Scope of phytotherapeutics in targeting ACE2 mediated Host-Viral Interface of  SARS‐CoV2 that causes COVID-19

Sivaraman, D.; S, Pradeep P.

doi:10.26434/chemrxiv.12089730

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…30 In silico studies show that Spathulenol could bind to angiotensin-converting enzyme 2 (ACE2) receptors by which SARS-CoV-2 gains access into the host cell, which is expected to interfere with host-viral interaction. 38 Eugenia umbelliflora, which is frequently identified as Brazilian cherry, shows anti-inflammatory action by reducing the influx of PMN to the inflamed tissue, as well as reducing the cytokine IL-1β levels. This anti-inflammatory activity was also accompanied by significant anti-hypersensitive effect.…”

Section: Resultsmentioning

confidence: 99%

Phytotherapeutic Approaches and Ethnopharmacological Responses Against COVID-19

Al‐Samydai¹,

Hajleh²,

Akour³

et al. 2021

TJNPR

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The coronavirus disease 2019 (COVID-19) pandemic, the most important public health problem in 2020, poses severe health and socioeconomic impact. Many people turn to herbal therapy to prevent infection with the virus or alleviate the symptoms caused by it. This study evaluates the patterns of phytotherapy-based product utilization in the prevention against SARS-COV-2 and their reported effectiveness. This cross-sectional survey used a convenience sample of 287 adults who had used any form of phytotherapeutics to help fight and/or treat COVID-19 infection. The majority (n = 194, 67.6%) of participants had used plants from the Rutaceae family (like lemon and oranges), followed by those of Amaryllidaceous (namely, Garlic and Onion). Participants said that physicians and pharmacists were the primary sources of information about phytotherapy (n=107, 37.3%), and their decision was driven by their positive attitude towards herbal medicine or plant-based products (n=133, 46.3%). Many participants did not notice any side effects of these remedies (n=270, 94%) and believed they were effective (n = 184, 64%). This study provides an overview of the many phytotherapeutic remedies used in the era of COVID-19 by Jordanian society, which could prompt the conduction of interventional trials to assess the effectiveness and safety of this modality of therapy, either as a stand-alone or adjuvant treatment.

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Section: Resultsmentioning

confidence: 99%

Phytotherapeutic Approaches and Ethnopharmacological Responses Against COVID-19

Al‐Samydai¹,

Hajleh²,

Akour³

et al. 2021

TJNPR

View full text Add to dashboard Cite

show abstract

“…Herbs found to be effective against COVID-19 through in-vivo / in-vitro analysis Plant Family Plant name Antiviral Anti-inflammatory Immunomodulation References In-vitro / in-vivo assays Acanthaceae Andrographis paniculata (Burm.f.) Nees Binding potential with active residues of ACE2 that mediate host viral interface Andrographolide reduces the levels of inflammatory cytokines TNFα, IL-12, IL-1β, IL-6, IL-18 in LPS/ IL-4-activated murine macrophages Andrographolide significantly stimulate the immune response, regulate the production of NK cells and cytokines and stimulate the production of cytotoxic T-lymphocytes Lu et al, 2019 ; Wang et al, 2010 ; Varma et al, 2011 ; Dhanasekaran and Pradeep, 2020 Amaryllidaceae Allium sativum L. Aqueous bulb extracts and essential oils restrained viral protease enzyme by inhibiting amino acid synthesis Allicin inhibit of TNF-induced secretion of IL-1β, CXCL8 and IP10 Crushed garlic extract increase the production of IFNγ and expansion of CD4+ T-cells Mohammadi and Shaghaghi, 2020 ; Lang et al, 2004 ; Arreola et al, 2015 Anacardiaceae Rhus chinensis Mill. Ethanol extract of gall having the inhibitiory activity of SARS-CoV virus into host cell and prevented virus replication Tetra-O-galloyl-β-d-glucose showed to inhibit SARS CoV Aqueous extract inhibits the production of inflammatory cytokine IL-6 in-vivo Aqueous extract inhibits IL-10 expression and act as immunomodulator Yi et al, 2004 ; Djakpo and Yao, 2010 ; Kai et al, 2018; Sun et al, 2018b Asteraceae Echinacea purpurea L. Herb and roots ethanol extract act against some viruses with a membrane through direct virucidal activity Unpurified fresh pressed juice mediated the increased release of various cytokines, including IL-1, IL-10,and TNF-α by macrophages Crude polysaccharides act as immunostimulator Sharma et al, 2009 ; Burger et al, 1997 Brassicaceae Isatis indigotica Fo...…”

