<p>Severe acute respiratory syndrome coronavirus (SARS-CoV-2) that cause COVID-19 becomes a global threat and spread its pandemicity across the boundaries. Recent demography issued by WHO forecasting the severity of disease prevalence in more than 200 countries resulted in 16,96,588 laboratory confirmed cases excluding 1,05,952 deaths as on 12 April 2020. Countries like USA (4,92,881), Italy (1,52,271), Spain (1,61,852), Germany (1,20,479) are struggling hard to flatten their epidemic curve of COVID-19. Dynamic strategies are of utmost important in order to manage the crucial spread of SARS-CoV-2. Drug of herbal origin may offer reliable therapeutic opportunity in controlling widespread transmission. It was evident from the scientific outcomes that SARS‐CoV-2 gains access in to the host cell through angiotensin-converting enzyme 2 (ACE2) receptors. Hence drugs that reveals potential binding affinity with core amino acid of ACE-2 may expected to interfere the host-viral interaction. In our present investigation 28 lead molecules from well documented medicinal herbs were subjected to molecular docking analysis targeting ACE2 receptor and their potential of impeding host-viral interface were evaluated. Results of computational analysis signifies that out of 28 ligands nearly 11 bioactive lead molecules exhibit potential binding affinity of about 100% with the target amino acid residue (31 Lys and 353 Lys)<br></p>

Introduction: Helicobacter pylori is the known bacteria, causing multiple gastric disorders. Its prevalence in dental plaque noted by multiple researchers. The presence of helicobacter pylori in dental plaque even after systemic eradication done using triple drug therapy noted by few. Purpose of this study was to establish need of oral prophylaxis as an adjunct to systemic eradication of H.pylori. Materials and Methods: Total of 22 H.pylori positive patients divided in two groups irrespective of gender. 14 patient underwent oral prophylaxis and remaining 8 subjects did not, along with triple drug therapy for systemic eradication of H.pylori. Plaque samples from only posteroior teeth collected and PCR was done for detection of H.pylori strains after 6 months. Results: Statistical significant reduction in prevalence of H.pylori noted in patients undergone oral prophylaxis along with anti-H pylori therapy. Conclusion:Oral prophylaxis has to be considered along with anti-H pylori eradication therapy to prevent dental plaque acting as a reservoir causing reinfection.

BACKGROUND Graft-versus-host disease (GVHD) is described as a potentially life-threatening complication caused by allogeneic haematopoietic cell transplantation. It is an exaggerated manifestation of a normal inflammatory mechanism in which donor lymphocytes encounter foreign antigens in an atmosphere that promote inflammation. 90% of the patients show oral features in case of cGVHD. Oral mucosal lesions and salivary gland dysfunction are the main oral features of chronic GVHD. Trismus or reduction of the mouth opening due to the perioral deposition of collagen is also commonly seen. Purpose of this review is to understand pathophysiology of oral presentations of GVHD. MATERIALS AND METHODS Review related to GVHD pathophysiology, oral lesions after haematopoietic cell transplant encompassed literature from 1966 through 2015. Review of Medline/PubMed Journals were done. RESULTS It is difficult to describe the pathophysiology of oral manifestations because there is no well accepted definition. CONCLUSION Larger well-designed clinical studies are needed to understand the pathobiology of oral cGVHD and determine best treatments for this disease.