeutique. Bien qu'une surveillance clinique régulière soit souvent suffisante, une intervention thérapeutique est parfois nécessaire. Observations cliniques : Quatre cas de ML orales avec des aspects cliniques très hétéro-gènes sont présentés. L'un est situé au niveau de l'espace masticateur et de la fosse infratemporale avec une expression muqueuse à la commissure intermaxillaire, deux au niveau des muqueuses jugales et labiales, le quatrième au niveau de la langue. Discussion : Pour trois d'entre eux, le diagnostic a été réalisé à l'âge adulte et ceuxci ne présentaient aucun antécédent de ML. Deux ont été traités par laser, un par chirurgie, le dernier a bénéficié d'une surveillance clinique régulière. Conclusion : Ces quatre cas cliniques sont particulièrement représentatifs de l'hétérogénéité clinique buccale et thérapeutique de ces malformations.Abstract -Oral lymphatic malformations, case reports and review of the literature. Introduction: Lymphatic malformations (LMs) are congenital and non-regressive lesions. These lesions are due to embryological vascular morphogenesis abnormality. Most of them (80 %) are detected before 2 years old, and thus they are rarely found in adults. They are asymptomatic, so their diagnosis is often linked to functional discomfort. There are two clinical aspects with different prognoses: macrocystic and microcystic. Clinical aspects and symptomatology are essential for positive diagnosis and therapeutic decisions. For most cases, simple clinical observation is advised. However, in other cases associated with aesthetic or functional discomfort, therapeutic intervention is recommended, most of the time with sclerotherapy or surgery. Clinical observation: We present four patients with different types of lymphatic malformation: one is on the intermaxillary commissure, the second is on the cheek mucosa, the third is on the lip and the fourth is on the tongue. Discussion: For three of them, the diagnosis was established in adulthood with no past history of LMs. Two patients were treated by laser, one with surgery and for the last one, clinical follow-up was established. Conclusion: These four case reports are representative oral illustrations of the clinical aspects and therapeutic heterogeneity of this pathology.

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Sclerotherapy for lymphatic malformations in children: a scoping review

Cited by 75 publications

References 45 publications

Paediatric musculoskeletal interventional radiology

Paediatric musculoskeletal interventional radiology

Choice of Treatment Options for Cystic Lymphstic Malformations in the Head and Neck Region: Treatment Experience of 81 Children

Les malformations lymphatiques de la cavité orale, cas cliniques et revue de littérature

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