Section: Global Perspective Of Herbs and Herbal Formulae From Different Traditional Systems Of Medicine To Inhibit Sars-cov-2 Virusmentioning

confidence: 99%

Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications

et al. 2022

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Background : The worldwide corona virus disease outbreak, generally known as COVID-19 pandemic outbreak resulted in a major health crisis globally. The morbidity and transmission modality of COVID-19 appear more severe and uncontrollable. The respiratory failure and following cardiovascular complications are the main pathophysiology of this deadly disease. Several therapeutic strategies are put forward for the development of safe and effective treatment against SARS-CoV-2 virus from the pharmacological view point but till date there are no specific treatment regimen developed for this viral infection. Purpose : The present review emphasizes the role of herbs and herbs-derived secondary metabolites in inhibiting SARS-CoV-2 virus and also for the management of post-COVID-19 related complications. This approach will foster and ensure the safeguards of using medicinal plant resources to support the healthcare system. Plant-derived phytochemicals have already been reported to prevent the viral infection and to overcome the post-COVID complications like parkinsonism, kidney and heart failure, liver and lungs injury and mental problems. In this review, we explored mechanistic approaches of herbal medicines and their phytocomponenets as antiviral and post-COVID complications by modulating the immunological and inflammatory states. Study design : Studies related to diagnosis and treatment guidelines issued for COVID-19 by different traditional system of medicine were included. The information was gathered from pharmacological or non-pharmacological interventions approaches. The gathered information sorted based on therapeutic application of herbs and their components against SARSCoV-2 and COVID-19 related complications. Methods : A systemic search of published literature was conducted from 2003 to 2021 using different literature database like Google Scholar, PubMed, Science Direct, Scopus and Web of Science to emphasize relevant articles on medicinal plants against SARS-CoV-2 viral infection and Post-COVID related complications. Results : Collected published literature from 2003 onwards yielded with total 625 articles, from more than 18 countries. Among these 625 articles, more than 95 medicinal plants and 25 active phytomolecules belong to 48 plant families. Reports on the therapeutic activity of the medicinal plants belong to the Lamiaceae family (11 reports), which was found to be maximum reported from 4 different countries including India, China, Australia, and Morocco. Other reports on the medicinal plant of Asteraceae (7 reports), Fabaceae (8 reports), Piperaceae (3 reports), Zingiberaceae (3 reports), Ranunculaceae (3 reports), Meliaceae (4 reports) were found, which can be explored for the development of safe and efficacious products targeting COVID-19. Conclusion : K...

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Impact of Covid-19 Pandemic on Consumer behaviour and Preference: Modern or Traditional Medicines?

Wijaya,

Shahimi Mustapha,

Subramaniyan

2023

RJPT

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Backgorund: The COVID-19 pandemic also affects people's behavior (consumers) in Indonesia. To avoid COVID-19, people often consume natural or herbal medicine in addition to chemical medicines. Objective: To analyze the consumers behavior and preference in purchasing modern and traditional medicines during pre and mid pandemic of Covid-19 in East Kalimantan province. Methods: 540 East Kalimantan residents participated in a cross-sectional online survey from December 2021 to February 2022. The survey instrument included demographic information, 4 items on purchasing modern and traditional medicine pre and mid Covid-19. Results: Purchase of traditional medicine prior to the Covid-19 pandemic was 43.7% and mid the covid-19 was 51.5%. Purchase of modern medicine prior to the Covid-19 pandemic was 59.6% and mid the covid-19 was 72.2%. The wilcoxon test for the purchase of traditional and modern medicines before and during covid is <0.001. Conclusion: Consumers in East Kalimantan experienced changes in behavior before the COVID-19 pandemic compared to mid-COVID-19; the highest change was in purchasing modern medicines, and this change in behavior was statistically significant.

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Scope of phytotherapeutics in targeting ACE2 mediated Host-Viral Interface of SARS‐CoV2 that causes COVID-19

Cited by 3 publications

References 10 publications

Phytotherapeutic Approaches and Ethnopharmacological Responses Against COVID-19

Phytotherapeutic Approaches and Ethnopharmacological Responses Against COVID-19

Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications

Impact of Covid-19 Pandemic on Consumer behaviour and Preference: Modern or Traditional Medicines?

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