Scolopendra bites: a report of two cases and review of the literature

Veraldi, Stefano; Çuka, Ermira; Gaiani, Francesca

doi:10.1111/ijd.12434

Cited by 24 publications

(19 citation statements)

References 19 publications

(108 reference statements)

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“…Centipede sting reactions are usually self-limiting, transient reactions that are managed with supportive care and resolve without sequelae [2][3][4]. The most common symptom is pain, accompanied by erythema and edema [1]. Intense pain is reported, particularly with the Scolopendra genus [4].…”

Section: Patientmentioning

confidence: 99%

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Skin reactions caused by centipedes: Long‐lasting necrosis and late‐onset local reaction

Özkaya

Yılmaz

2020

J Deutsche Derma Gesell

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Centipedes are nocturnal, fast-moving, multisegmented arthropods [1, 2]. To date, approximately 20 genera and 3000 species have been identified; Scolopendra is the most wellknown and largest centipede with a length ranging from 8 to 20 cm [1, 3]. Centipedes favor tropical and warm temperate regions [3]. Accidental encounters usually take place during summer, at night-time, and in indoor settings [4]. Centipedes inject venom through their sharp, stinging structures called forcipules, which are derived from their first pair of legs [2]. It is therefore reasonable to refer to a "centipede sting" or "centipede envenomation" rather than a "centipede bite" [2, 3]. Centipede sting reactions are rarely reported in the dermatological literature [1], probably because they are usually mild. Here we report on two patients who presented with peculiar dermatologic reactions following centipede envenomation.

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Section: Patientmentioning

confidence: 99%

“…Intense pain is reported, particularly with the Scolopendra genus [4]. Hemorrhagic vesicles, pustules, local numbness and paresthesia at the site of the sting have also been reported [1]. These reactions usually appear within minutes or sometimes several days following the envenomation [1].…”

Section: Patientmentioning

confidence: 99%

Skin reactions caused by centipedes: Long‐lasting necrosis and late‐onset local reaction

Özkaya

Yılmaz

2020

J Deutsche Derma Gesell

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“…Fortunately, reports of human deaths due to centipede envenomation are rare and mostly attributable to secondary infections [198]. However, bites by centipedes, particularly Scolopendra spp., causes intense pain with local erythema, edema, indurations, and necrosis, and in some cases headache, malaise, and dizziness [197,199], but there are also reports of more severe (hemodynamic) symptoms [200] and anaphylaxis [201].…”

Section: Bioactive Compounds From Chilopodamentioning

confidence: 99%

Exploring the global animal biodiversity in the search for new drugs – Spiders, scorpions, horseshoe crabs, sea spiders, centipedes, and millipedes

Mans¹

2017

J Transl Sci

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Drug discovery and development programs have historically mainly focused on plants with medicinal properties and the extensive knowledge of traditional healers about these plants. More recently, the vast array of marine invertebrates and insects throughout the world have been recognized as additional sources for identifying unusual lead compounds to obtain structurally novel and mechanistically unique therapeutics. The results from these efforts are encouraging and have yielded a number of clinically useful drugs. However, many arthropods other than insects -such as spiders, scorpions, horseshoe crabs, sea spiders, centipedes, and millipedes -also produce hundreds of bioactive substances in their venom that may become useful in the clinic. Many of these chemicals are defensive and predatory weapons of these creatures and have been refined during millions of years of evolution to rapidly and with high specificity and high affinity shut down critical molecular targets in prey and predators. Exploration of these compounds may lead to the development of, among others, novel drugs for treating diseases caused by abnormalities in humans in the same (evolutionary conserved) molecular targets such as erectyle dysfunction, botulism, and autoimmune disorders, as well as the identification of novel antineoplastic, antimicrobial, and antiparasitic compounds. This paper addresses the importance of bioactive compounds from spiders, scorpions, horseshoe crabs, sea spiders, centipedes, and millipedes to these advances.

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“…There are approximately 3300 species of centipede within five extant orders including Scutigeromorpha, Lithobiomorpha, Craterostigmomorpha, Scolopendromorpha and Geophilomorpha, which are distributed worldwide on all continents except Antarctica ( Figure 1) [1,3,4]. The species in genus Scolopendra within Scolopendromorpha represents the best known centipedes because they are frequently involved in human accidents [5,6]. Centipedes prey mainly upon other arthropods by subduing them with venom injected via the forcipules, which stem from the first pair of legs [1].…”

Section: Introductionmentioning

confidence: 99%

“…Centipede bites produce extremely sharp pain in humans [1,5]. Human victims bitten by centipedes usually experience intense burning pain, redness, swelling, chills, fever and weakness [8,14].…”

Section: Introductionmentioning

confidence: 99%

Centipede Venom Peptides Acting on Ion Channels

Chu

Qiu

2020

Toxins

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Centipedes are among the oldest venomous arthropods that use their venom to subdue the prey. The major components of centipede venom are a variety of low-molecular-weight peptide toxins that have evolved to target voltage-gated ion channels to interfere with the central system of prey and produce pain or paralysis for efficient hunting. Peptide toxins usually contain several intramolecular disulfide bonds, which confer chemical, thermal and biological stability. In addition, centipede peptides generally have novel structures and high potency and specificity and therefore hold great promise both as diagnostic tools and in the treatment of human disease. Here, we review the centipede peptide toxins with reported effects on ion channels, including Nav, Kv, Cav and the nonselective cation channel polymodal transient receptor potential vanilloid 1 (TRPV1).

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Scolopendra bites: a report of two cases and review of the literature

Abstract: Western dermatologists should be aware of the possibility of severe skin reactions caused by centipede bites.

Cited by 24 publications

References 19 publications

Skin reactions caused by centipedes: Long‐lasting necrosis and late‐onset local reaction

Skin reactions caused by centipedes: Long‐lasting necrosis and late‐onset local reaction

Exploring the global animal biodiversity in the search for new drugs – Spiders, scorpions, horseshoe crabs, sea spiders, centipedes, and millipedes

Centipede Venom Peptides Acting on Ion Channels

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