Scoparone attenuates angiotensin II-induced extracellular matrix remodeling in cardiac fibroblasts

Bao, Futing; Su, Yi; Ma, Xin; Mu, Chunyan; Yu, Feihong

doi:10.1016/j.jphs.2018.05.006

Cited by 18 publications

(10 citation statements)

References 31 publications

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“…15 SCO could inhibit Ang II-induced extracellular matrix remodelling in cardiac fibroblasts in vitro at least partly by inhibiting TGF-β1/Smad signalling. 16 SCO also showed a protective effect against ischaemia-reperfusion-induced myocardial injury by counteracting oxidative stress. 17 However, the effect of SCO on Ang II-induced myocardial hypertrophy is still unknown.…”

Section: Introductionmentioning

confidence: 89%

“…In the cardiovascular system, SCO was reported to be a potent hypotensive drug, with a probable mechanism of vascular dilatory action based on calcium mobilization regulation 15 . SCO could inhibit Ang II‐induced extracellular matrix remodelling in cardiac fibroblasts in vitro at least partly by inhibiting TGF‐β1/Smad signalling 16 . SCO also showed a protective effect against ischaemia‑reperfusion‑induced myocardial injury by counteracting oxidative stress 17 .…”

Section: Introductionmentioning

confidence: 99%

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Scoparone alleviates Ang II‐induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress

Lyu

Chen

Wang

et al. 2021

J Cellular Molecular Medi

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Long‐term poorly controlled myocardial hypertrophy often leads to heart failure and sudden death. Activation of ras‐related C3 botulinum toxin substrate 1 (RAC1) by angiotensin II (Ang II) plays a pivotal role in myocardial hypertrophy. Previous studies have demonstrated that scoparone (SCO) has beneficial effects on hypertension and extracellular matrix remodelling. However, the function of SCO on Ang II‐mediated myocardial hypertrophy remains unknown. In our study, a mouse model of myocardial hypertrophy was established by Ang II infusion (2 mg/kg/day) for 4 weeks, and SCO (60 mg/kg bodyweight) was administered by gavage daily. In vitro experiments were also performed. Our results showed that SCO could alleviate Ang II infusion‐induced cardiac hypertrophy and fibrosis in mice. In vitro, SCO treatment blocks Ang II‐induced cardiomyocyte hypertrophy, cardiac fibroblast collagen synthesis and differentiation to myofibroblasts. Meanwhile, we found that SCO treatment blocked Ang II‐induced oxidative stress in cardiomyocytes and cardiac fibroblasts by inhibiting RAC1‐GTP and total RAC1 in vivo and in vitro. Furthermore, reactive oxygen species (ROS) burst by overexpression of RAC1 completely abolished SCO‐mediated protection in cardiomyocytes and cardiac fibroblasts in vitro. In conclusion, SCO, an antioxidant, may attenuate Ang II‐induced myocardial hypertrophy by suppressing of RAC1 mediated oxidative stress.

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Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Scoparone alleviates Ang II‐induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress

Lyu

Chen

Wang

et al. 2021

J Cellular Molecular Medi

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“…The treatment with 22 increased cell viability, superoxide dismutase levels, and B cell lymphoma 2 protein expression and decreased lactate dehydrogenase release, malondialdehyde production, creatine kinase levels, reactive oxygen species concentration, cell apoptotic rate, myocardial infarct area, and Bcl-2-associated X protein, and caspase-3 and cytochrome c protein expression. Effect of this compound against cardiac fibrosis was reported by Fu et al (2018), where the possible remedial effect of 22 on angiotensin II-induced extracellular matrix remodeling and its possible mechanism in cardiac fibroblasts was established.…”

Section: Cardioprotectionmentioning

confidence: 99%

Dietary Coumarins

Sarker¹,

Nahar²

2019

Handbook of Dietary Phytochemicals

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Dietary phytochemicals are bioactive components of plant-based foods (phytofoods), e.g., fruits, vegetables, grains, and tea. Their regular and adequate intake may offer protection from major chronic diseases, including cardiovascular diseases, cancer, and neurodegenerative diseases. Phyto-foods like apples, blueberries, broccoli, cherries, soybeans, and walnuts contain bioactive phytochemicals of various chemical classes, in addition to usual micronutrients and fibers. One of such major groups of phytochemicals found in plant-based food items are naturally occurring coumarins, which belong to the chemical class of 1-benzopyran derivatives. Plants from the families Apiaceae, Asteraceae, and Rutaceae are three major sources of naturally occurring coumarins. Some commonly consumed coumarincontaining phyto-foods include carrots, celery, parsnip, strawberries, citrus fruits, apricots, and cherries, as well as spices like cinnamon and fennels. This chapter presents a coverage primarily on most common coumarins that occur in food plants and their contributions to human health and wellbeing.

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“…Choleretic effect of scoparone is indirectly potenti P4501A2 via the bile salt export pump promoter [55]. Scoparone is co hepatoprotective candidate for hepatitis therapy based on publi Additionally, scoparone 60 mg/kg daily could alleviate angiotensin cardiac hypertrophy and fibrosis in mice with maintaining cardiac ou pressure, and left ventricular workload [57,58].…”

Section: Pharmacokinetics Of Bioactive Compounds Found In Artemisia Capillarismentioning

confidence: 99%

“…Scoparone is considered a potential hepatoprotective candidate for hepatitis therapy based on published evidence [56]. Additionally, scoparone 60 mg/kg daily could alleviate angiotensin II infusion-induced cardiac hypertrophy and fibrosis in mice with maintaining cardiac output, left ventricular pressure, and left ventricular workload [57,58].…”

Section: Scoparonementioning

confidence: 99%

The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris

et al. 2021

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Artemisia capillaris Thunb. (A. capillaris, Yin-Chen in Chinese) is a traditional medicinal herb with a wide spectrum of pharmacological properties ranging from effects against liver dysfunction to treatments of severe cirrhosis and cancer. We used relevant keywords to search electronic databases, including PubMed, Medline, and Google Scholar, for scientific contributions related to this medicinal herb and the pharmacokinetics of its components. The pharmaceutical effects of A. capillaris contribute to the treatment not only of viral hepatitis, cirrhosis, and hepatocellular hepatoma, but also metabolic syndrome, psoriasis, and enterovirus in the clinic. The bioactive compounds, including scoparone, capillarisin, scopoletin, and chlorogenic acid, exhibit antioxidant, anti-inflammatory, antisteatotic, antiviral, and antitumor properties, reflecting the pharmacological effects of A. capillaris. The pharmacokinetics of the main bioactive compounds in A. capillaris can achieve a maximum concentration within 1 hour, but only chlorogenic acid has a relatively long half-life. Regarding the use of the A. capillaris herb by health professionals to treat various diseases, the dosing schedule of this herb should be carefully considered to maximize therapeutic outcomes while lessening possible side effects.

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Scoparone attenuates angiotensin II-induced extracellular matrix remodeling in cardiac fibroblasts

Cited by 18 publications

References 31 publications

Scoparone alleviates Ang II‐induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress

Scoparone alleviates Ang II‐induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress

Dietary Coumarins

The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris

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