Scope and limitations of in vivo brain dialysis: A comparison of its application to various neurotransmitter systems

Westerink, Ben H.C.; Damsma, G.; Rollema, Hans; Vries, J. B. De; Horn, Alan S.

doi:10.1016/0024-3205(87)90695-3

Cited by 424 publications

(129 citation statements)

References 34 publications

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“…In mammalian VTA neurons, phasic firing-induced DA release is associated with rapid DA reuptake through the DAT that is difficult to detect by microdialysis (possible with undirected singing), whereas tonic firing-induced DA release is associated with slow DA reuptake through the DAT that is easier to detect by microdialysis (possible with directed singing) (Floresco et al, 2003;Venton et al, 2003). It is likely that more temporally refined measurement of extracellular DA, such as in voltammetry Gale and Perkel, 2005;Wightman, 2006), will lead to a more precise determination of DA kinetics in each social context, because microdialysis can only detect accumulation of DA that has escaped reuptake and diffused some distance from release sites (Westerink et al, 1987). We also do not yet know whether the higher DA levels seen during directed singing occurs only in Area X or in Area X and the surrounding striatum, because we did not measure DA outside of Area X.…”

Section: Discussionmentioning

confidence: 99%

Social Context-Dependent Singing-Regulated Dopamine

Sasaki¹,

Sotnikova²,

Gainetdinov³

et al. 2006

J. Neurosci.

174

202

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Like the mammalian striatum, the songbird striatum receives dense dopaminergic input from the midbrain ventral tegmental areasubstantia nigra pars compacta complex. The songbird striatum also contains a unique vocal nucleus, Area X, which has been implicated in song learning and social context-dependent song production. Area X shows increased neural firing and activity-dependent gene expression when birds sing, and the level of activation is higher and more variable during undirected singing relative to directed singing to other birds. Here we show in the first report of in vivo microdialysis in awake, behaving songbirds that singing is associated with increased dopamine levels in Area X. Dopamine levels are significantly higher with directed relative to undirected singing. This social context-dependent difference in dopamine levels requires the dopamine transporter, because local in vivo blockade of the transporter caused dopamine levels for undirected singing to increase to levels similar to that for directed singing, eliminating the social contextdependent difference. The increase in dopamine is presumably depolarization and vesicular release dependent, because adding of high K ϩ increased and removal of Ca 2ϩ increased and decreased extracellular DA levels. Our findings implicate DA and molecules that control DA kinetics in singing behavior and social context-dependent brain function.

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Section: Discussionmentioning

confidence: 99%

Social Context-Dependent Singing-Regulated Dopamine

Sasaki¹,

Sotnikova²,

Gainetdinov³

et al. 2006

J. Neurosci.

174

202

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“…Microdialysis in the corpus striatum was performed with an Ishaped cannula (Santiago & Westerink, 1990 fully automated on-line system as has been described preBritish Journal of Pharmacology (1995) 116, 1545 -1550 viously (Westerink et al, 1987a output was not affected by PBG perfusion at any concentration studied (data not shown).…”

Section: Surgery and Brain Dialysismentioning

confidence: 99%

5‐HT₃ receptor agonist induced carrier‐mediated release of dopamine in rat striatum in vivo

Santiago

Machado

Cano

1995

British J Pharmacology

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1 In vivo microdialysis was used to study the effect of phenylbiguanide (PBG), a 5-hydroxytryptamine3 receptor agonist, on the extracellular output of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the corpus striatum.2 PBG produced a dose-related (10-500 gM) increase in the release of dopamine (280-2000%).DOPAC and HVA output decreased with the perfusion of PBG. This decrease was similar with 50-500 Mm PBG. 5-HIAA output was not affected by any PBG concentration used.3 When nomifensine (5 gM) was included in the Ringer solution, the effect of PBG on the release of dopamine was ameliorated or inhibited. However, the effect of PBG (50-500 gM) on the extracellular output of DOPAC and HVA was similar in the absence and in the presence of nomifensine (5 gM). 6 These results suggest that the effect of PBG on the release of dopamine is mainly carrier-mediated.

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“…Microdialysis has been proposed as a method for monitoring in vivo neurotransmitter release, in brain and peripheral tissue (Ungerstedt et al 1982;see Ungerstedt 1984see Ungerstedt , 1991, and it has been widely used for monitoring the effects of amphetamines (Zetterström et al 1983(Zetterström et al , 1986Westerink et al 1987;Butcher et al 1988;Hurd and Ungerstedt 1989a,b), including those of Meth (O'Dell et al 1991;Nash and Yamamoto 1992;Holson et al 1996;Sabol et al 2001).…”

mentioning

confidence: 99%

Effect of single and repeated methamphetamine treatment on neurotransmitter release in substantia nigra and neostriatum of the rat

Bustamante

You²,

Castel

et al. 2002

Journal of Neurochemistry

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The main purpose of this study was to characterize the initial neurotransmission cascade elicited by methamphetamine, analysing simultaneously with in vivo microdialysis monoamine, amino acid and neuropeptide release in substantia nigra and neostriatum of the rat. The main effect of a single systemic dose of methamphetamine (15 mg/kg, subcutaneously) was an increase in dopamine levels, both in substantia nigra ( 10-fold) and neostriatum ( 40-fold), accompanied by a significant, but lesser, increase in dynorphin B ( two-fold, in both regions), and a decrease in monoamine metabolites. A similar effect was also observed after local administration of methamphetamine (100 lM) via the microdialysis probes, but restricted to the treated region. In other experiments, rats were repeatedly treated with methamphetamine or saline, with the last dose administered 12 h before microdialysis. Dopamine K + -stimulated release was decreased following repeated methamphetamine administration compared with that following saline, both in the substantia nigra (by 65%) and neostriatum (by 20%). In contrast, the effect of K + -depolarization on glutamate, aspartate and GABA levels was increased following repeated administration of methamphetamine. In conclusion, apart from an impairment of monoamine neurotransmission, repeated methamphetamine produces changes in amino acid homeostasis, probably leading to NMDA-receptor overstimulation.

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Scope and limitations of in vivo brain dialysis: A comparison of its application to various neurotransmitter systems

Cited by 424 publications

References 34 publications

Social Context-Dependent Singing-Regulated Dopamine

Social Context-Dependent Singing-Regulated Dopamine

5‐HT₃ receptor agonist induced carrier‐mediated release of dopamine in rat striatum in vivo

Effect of single and repeated methamphetamine treatment on neurotransmitter release in substantia nigra and neostriatum of the rat

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Scope and limitations of in vivo brain dialysis: A comparison of its application to various neurotransmitter systems

Cited by 424 publications

References 34 publications

Social Context-Dependent Singing-Regulated Dopamine

Social Context-Dependent Singing-Regulated Dopamine

5‐HT3 receptor agonist induced carrier‐mediated release of dopamine in rat striatum in vivo

Effect of single and repeated methamphetamine treatment on neurotransmitter release in substantia nigra and neostriatum of the rat

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5‐HT₃ receptor agonist induced carrier‐mediated release of dopamine in rat striatum in vivo